.... This pattern is consistent with complement activation and uncontrolled inflammation, two features of endotoxemia. Unbiased discovery using artificial intelligence also identifies a subtype of sepsis which features these same organ failures. Conclusion: Endotoxin appears to represent an important molecular...

...Iwasaki Kenta; Kobayashi Takaaki Antibody-mediated rejection (ABMR) in organ transplantation has been recognized as the main cause of graft rejection. Binding of donor-specific HLA antibody (DSA) and A/B blood type antibody on graft endothelial cells causes complement-dependent tissue damage. C4d...

...Katsuki Ohtani Complement has been considered to be a factor that protects the host against invading microorganisms during infection. However, in recent years, complement-related protein deficiency has been found to be involved in the onset of various diseases, such as autoimmune and inflammatory...

... commonly affecting the kidney. Diagnosis is clinical, after exclusion of other TMA causes. Primary aHUS arises from genetic abnormalities, resulting in uncontrolled complement activity, while a variety of clinical scenarios cause secondary aHUS, including infection, pregnancy, malignancy, autoimmune...

... number variation analysis uncovered 4 copies of complement factor H related genes, CFHR1 - CFHR4 , conceivably leading to higher than normal levels of the corresponding proteins. However, this abnormality was also found in the healthy relatives, neither explaining the disease nor the excessive complement...

... can therefore be missed, affecting outcomes. We present a case of chronic thrombotic microangiopathy (TMA) after kidney transplantation in a recipient who had been classified as hypertensive ESRD and found to have a genetic defect in CD46, a transmembrane protein that regulates complement activation...

...Simon W. Lines; Victoria R. Richardson; Bryn Thomas; Emma J. Dunn; Mark J. Wright; Angela M. Carter Background: Patients on haemodialysis (HD) have high rates of cardiovascular (CV) disease and activation of the complement system. Despite evidence in non-renal patients that these may be linked...

... tissue complement gene expression could contribute to the pathogenesis of immune complex injury. In this study, we investigated the synthesis of complement proteins in glomerular epithelial cells (GECs) and its regulation. Using biosynthetic labelling, immunoprecipitation and sodium dodecyl sulfate...

.... There was a statistically significant association between the white blood cell count (WBC) and the level of the third component of the complement system (C 3 ). Children with both a low C 3 and a high WBC were significantly younger and required hospitalization for a significantly longer period of time. Although there were...

...Michael Slater This study describes dense bodies seen in Bowman’s capsule and the glomerular basement membrane in biopsies of membranous glomerulonephritis. Within these bodies, silver-enhanced immunogold labelling demonstrated the presence of fibronectin and the complement component C3b...

...J.A. Savige; A.C. Dash; A.J. Rees The mechanisms by which intercurrent bacterial infections are associated with increased tissue injury in some forms of glomerulonephritis may include complement activation by bacteria and subsequent increased glomerular neutrophil (PMN) infiltration. We have...

... patients are primed for an enhanced respiratory burst before dialysis is initiated. Dialysis-induced complement activation after the initiation of dialysis does not further stimulate H 2 O 2 production or enhance the response to phagocytosis. However, complement activation may cause leukopenia and CR3...

...Takayuki Fujita; Hiroyuki Ohi; Masato Seki; Hidenao Miyaji; Michinobu Hatano A unique factor causing breakdown of the third component of complement (C3) was detected in a patient with acute glomerulonephritis (AGN). The activity was detected by conversion of C3 in a mixture with normal human serum...

... more precise correlations between immunopathologic and morphologic findings in glomeruli. This technique could detect immunoglobulins (IgG, IgA, and IgM), complement factor (C3c), and fibrinogen-related antigen. The immunoreactivity of these antigens was essentially confined to the mesangial...

...F.P. Schena; G. Pertosa; P. Stanziale; C. Germinario; M. Balletta; V.E. Andreucci Persistent activation of the complement system after escape from control by the regulatory proteins results in an excessive release of split products with inflammatory properties. Serum levels of the regulatory...

..., in a functional assay, are lower than one would expect from their immunochemical level, resulting in an abnormally low C4 hemolytic efficiency. This feature occurs in the absence of any other evidence of complement dysfunction. Similar abnormalities were not seen in patients with other hypocomplementemic renal...

... Eosinophilia Hemodialysis Complement © 1982 S. Karger AG, Basel 1982 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including...

... by factors present in the plasma, thought to be complement components activated by the dialysis coil. In the present study, an assay of plasma for adherence-augmenting activity shows that it is maximal at 15 min after starting dialysis, and undetectable at 40 min. The factor is not affected by heating to 56...

...F.P. Schena; G. Pertosa; E. Vox; L. Bonomo Activation of the alternative complement pathway (AP) has been investigated in 79 serial serum samples obtained from 28 patients which had different types of glomerulonephritis. Serum factors activating the AP of the complement system have been detected...

...Allen R. Nissenson; Laverne E. Rice; Elizabeth V. Potter; Antonio Quintanilla; Martha A. Shaughnessy; Murray L. Levin Complement levels were determined in 12 normal human volunteers while receiving intravenous infusions of inulin for determination of standard inulin clearances. Significant...