... thinning of the glomerular basement membrane (GBM) associated with a novel heterozygous variant in the LMX1B gene. A 43-year-old female patient with a previous diagnosis of NPS, referred to our hospital for persistent proteinuria, underwent a renal biopsy, which revealed minor glomerular abnormalities. She...

... heterozygous mutations in the COL4A3/A4 genes that affect the structure of the glomerular basement membrane (GBM) [ 1,2 ]. Homozygous or compound heterozygous mutations in the same genes cause classic autosomal recessive Alport syndrome [ 3,4,5,6,7,8,9 ]. COL4A3/A4/A5 genes encode the 3 chains of collagen...

...Hitoshi Kubosawa; Yoichiro Kondo We reevaluated the distribution of anionic sites in the glomerular basement membrane with ruthenium red, alcian blue, cationic ferritin, polyethyleneimine, and cationic colloidal gold. Without the accentuation by the metal staining with uranyl acetate and lead...

...R. Karasawa; S. Nishi; Y. Suzuki; N. Imai; M. Arakawa A decrease in anionic change and the loss of heparan sulfate proteoglycan have previously been observed in the glomerular basement membrane (GBM) during diabetic glomerulosclerosis. We studied the chronological changes in the anionic character...

... the glomerular basement membrane in the early-onset pre-eclampsia group as compared with the control group (p < 0.02). A strong correlation (r = -0.76) was obtained between the number of anionic sites and the severity of proteinuria. Renal biopsy specimens revealed the coexistence of decreased glomerular...

...Eduardo H. Garin; Leigh West; Kay Blanchard; Koiji Matsushima; Julie Y. Djeu We have previously shown that lymphocytes from idiopathic minimal-lesion nephrotic patients produce a lymphokine (supernatant factor) that increases the 35 sulfate uptake in the glomerular basement membrane (GBM...

...Mitsunori Yagame; Youngki Kim; Dan Zhu; Daisuke Suzuki; Kazahiko Eguchi; Yasuo Nomoto; Hideto Sakai; Thomas Groppoli; Michael W. Steffes; Michael Mauer Thickening of the glomerular basement membrane (GBM) and expansion of the mesangial matrix are hallmarks of human diabetic nephropathy. Renal...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Renal transplantation Alport syndrome Glomerular basement membrane Renal ultrastructure Case Report Nephron 1995;70:106-109 Adalberto Sessaa...

..., instructions or products referred to in the content or advertisements. Mutation COL4A5 gene Type IV collagen Glomerular basement membrane Alport syndrome Alessandro Renieria Mietta Meronih Adalberto Sessab Graziana Battinib Paola Serbellonft Laura Ton i TarellT Marco Serr' Lucia GalIr' Mario De...

... characteristic ultrastructural glomerular basement membrane changes. Our family consisted of 11 members, 5 of which presented with renal dysfunction of varying degrees. Clinically, the affected siblings presented with long-standing hypertension, minimal proteinuria and no hematuria. All known causes...

...Yasushi Yamasaki; Hirofumi Makino; Zensuke Ota We examined the ultrastructure of the bovine glomerular basement membrane (GBM) and tubular basement membrane (TBM) using ultra-high-resolution scanning electron microscopy after conductive staining without metal coating. Purified basement membranes...

... ± 0.1 mg/day) of experiment. In diabetic animals with dilazep treatment, urinary protein excretions (4.1 ± 0.7 at 8 weeks and 13.1 ± 2.9 mg/day at 24 weeks of experiment) were significantly suppressed compared to those in untreated diabetic animals. Significant thickening of glomerular basement membrane...

...Eduardo H. Garin; Nick Corontzes We have previously shown a significant increase in sulfate-35 uptake in rat glomerular basement membrane (GBM) when glomeruli were cultured with peripheral blood mononuclear cells (PBMC) from patients with idiopathic minimal lesion nephrotic syndrome (IMLNS...

...Yoshio Nagake; Hirofumi Makino; Kazue Hironaka; Naoki Kashihara; Zensuke Ota The glomerular basement membrane (GBM) is considered to regulate glomerular permselectivity for proteins by acting as both size barrier and charge barrier. Since heparan sulfate-proteoglycan (HS-PG), which forms the charge...

... results in alteration of the charge-selective properties of glomerular capillaries. This alteration may, in part, be the cause of the proteinuria associated with diabetic nephropathy. 9 10 1991 11 12 2008 Diabetes mellitus Heparan sulfate proteoglycan Glomerular basement membrane...

... glomerular basement membrane (GBM) permeability and for effects on anionic sites in the GBM. Supernatants from cultures of concanavalin A-stimulated peripheral blood mononuclear cells from patients with MCNS, those with FSGS and normal controls were infused into the renal arteries of normal rats. Infusion...

... on the development of the glomerular basement membrane (GBM). Pregnant Wistar female rates were treated with gentamicin. Deliveries occurred normally. Using electron microscopy, we looked at the deepest glomerules of the kidneys of 1-day-old neonates: myeloid bodies were found in podocytes, and the GBM appeared...

... for immunoglobulins G. M and A. and Cj. Electron microscopy showed no electron-dense deposits or splitting of the glomerular basement membrane (GBM). In 1987, the radial nerve sensory branch was found to be thick­ ened, there was distal wasting in the arms as well as in the legs, and areflexia was now complete...

... was not significantly different in the groups. Renal pathological lesions in the control diabetic mice showed glomerular mesangial expansion and on electron microscopy thickened glomerular basement membranes with a mean thickness of 3,204 ± 186 Å. Treated animals showed significantly less mesangial crescents...

... was unaffected. Ultrastructural examination revealed that the thickness of glomerular basement membrane was markedly thinner in the OKY-046-treated diabetic rats than in the untreated diabetics (197.4 ± 29.6 vs. 288.6 ± 46.9 nm, p < 0.01). These results suggest that thromboxane A 2 may play an important role...