..., instructions or products referred to in the content or advertisements. 2024 Tight junction Kidney disease Claudin-1 Fibrosis Kidney disease is a growing global problem and the proportion of deaths due to kidney disease has increased steadily over the past 2 decades [ 1 ]. Indeed, premature...

...Alexander L. Bullen; Sucheta Vaingankar; Magdalena Madero; Salvador Lopez Gil; Etienne Macedo; Joachim H. Ix; Dena E. Rifkin; Pranav S. Garimella Background: Interstitial fibrosis and tubular atrophy (IFTA) are common findings on biopsy in chronic kidney disease (CKD) and are strongly predictive...

... disease Cilia Fibrosis Planar cell polarity NIH The cilium is a membrane-bound, hair-like structure protruding from the surface of a cell. There are two types of cilia, i.e., motile cilia and immotile cilia. Immotile cilia are also called primary cilia with a few hundred nanometers...

...; and (3) downstream effects of genetic inhibition of ATR in the proximal tubule, leading to maladaptive repair, fibrosis, and CKD. [email protected] 25 05 2021 17 08 2021 14 10 2021 In another model of injury, ischemia/reperfusion injury (IRI), we also found enhanced...

...Luca Bordoni; Donato Sardella; Ina Maria Schiessl Acute kidney injury (AKI) is associated with an increased risk of CKD. Injury-induced multifaceted renal cell-to-cell crosstalk can either lead to successful self-repair or chronic fibrosis and inflammation. In this mini-review, we will discuss...

...Monica Cortinovis; Sistiana Aiello; Marilena Mister; Karin Conde-Knape; Marina Noris; Rubina Novelli; Samantha Solini; Pamela Y. Rodriguez Ordonez; Ariela Benigni; Giuseppe Remuzzi Background: Tissue fibrosis is the final common phase of chronic allograft injury, the leading cause of late graft...

... acute tubular injury (ATI) does not have any disease-specific therapies. Failure to distinguish AIN from ATI in a timely manner can lead to kidney fibrosis and chronic kidney disease. In this review, we discuss current tests and novel biomarkers to distinguish ATI from AIN. Summary: In a prospective...

... 2018 Kidney Laser microdissection Nephrotoxic nephritis Inflammation Fibrosis Iron © 2018 S. Karger AG, Basel 2018 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any...

... models and clinical nephrology. Methods: A literature search was performed in PUBMED, ScienceDirect, between January 1957 and March 2017 using the following keywords: “metformin,” “nephroprotection,” “renoprotection,” “survival,” “renal failure,” “chronic kidney diseases,” “fibrosis,” “polycystic kidney...

...Benjamin A. Vervaet; Lies Moonen; Lode Godderis; Katrien Poels; Patrick C. D'Haese Background: Current treatment options for chronic kidney disease (CKD) are limited and their focus is on slowing its progression by addressing comorbidities. Fibrosis, the common histopathological process in CKD...

... limited. DDR1 has been widely studied in several types of cancers, in atherosclerosis and fibrosis, but also in chronic kidney disease (CKD). This review focuses on the role of DDR1 in chronic nephropathies and on the effect of its deletion in the pathological processes involved in renal disease...

... renal failure Fibrosis Ischemia-reperfusion injury Acute kidney injury (AKI) and chronic kidney disease (CKD) are both precursors to end-stage renal disease (ESRD), which led to over 46,000 deaths in 2013 [ 1 ]. While some patients with AKI make an apparent full recovery, many others, perhaps...

...Cong-hui Wang; Zheng Wang; Li-juan Liang; Xiang-ting Wang; Xue-lian Ma; Bei-bei Liu; Jia-qi He; Tatsuo Shimosawa; Qing-you Xu Background: The unilateral ureteral obstruction (UUO) model not only induces renal interstitial fibrosis in the obstructed kidney but also induces injury...

... and kidney fibrosis. In this study, we extend this to an assessment of transcriptional regulation of the entire TGF-β superfamily in kidneys from diabetic vs. healthy mice. In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related...

... 14 days. To induce CKD with tubulointerstitial fibrosis, 3 mg/kg AAI were administered every 3 days for 6 weeks followed by 6 weeks remodeling time. The mice exhibited increased levels of serum creatinine and BUN, reduced kidney weight, tubulointerstitial fibrosis (more severe in male mice), elevated...

... erythematosus Lupus nephritis Hypertension Podocyte Tubule Immune Inflammation Fibrosis Mitotic spindle Cell division Semaphorins comprise a family of membrane-bound or diffusible factors that were initially discovered for their role as axon guidance cues in the developing nervous system...

...Stuart William Smith; Adam Paul Croft; Hannah Louise Morris; Amy Jane Naylor; David Leonard Huso; Clare Marie Isacke; Caroline Olivia Susan Savage; Christopher Dominic Buckley Background: Tissue fibrosis and microvascular rarefaction are hallmarks of progressive renal disease. CD248...

...Armando Di Donato; Gian Marco Ghiggeri; Marco Di Duca; Elena Jivotenko; Roberto Acinni; Jonica Campolo; Fabrizio Ginevri; Rosanna Gusmano Collagen cross-linking induced by lysyl oxidase has been implicated in liver and lung fibrosis. To define the role of this process in kidney fibrosis, we...

...Lene Heickendorff; Lars Frost; Jens K. Madsen; Erling B. Pedersen Chronic cyclosporine nephrotoxicity is characterized morphologically by cortical interstitial fibrosis. The most important collagens involved in renal fibrosis are collagen types I and III. In order to estimate the synthesis of type...

...Ulrike Eismann; Manfred Sommer; Hartwig Kosmehl; Dorothea Appenroth; Christian Fleck; Günter Stein Background/Aims: Renal interstitial fibrosis (RIF) is the main cause for progressive renal failure, but its pathogenic factors are not well known. In animal models of renal fibrogenesisdone thus far...