...Ernesto L. Schiffrin Subject of Review: Gupta et al. [Cell 2017; 170: 522–533] have shown that a genetic variant associated with the 5 vascular diseases is a distal regulator of endothelin (ET)-1 gene ( EDN1 ) expression. A common single nucleotide polymorphism (SNP) in the third intron...

... endothelin (ET) was measured before the induction of anesthesia, at the beginning and at the end of the clamp period and at the end of the operation. Intraoperatively, creatinine clearance and urinary excretion of PGE 2 , 6-keto PGF 1α and TxB 2 were also determined before, during and after aortic...

...), plasmin-α 2 -plasmin inhibitor complex (PIC), stabilized fibrin degradation product (D-dimer), and von Willebrand factor antigen determined by enzyme immunoassay, and endothelin 1 by radioimmunoassay with two antibodies. Preocclusion levels of PIC, D-dimer, von Willebrand factor, and endothelin 1 were...

... Endothelins (ETs) have been known to have a variety of biological functions such as mitogenic stimulation, natriuresis and the stimulation of the proteolytic activity in addition to vasoconstrictive action, which may participate in the process of glomerular diseases pathophysiologically...

... The present study was designed to assess how the renal expression of mRNA for endothelin (ET) families is regulated during compensatory renal hypertrophy in rats. ET family gene expression was studied in the contralateral kidney of uninephrectomized and sham-operated rats. Rats were sacrificed...

... mesangial cells. HUVEC released endothelin-1 (ET-1), and prostaglandin 12 (PGI 2 ). Ang II stimulated the production of PGI 2 , but did not modify that of ET-1. DNA synthesis in mesangial cells estimated by [ 3 H]-thymidine incorporation was increased when mesangial cells and endothelial cells were...

...David P. Brooks; P. Dennis DePalma The effect of the novel nonpeptide endothelin (ET) receptor antagonist, ( ± )-SB 209670, on the renal effects of the high osmolar tri-iodinated ionic contrast media, Hypaque, was evaluated in anesthetized dogs in the presence or absence of the cyclooxygenase...

... the prostaglandin E 2 excretion increased after ANP administration only in controls. Endothelin, angiotensin II, aldosterone, and arginine vasopressin were unchanged in the two groups. Basal aldosterone was lower and ANP higher in patients than in controls. In conclusion, the natriuretic effect of ANP was reduced...

...Esteban Poch; Wladimiro Jiménez; Faust Feu; Antonio Coca; Albert Botey; Jaume Bosch; Francisca Rivera; Luis Revert The aim was to investigate circulating levels of immunoreactive endothelin (ir-ET) in atherosclerotic renovascular hypertension (RVH), and to assess the role of the kidneys in its...

...) or endothelin (ET 1; 10 -6 M ) were added into the perfusate. Spontaneous ANF release by the atria of renal failure rats was significantly elevated compared to intact rats. A significant positive correlation was found between ANF release rate and BUN (r=0.65, p < 0.01). This suggests that the increase in ANF...

...D. Vlassopoulos; G. Deray; A. Carayon; G. Maistre; C. Jacobs We have determined the plasma levels of endothelin-1 (ET-1) in patients with end-stage renal disease treated with continuous ambulatory peritoneal dialysis (CAPD). In 10 CAPD patients mean plasma ET levels (7.01 ± 0.5 pg/ml) were found...

...Francesca Mallamaci; Saverio Parlongo; Carmine Zoccali To study the influence of cardiovascular damage on plasma endothelin in chronic renal failure, we have measured the plasma concentration of this peptide in 32 uremic patients (7 undialyzed uremics, 8 CAPD patients and 16 hemodialysis patients...

...Toshimitsu Niwa; Toshitaka Fujishiro; Kanji Uema; Tetsuya Tsuzuki; Yoshihiro Tominaga; Yutaka Emoto; Takashi Miyazaki; Kenji Maeda To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP...

... of endothelin and angiotensin II on renal hemodynamics in experimental nephritis induced by the administration of antithymocyte serum in Wistar rats. This model showed mesangiolytic lesions in the glomeruli on day 2 and hypercellular lesions on day 8. Prior to the injection of either endothelin or angotensin II...

...). The animals treated showed an increase in mean arterial pressure that was not present in the control group. Through their data, the authors suggest the vasopressor effect of erythropoietin. Furthermore, from other studies done before, they hypothesize that the vasoactive ability of the hormone is endothelin...

... none of the untreated patients developed hypertension during the study (Fisher’s exact test, p = 0.007). Plasma levels of the vasoactive hormones, atrial natriuretic peptide (ANP), plasma renin activity (PRA), and endothelin (ET) remained unchanged during both subcutaneous and intraperitoneal rHuEPO...

...Kenji Ando; Yukio Hirata; Yoshio Takei; Masaya Kawakami; Fumiaki Marumo By using a radioimmunoassay specific for endothelin-1 (ET-1), we studied whether ET-1-like immunoreactivity (LI) is present in human urine. Significant amounts of ET-1-LI were present in human urine, and the daily urinary...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Smoking Renal failure Primary renal disease Diabetic nephropathy Hypertension Endothelin A 42-year-old women was admitted to the renal outpatient clinic in April 1998...

... endothelin-1 synthesis in cultured endothelial cells in vitro. Methods: We investigated endothelin and cytokine levels in sera during a large outbreak of E. coli O157:H7 infection in Osaka, Japan, in 1996. Eleven patients with HUS and 9 patients with hemorrhagic colitis at the onset of E. coli O157:H7...

...Masood A. Khan; Mick R. Dashwood; Faiz H. Mumtaz; Cecil S. Thompson; Dimitri P. Mikhailidis; Robert J. Morgan Background/Aim: Nephropathy is an important complication of diabetes mellitus (DM). The plasma endothelin 1 (ET-1) levels are increased in DM, and ET-1 may cause deleterious effects...