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Keywords: Complement
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Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2023) 147 (1): 17–20.
Published Online: 14 February 2023
.... This pattern is consistent with complement activation and uncontrolled inflammation, two features of endotoxemia. Unbiased discovery using artificial intelligence also identifies a subtype of sepsis which features these same organ failures. Conclusion: Endotoxin appears to represent an important molecular...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2020) 144 (Suppl. 1): 2–6.
Published Online: 25 November 2020
...Iwasaki Kenta; Kobayashi Takaaki Antibody-mediated rejection (ABMR) in organ transplantation has been recognized as the main cause of graft rejection. Binding of donor-specific HLA antibody (DSA) and A/B blood type antibody on graft endothelial cells causes complement-dependent tissue damage. C4d...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2020) 144 (Suppl. 1): 7–12.
Published Online: 24 November 2020
...Katsuki Ohtani Complement has been considered to be a factor that protects the host against invading microorganisms during infection. However, in recent years, complement-related protein deficiency has been found to be involved in the onset of various diseases, such as autoimmune and inflammatory...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2020) 144 (11): 537–549.
Published Online: 18 September 2020
... commonly affecting the kidney. Diagnosis is clinical, after exclusion of other TMA causes. Primary aHUS arises from genetic abnormalities, resulting in uncontrolled complement activity, while a variety of clinical scenarios cause secondary aHUS, including infection, pregnancy, malignancy, autoimmune...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2019) 142 (3): 264–270.
Published Online: 19 March 2019
... number variation analysis uncovered 4 copies of complement factor H related genes, CFHR1 - CFHR4 , conceivably leading to higher than normal levels of the corresponding proteins. However, this abnormality was also found in the healthy relatives, neither explaining the disease nor the excessive complement...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2019) 142 (3): 253–257.
Published Online: 14 March 2019
... can therefore be missed, affecting outcomes. We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2016) 132 (1): 5–14.
Published Online: 23 December 2015
...Simon W. Lines; Victoria R. Richardson; Bryn Thomas; Emma J. Dunn; Mark J. Wright; Angela M. Carter Background: Patients on haemodialysis (HD) have high rates of cardiovascular (CV) disease and activation of the complement system. Despite evidence in non-renal patients that these may be linked...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1997) 76 (3): 276–283.
Published Online: 23 December 2008
... tissue complement gene expression could contribute to the pathogenesis of immune complex injury. In this study, we investigated the synthesis of complement proteins in glomerular epithelial cells (GECs) and its regulation. Using biosynthetic labelling, immunoprecipitation and sodium dodecyl sulfate...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1992) 62 (3): 296–299.
Published Online: 12 December 2008
.... There was a statistically significant association between the white blood cell count (WBC) and the level of the third component of the complement system (C 3 ). Children with both a low C 3 and a high WBC were significantly younger and required hospitalization for a significantly longer period of time. Although there were...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1989) 52 (1): 29–35.
Published Online: 10 December 2008
...J.A. Savige; A.C. Dash; A.J. Rees The mechanisms by which intercurrent bacterial infections are associated with increased tissue injury in some forms of glomerulonephritis may include complement activation by bacteria and subsequent increased glomerular neutrophil (PMN) infiltration. We have...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1989) 52 (2): 119–124.
Published Online: 10 December 2008
... patients are primed for an enhanced respiratory burst before dialysis is initiated. Dialysis-induced complement activation after the initiation of dialysis does not further stimulate H 2 O 2 production or enhance the response to phagocytosis. However, complement activation may cause leukopenia and CR3...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1987) 47 (1): 56–61.
Published Online: 05 December 2008
...Takayuki Fujita; Hiroyuki Ohi; Masato Seki; Hidenao Miyaji; Michinobu Hatano A unique factor causing breakdown of the third component of complement (C3) was detected in a patient with acute glomerulonephritis (AGN). The activity was detected by conversion of C3 in a mixture with normal human serum...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1987) 46 (2): 182–187.
Published Online: 05 December 2008
... more precise correlations between immunopathologic and morphologic findings in glomeruli. This technique could detect immunoglobulins (IgG, IgA, and IgM), complement factor (C3c), and fibrinogen-related antigen. The immunoreactivity of these antigens was essentially confined to the mesangial...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1984) 38 (2): 138–143.
Published Online: 04 December 2008
..., in a functional assay, are lower than one would expect from their immunochemical level, resulting in an abnormally low C4 hemolytic efficiency. This feature occurs in the absence of any other evidence of complement dysfunction. Similar abnormalities were not seen in patients with other hypocomplementemic renal...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1982) 32 (1): 63–66.
Published Online: 03 December 2008
... Eosinophilia Hemodialysis Complement © 1982 S. Karger AG, Basel 1982 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1979) 23 (5): 218–222.
Published Online: 02 December 2008
...Allen R. Nissenson; Laverne E. Rice; Elizabeth V. Potter; Antonio Quintanilla; Martha A. Shaughnessy; Murray L. Levin Complement levels were determined in 12 normal human volunteers while receiving intravenous infusions of inulin for determination of standard inulin clearances. Significant...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1979) 23 (4): 162–168.
Published Online: 02 December 2008
... Complement Fluorescence microscopy Kidney biopsy Original Papers Nephron 23; 162-168(1979) Immunological and Bacteriological Studies in Chronic Pyelonephritis Associated with Kidney Stones1 F. P. Schena, F. P. Selvaggi, C. Salvatore, S. Barbuti, F. Marzullo, A. Tallar¡go and L. Bonomo Clínica Medica 11...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1981) 27 (2): 79–83.
Published Online: 02 December 2008
... by factors present in the plasma, thought to be complement components activated by the dialysis coil. In the present study, an assay of plasma for adherence-augmenting activity shows that it is maximal at 15 min after starting dialysis, and undetectable at 40 min. The factor is not affected by heating to 56...