...Pierre Delanaye; Etienne Cavalier; Thomas Stehlé; Hans Pottel Background: In daily practice, glomerular filtration rate (GFR) is estimated with equations including renal biomarkers. Among these biomarkers, serum creatinine remains the most used. However, there are many limitations with serum...

...Pierre Delanaye; Hans Pottel The new European Kidney Function Consortium (EKFC) creatinine-based equation has been developed to be applicable over the entire age range (from 2 to 100 years) without any loss of performance in young adults and without loss of continuity in estimating glomerular...

...Yao Ma; Lu Wei; Zhenzhu Yong; Yue Yu; Yi Chen; Bei Zhu; Weihong Zhao Background: Equations based on serum creatinine (SCr) have been extensively applied to estimate glomerular filtration rate (GFR), but their performance is debatable. In 2021, the European Kidney Function Consortium (EKFC...

.... Acute renal failure Chronic kidney disease Creatinine Since, severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) was reported in late December 2019, our understanding of coronavirus infection disease (COVID-19) has evolved. COVID-19 affects the respiratory system predominantly...

...Mina Khorashadi; Remi Beunders; Peter Pickkers; Matthieu Legrand Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not exclusively filtered by the kidney and rises...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Transplant Acute kidney injury Outcomes Creatinine Allograft Failure Clinical Practice: Mini-Review Nephron 2019;143:193 196 DOI: 10.1159/000500550 Acute Kidney...

...Nicholas M. Selby Context: International criteria for describing the presence and severity of acute kidney injury (AKI) based on changes in serum creatinine concentration and/or degree of oliguria are now widely accepted. Subject of Review: Three recent articles have debated the definition...

...Manohar Bairy; Faith H.W. See; Ru Sin Lim Background: Estimating the glomerular filtration rate (eGFR) when the creatinine (Cr) is rapidly changing, as in acute kidney injury (AKI), has been a challenge. The Kinetic Estimated Glomerular Filtration Rate (KeGFR) formula by S. Chen estimates the GFR...

... for the outcome of interest. Summary: In acute kidney injury (AKI), the 2 most common endpoints utilized either rely on small, short-term changes in serum creatinine or are a composite of longer term major adverse kidney events, including death, need for dialysis, and a persistent decline in kidney function. Key...

... Diabetic patients (n = 23) with chronic renal failure (CRF) accumulate the creatinine (Cr) oxidative metabolites creatol (CTL) and methylguanidine (MG; a uremic toxin) in their sera. Analysis of serum CTL, a key intermediate in mammalian Cr catabolism into MG, is shown to offer some useful...

... creatinine 394 ± 141 ml/min, KCn creatinine 6.03 ± 1.42 ml/kg/min, KC phosphate 369 ± 132 ml/min, KCn phosphate 5.62 ± 1.24 ml/kg/min. KC was significantly correlated to weight for all three substances, but no correlation was seen between KCn and weight, height, age, sex, uremia duration or dialysis duration...

... plasma creatinine were assessed in 8 patients before and during treatment with the nephrotoxic antitumor agent cis -platin. Plasma creatinine increased during treatment with cis -platin. In all patients, acute tubular damage was revealed by early RFP. Albumin and total protein excretion patterns...

...Ko Nakamura; Kazuharu Ienaga; Koji Nakano; Masahiko Nakai; Yoshio Nakamura; Goji Hasegawa; Manabu Sawada; Motoharu Kondo; Hiroshi Mori; Takahiro Kanatsuna Analysis of creatoi (CTL, 5-hydroxycreatinine), an oxidative creatinine (Cr) metabolite, in serum and urine of human subjects has indicated...

...Jürgen Holtz; Thomas Munzel; Olaf Sommer; Eberhard Bassenge We analyzed the effect of enalapril (0.1 mg/kg p.o. twice daily) on plasma electrolytes, urea, and creatinine in low cardiac output failure. In 14 male dogs implanted with chronic instrumentation, tachycardia was induced by ventricular...

...B.A.C. van Acker; M.F. Prummel; J.A. Weberc; W.M. Wiersinga; L. Arisz To clarify the rise in plasma creatinine concentration previously observed during prednisone treatment, we studied changes in renal function in Graves’ ophthalmopathy patients before and after 2 weeks of either prednisone 60 mg...

... analysis. ‘Uremic sera’, creatinine, urea, and combinations of these compounds reduce inotropy of the cultured heart cells, induce arrhythmias or asynchronies in a concentration-dependent manner. We propose the myocyte perfusion technique as an in vitro approach to identify cardiotoxins in the body fluids...

...Takako Yokozawa; Hikokichi Oura; Kazuharu Ienaga; Ko Nakamura Creatinine (Cr), creatol and methylguanidine (MG), which accumulate in the body with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine...

... produced from creatinine mainly by reaction with hydroxyl radicals. This enzyme has been indentified as L -gulono-γ-lactone oxidase (EC 1.1.3.8). However, no corresponding activity was found in extracts from human livers. 27 03 1992 12 12 2008 © 1993 S. Karger AG, Basel 1993 Copyright...

... to the preinfusion level of proteinuria. Furthermore, the ratio of urinary protein to creatinine was significantly elevated by about 250% in the three groups. Thus, ANP seems to increase the permeability of the glomerular basement membrane to protein, particularly in patients with DGN, possibly through mesangial...

...Ko Nakamura; Kazuharu Ienaga; Takako Yokozawa; Naoki Fujitsuka; Hikokichi Oura The chemical oxidative conversion of creatinine (Cr) into methylguanidine (MG) has been followed by ‘H-NMR and HPLC. By using active oxygen species generated by Fenton’s reagent (Fe 2+ and H 2 O 2 ) or the similar...