... at risk of AKI. Whether present patient characteristics and management have changed this risk is uncertain. We determined the current incidence, risk factors and outcomes of AG-AKI. Methods: We retrospectively identified adult patients who received gentamicin or tobramycin for ≥5 days in 2 large...

...Jonathan Purnell; Donald C. Houghton; George A. Porter; William M. Bennett Potassium and magnesium deficiency have been reported as risk factors for experimental gentamicin nephrotoxicity. Amiloride, a potassium-sparing diuretic, also leads to increased renal magnesium reabsorption. Amiloride, 2 mg...

...Masaaki Ishibashi; Fumiaki Yamasaki; Masanori Nakakuki; Tomoaki Shinkawa; Masahiro Mizota The cytoprotective effect of ulinastatin was studied in LLC-PK 1 cells treated with antimycin A, gentamicin, or cisplatin. All of the three agents induced a concentration-dependent increase in the release...

... Aminoglycosides Gentamicin Kidney NEPHRON Original Paper Nephron 1977;77:205-211 Accepted: March 10. 1997 Francisco J. Gainzaa Jose I. Mingúela3 Ildefonso Lampreabeab Nephrology Department, Hospital de Cruces, Barakaldo-Bizkaia, Basque Country University School of Medicine. Bilbao. Basque Country. Spain...

..., GSH-Px; catalase, CAT) were measured in kidney tissues from guinea pigs treated with gentamicin alone (200 mg/kg/day), gentamicin plus vitamin C (600 mg/kg/day), gentamicin plus vitamin E (400 mg/kg/day), and gentamicin plus vitamins C and E together for 10 days, and from animals treated...

...Lina Rivas-Cabañero; Alicia Rodriguez-Barbero; Miguel Arévalo; José Miguel López-Novoa The present experiments were designed to assess the effect of inhibiting NO synthesis on the renal failure induced in rats by treatment with high doses of gentamicin. Eighteen Wistar rats were given gentamicin...

...B.J. Smyth; W.G. Davis Recent research suggests the involvement of hydroxyl and superoxide free radicals in the development of gentamicin-induced acute renal tubular necrosis. Xanthine oxidase has been implicated as an important source of superoxide free radicals. Spontaneously hypertensive (Wistar...

...Mahmoud M. Farag; Mona Kandil; Geylan A. Fadali The effect of verapamil on the nephrotoxic potential of gentamicin was examined in rats. Rats were injected with one of the two or both drugs for 6 days and sacrificed 48 h after the last injection. In verapamil-treated rats (5 mg/kg/day...

...Hajime Nakahama; Masahiro Kakihara; Yoshifumi Fukuhara; Naohiko Veda; Yoshimasa Orita; Takenobu Kamada Parathyroidectomy is proposed to be protective against gentamicin nephrotoxicity in rats. In the present study, we evaluated the effects of bovine PTH(1-34) on gentamicin accumulation in cultured...

...Masaaki Ishigami; Masanobu Eguchi; So Yabuki The authors investigated the protective effects of the urinary trypsin inhibitor urinastatin on acute renal failure induced in rats by gentamicin (240 mg/kg body weight i.p. for 3 days) and by mercuric chloride (3 mg/kg s.c.). In rats injected...

...Hajime Nakahama; Yoshifumi Fukuhara; Yoshimasa Orita; Atushi Yamauchi; Toshiro Takama; Takenobu Kamada Furosemide is known to potentiate gentamicin nephrotoxicity. The mechanism of potentiation is unclear. In our previous studies, we demonstrated that furosemide enhanced gentamicin accumulation...

...Norman L.M. Wong; Alex B. Magil; John H. Dirks Clearance experiments were conducted with metabolic cages to determine the effect of dietary magnesium on gentamicin nephrotoxicity. Three groups of male Wistar rats were given low, medium- or high-magnesium diets. Following baseline clearances...

...Terezila M. Coimbra; João-José Lachat Gentamicin doses of 40 mg/kg body weight/day were administered intravenously to 62 Wistar rats. Nineteen animals were also treated orally with an NaHCO 3 solution in place of water. The gentamicin-treated animals showed increased albuminuria immediately after...

...Farahnak K. Assadi; Elizabeth Chow-Tung Increased levels of urinary β 2 -microglobulin (β 2 M) have been used as a marker of proximal tubular dysfunction in human neonates. To assess the value of β 2 M in the detection of early stages of tubular damage caused by gentamicin, renal handling of β 2 M...

...Suchati Indraprasit; Vivat Ukaravichien; Chalermsri Pummangura; Sming Kaojarern Gentamicin removal during intermittent peritoneal dialysis was studied in 13 uremic patients. The peak serum level after 80 mg of gentamicin intravenous drip was 6.00 ± 1.3 μg/ml with a serum half-life of 13.6 ± 4.07 h...

...James S. McNeil; Benjamin Jackson; Lee Nelson; Donald E. Butkus The effects of chronic gentamicin administration on renal function was studied in dogs receiving 4 mg/kg i. m. of gentamicin b. i. d. for 28 days. Administration of gentamicin resulted in a bimodal change in renal function. A decrease...

...D. de Rougemont; A. Oeschger; L. Konrad; G. Thiel; J. Torhorst; M. Wenk; P. Wunderlich; F.P. Brunner Acute renal failure was induced in rats by subcutaneous injection of 200 mg/kg body weight gentamicin on 3 consecutive days. Following the last gentamicin injection, the animals began to produce...

...Allen Sugarman; Robert S. Brown; Patricio Silva; Seymour Rosen Sprague-Dawley rats given gentamicin from 10 to 70 mg/kg/day for 9 days showed a linear decrease in glomerular filtration rate with increasing dose, paralleled by histologic changes of acute tubular necrosis and cast formation only...

...Ramon Patel; Arnold Savage A 57-year-old male developed hypomagnesemia, hypokalemia and hypocalcemia during the course of repeated gentamicin therapy. Renal wasting of magnesium and potassium was demonstrated. Associated endocrine abnormalities included decreased level of serum immunoreactive...

...Miriam A. da Silva Trevisan; José Lopes de Faria A case of diffuse and bilateral necrosis of the renal medulla in an infant aged 2½ months is reported. The possible causes of such severe lesion are discussed. Gastroenteritis, hypotensive state and use of a nephrotoxic drug (gentamicin...