...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Diabetic nephropathy Glomerulosclerosis Dialysis Translational research Systematic review Deutsche...

... underwent a second renal biopsy at the age of 56 owing to the presence of persistent proteinuria and decline in serum albumin, meeting the diagnostic criteria for nephrotic syndrome. Light microscopy demonstrated glomerulosclerosis and cystic dilatation of the renal tubules. Notably, electron microscopy...

...Kazuhiro Takeuchi; Shokichi Naito; Nagako Kawashima; Naoko Ishigaki; Takashi Sano; Kouju Kamata; Yasuo Takeuchi Background: Focal segmental glomerulosclerosis (FSGS) is considered a subset of the podocytopathies. The molecular pathogenesis of podocytopathy is still unknown. There has not been...

..., in PECs during the progression of focal segmental glomerulosclerosis (FSGS). To clarify the role of CD74 expression and of its interaction with CD44, we generated a new mouse model with enhanced PEC activation through lipopolysaccharide (LPS) application to adriamycin (ADR)-induced nephropathy mice (LPS...

... the versatile roles of its numerous members in diverse cell types, additional functions of the semaphorin-plexin system in renal pathophysiology are likely to emerge in the future. Semaphorin Plexin Diabetic nephropathy Glomerulosclerosis Glomerulonephritis Injury Repair  Systemic lupus...

..., instructions or products referred to in the content or advertisements. Heroin Mesangial cell Glomerulosclerosis Mesangium Antithymocyte serum NEPHRON Original Paper Nephron 1996:74:197-203 Pravin C. Singhaia Calvin Q. Pana SushiI Sagar3 E. Valderramaa RolfAK. StahP a Departments of Medicine...

...Christiane Van den Branden; Roel Verelst; Joseph Vamecq; Katherina Vanden Houte; Dierik Verbeelen In rats with five-sixth nephrectomy (remnant kidney), glomerulosclerosis was significantly reduced by dietary administration of vitamin E (α-tocopherol) during 11 and 16 weeks after reduction...

..., glomerulosclerosis, antioxidant enzyme status and in vivo hydrogen peroxide (H 2 O 2 ) production in rats with chronic renal failure caused by 5/6 nephrectomy (remnant kidney) and compared results to data obtained with propranolol, a β-blocking drug without scavenging characteristics. Carvedilol and propranolol were...

...) in an irreversible glomerulosclerosis rat model induced by two consecutive injections of monoclonal antibody (MoAb) 1-22-3. The rats were intravenously injected with 500 μg of MoAb 1-22-3 either once or twice at an interval of 2 weeks. The rats were sacrificed at 24 h, 1 week, 2 weeks or 16 weeks after the last...

...Chih-Wei Yang; Swei Hsueh; Mai·Szu Wu; Ping-Chin Lai; Jeng-Yi Huang; Ching-Herng Wu; Sau-An Hu; Jung-Fu Chen; Chiu-Ching Huang As transforming growth factor- β1 (TGF- β1) is implicated in the pathogenesis of glomerulosclerosis, the aim of the study was to demonstrate if levels of glomerular TGF- β1...

...Noriaki Ohtsuka; Takanobu Sakemi; Yoshiyuki Tomiyoshi; Fumitaka Morito We have already reported an equally attenuating effect of castration or estrogen administration on the development of focal segmental glomerulosclerosis (FSGS) in the animal models of a short-term experimental period ended at 24...

... To determine the contribution of the ovary to the development of glomerulosclerosis, we investigated the effect of ovariectomy on glomerulosclerosis, using the unilaterally nephrectomized (Nx) female Sprague-Dawley rat. At 6 weeks of age, groups 2 and 3 underwent unilateral right nephrectomy...

... glomerulosclerosis, we studied the effect of the interaction between bacteria such as Escheri-chiα coli and macrophages on MC proliferation and matrix synthesis. We determined the effect of control media (CM), E. coli supernatant (ESP), serum-free macrophage supernatant (MSP), and E. coli -treated macrophage...

... Macrophages seem to play an important role in the development of glomerulosclerosis. In the present study we evaluated the effect of morphine, an active metabolite of heroin, on the migration of monocytes across a filter in a modified Boyden chamber. Morphine-mesangial cell interaction enhanced (p...

...Takanobu Sakemi; Noriaki Ohtsuka; Yoshiyuki Tomiyosi; Fumitaka Morito To clarify a role of sex hormones in greater susceptibility of young rats than adults to the development of focal and segmental glomerulosclerosis (FSGS), we castrated animals at different ages and investigated whether...

.... Enalapril lowered blood pressure by about 30 mm Hg, but was ineffective in reducing urinary protein or albumin excretion rates at any age. Urinary excretion of nitric oxide metabolites was similar in all groups at all time periods. There were significant differences in the percent of glomerulosclerosis...

...V. Kliem; R. Brunkhorst; G. Ehlerding; K. Kühn; K.H. Neumann; K.M. Koch Milan normotensive rats, which spontaneously develop marked proteinuria (PU) and glomerulosclerosis (GS), were either kept on a normal-protein diet, a normal-protein diet with additional low-dose captopril (CAP), which did...

... to in the content or advertisements. Vasopressin Adriamycin-induced nephropathy Proteinuria Glomerulosclerosis NEPHRON Original Paper N ephron 1996;72:667-672 Hirokazu Okada Hiromichi Suzuki Yoshihiko Kauno Takao Saruta Department oflnternal Medicine. School of Medicine. Keio University. Tokyo, Japan...

...Takanobu Sakemi; Noriaki Ohtsuka; Yoshiyuki Shouno; Fumitaka Morito To clarify the pathogenesis of focal and segmental glomerulosclerosis, we investigated the effect of ovariectomy in hypercholesterolemic female Imai rats. At 5 weeks of age, control female (group 1) and control male rats (group 3...

...Takanobu Sakemi; Hajime Toyoshima; Fumitaka Morito Hypercholesterolemic Imai rats, especially males, spontaneously develop proteinuria and glomerulosclerosis. We have shown that castration attenuated the progression of glomerular injury in male Imai rats. The present study was designed...