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Keywords: Fibrosis
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Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron 1–5.
Published Online: 01 December 2023
...Alexander L. Bullen; Sucheta Vaingankar; Magdalena Madero; Salvador Lopez Gil; Etienne Macedo; Joachim H. Ix; Dena E. Rifkin; Pranav S. Garimella Background: Interstitial fibrosis and tubular atrophy (IFTA) are common findings on biopsy in chronic kidney disease (CKD) and are strongly predictive...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2023) 147 (12): 721–724.
Published Online: 17 July 2023
... disease Cilia Fibrosis Planar cell polarity NIH The cilium is a membrane-bound, hair-like structure protruding from the surface of a cell. There are two types of cilia, i.e., motile cilia and immotile cilia. Immotile cilia are also called primary cilia with a few hundred nanometers...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2022) 146 (3): 274–277.
Published Online: 14 October 2021
...; and (3) downstream effects of genetic inhibition of ATR in the proximal tubule, leading to maladaptive repair, fibrosis, and CKD. jbonventre@bwh.harvard.edu 25 05 2021 17 08 2021 14 10 2021 © 2021 S. Karger AG, Basel 2021 Copyright / Drug Dosage / Disclaimer Copyright...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2020) 144 (12): 650–654.
Published Online: 30 June 2020
...Luca Bordoni; Donato Sardella; Ina Maria Schiessl Acute kidney injury (AKI) is associated with an increased risk of CKD. Injury-induced multifaceted renal cell-to-cell crosstalk can either lead to successful self-repair or chronic fibrosis and inflammation. In this mini-review, we will discuss...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2020) 144 (1): 38–48.
Published Online: 24 September 2019
...Monica Cortinovis; Sistiana Aiello; Marilena Mister; Karin Conde-Knape; Marina Noris; Rubina Novelli; Samantha Solini; Pamela Y. Rodriguez Ordonez; Ariela Benigni; Giuseppe Remuzzi Background: Tissue fibrosis is the final common phase of chronic allograft injury, the leading cause of late graft...
Journal Articles
Journal: Nephron
Nephron (2019) 143 (3): 211–216.
Published Online: 14 June 2019
... acute tubular injury (ATI) does not have any disease-specific therapies. Failure to distinguish AIN from ATI in a timely manner can lead to kidney fibrosis and chronic kidney disease. In this review, we discuss current tests and novel biomarkers to distinguish ATI from AIN. Summary: In a prospective...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2018) 138 (4): 261–274.
Published Online: 14 December 2017
... models and clinical nephrology. Methods: A literature search was performed in PUBMED, ScienceDirect, between January 1957 and March 2017 using the following keywords: “metformin,” “nephroprotection,” “renoprotection,” “survival,” “renal failure,” “chronic kidney diseases,” “fibrosis,” “polycystic kidney...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2017) 137 (3): 212–220.
Published Online: 26 July 2017
... limited. DDR1 has been widely studied in several types of cancers, in atherosclerosis and fibrosis, but also in chronic kidney disease (CKD). This review focuses on the role of DDR1 in chronic nephropathies and on the effect of its deletion in the pathological processes involved in renal disease...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2017) 137 (4): 264–267.
Published Online: 09 June 2017
... renal failure Fibrosis Ischemia-reperfusion injury Acute kidney injury (AKI) and chronic kidney disease (CKD) are both precursors to end-stage renal disease (ESRD), which led to over 46,000 deaths in 2013 [ 1 ]. While some patients with AKI make an apparent full recovery, many others, perhaps...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2016) 133 (1): 53–61.
Published Online: 24 May 2016
.... This review serves to provide a comprehensive overview of interventional mouse models of acute and chronic kidney disease. Fibrosis Mouse Kidney disease Mouse models Rodent models of kidney disease are essential to understand the impact of genetic factors on the manifestation and progression...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2016) 132 (2): 93–100.
Published Online: 05 February 2016
...-induced effects in neurons [ 11 ] show less albuminuria, attenuated glomerulosclerosis and interstitial fibrosis, and a decrease in macrophage infiltration and in the renal expression of pro-inflammatory and pro-fibrotic genes, while kidney function is improved [ 9 ]. Interestingly, treatment of diabetic...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1997) 76 (2): 192–200.
Published Online: 23 December 2008
...Armando Di Donato; Gian Marco Ghiggeri; Marco Di Duca; Elena Jivotenko; Roberto Acinni; Jonica Campolo; Fabrizio Ginevri; Rosanna Gusmano Collagen cross-linking induced by lysyl oxidase has been implicated in liver and lung fibrosis. To define the role of this process in kidney fibrosis, we...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1994) 67 (2): 203–208.
Published Online: 17 December 2008
...Lene Heickendorff; Lars Frost; Jens K. Madsen; Erling B. Pedersen Chronic cyclosporine nephrotoxicity is characterized morphologically by cortical interstitial fibrosis. The most important collagens involved in renal fibrosis are collagen types I and III. In order to estimate the synthesis of type...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2002) 92 (2): 379–388.
Published Online: 02 September 2002
...Ulrike Eismann; Manfred Sommer; Hartwig Kosmehl; Dorothea Appenroth; Christian Fleck; Günter Stein Background/Aims: Renal interstitial fibrosis (RIF) is the main cause for progressive renal failure, but its pathogenic factors are not well known. In animal models of renal fibrogenesisdone thus far...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1998) 79 (4): 452–457.
Published Online: 29 July 1998
... and urine values of sodium and potassium as well as urinary protein/creatinine ratios. Yet histopathological examination of kidney tissues showed focal tubular atrophy and interstitial fibrosis in inner medulla and inner stripe of the outer medulla in all Cs-treated animals and in only 1 of the colchicine...