...-collapsing forms of focal segmental glomerulosclerosis may both be caused by pathogenic variants in the same genes, but there is less information on genetics of the former disease. We hypothesized that different hits (viral infection and genetic variants) may be involved in the development of a familial CG...

...Guoyong Liu; Liyu He; Xiaomeng Yang; Lingling Tang; Wei Shi; Jian She; Jiali Wei Introduction: Focal segmental glomerulosclerosis (FSGS) is characterized by focal and segmental obliteration of glomerular capillary tufts with increased matrix and usually associated with nephrotic range proteinuria...

... diagnoses, and long-term renal outcomes of iSRNS patients for 30 years. Results: Of 516 patients with idiopathic NS, 52 (10.1%) had iSRNS. Renal biopsies from 48 patients showed minimal change disease (MCD) in 23 (47.9%), focal segmental glomerulosclerosis in 24 (50.0%), and mesangioproliferative...

... transcription factor that functions in glomerular podocytes, macrophages, and osteoclasts. Recently, MAFB was identified as the gene that was responsible for causing nephropathy with focal segmental glomerulosclerosis (FSGS) with multicentric carpotarsal osteolysis (MCTO) or Duane retraction syndrome (DRS...

...Jun Shoji; Akiko Mii; Mika Terasaki; Akira Shimizu Background: Focal segmental glomerulosclerosis (FSGS) is a clinicopathological syndrome characterized by nephrotic-range proteinuria with high incidence of progression to end-stage renal disease (ESRD). In primary FSGS, 40–60% of patients develop...

... syndrome with microscopic haematuria, after he developed proteinuria and haematuria at 28 years of age. His renal function deteriorated (serum Cr = 1.3 mg/dL). A percutaneous renal biopsy was performed at 61 years of age, and a focal segmental glomerulosclerosis (FSGS)-like lesion with endocapillary...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Collapsing glomerulopathy Focal segmental glomerulosclerosis Autoimmune lymphoproliferative disorder Interferon gamma Double negative T cell National Institutes of Health...

...Amir Shabaka; Ana Tato Ribera; Gema Fernández-Juárez Focal segmental glomerulosclerosis (FSGS) is a histological pattern of glomerular injury, rather than a single disease, that is caused by diverse clinicopathological entities with different mechanisms of injury with the podocyte as the principal...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Action myoclonus renal failure SCARB2 Focal segmental glomerulosclerosis Electron microscopy Action myoclonus...

... 2017 were selected and patients with minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS) in the same period were selected as controls. Results: Overall, 267 patients with MN and 131 patients with MCD/FSGS ( n = 101 MCD and n = 30 FSGS) were analyzed. There was a significant...

...Rozemarijn Snoek; Tri Q. Nguyen; Bert van der Zwaag; Arjan D. van Zuilen; Hannah M.E. Kruis; Liesbeth A. van Gils-Verrij; Roel Goldschmeding; Nine V.A.M. Knoers; Maarten B. Rookmaaker; Albertien M. van Eerde Focal segmental glomerulosclerosis (FSGS) is a histological pattern of podocyte...

...Guoyong Liu; Liyu He Background: Focal segmental glomerulosclerosis (FSGS) is a common histologic pattern of kidney injury, which may eventually lead to end-stage renal disease. Objectives: Salidroside (SAL, p-hydroxyphenyl-β-D-glucoside) is an active component isolated from Rhodiolarosea, which...

... resistance, refractory nephrotic syndrome, and autoimmune disease. However, long-term CNI use causes nephrotoxicity, the features of which are arteriolar hyalinosis, tubular atrophy, striped interstitial fibrosis, and focal segmental glomerulosclerosis (FSGS). We investigated whether FSGS in CNI-induced...

... is induced by focal segmental glomerulosclerosis (FSGS). Methods: We established the NEP25 mouse model in which FSGS-hyperphosphatemia is induced by podocyte injury and evaluated the effect of a Pi binder, sevelamer. Results: After disease induction, we confirmed a gradual increase in serum Pi accompanied...

...Kaori Narumi; Eikan Mishima; Yukako Akiyama; Tetsuro Matsuhashi; Takashi Nakamichi; Kiyomi Kisu; Shuhei Nishiyama; Hajime Ikenouchi; Akio Kikuchi; Rumiko Izumi; Mariko Miyazaki; Takaaki Abe; Hiroshi Sato; Sadayoshi Ito Focal segmental glomerulosclerosis (FSGS) is caused by various etiologies...

... endothelial cell differentiation. Kidney Int 2005;67:1668-1671. 2. Pavenstädt H, Kriz W, Kretzler M: Cell biology of the glomerular podocyte. Physiol Rev 2003;83:253-307. 3. D'Agati VD: The spectrum of focal segmental glomerulosclerosis: new insights. Curr Opin Nephrol Hypertens 2008;17:271-281. 4...

... NS, Wilms tumor, and urogenital malformation in males. However, the role of WT1 mutations in adult-onset focal segmental glomerulosclerosis (FSGS) is unclear. We report the case of a 38-year-old female with FSGS. She had been diagnosed with streak ovaries during diagnostic workup for infertility...

... and M-genotype at residue 55 and A and B at site 192, respectively. We have studied the association between PON1 gene polymorphisms and the minimal change nephrotic syndrome/focal segmental glomerulosclerosis (MCNS/FSGS) types of idiopathic nephrotic syndrome (INS) in Kuwaiti Arab children. Methods...

... molecular genetics approach that revolutionised their investigation and proved particularly instrumental, especially, in many not so clear-cut cases. More recently, the spectrum of COL4N has expanded to include late onset focal segmental glomerulosclerosis (FSGS) that develops on top of TBMN in later life...

...Charalambos Stefanou; Myrtani Pieri; Isavella Savva; Georgia Georgiou; Alkis Pierides; Konstantinos Voskarides; Constantinos Deltas Background/Aims: A subset of patients who present with proteinuria and are diagnosed with focal segmental glomerulosclerosis (FSGS) have inherited heterozygous COL4A3...