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Keywords: Collagen
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Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1995) 70 (1): 91–99.
Published Online: 18 December 2008
... activities on rat mesangial cell growth and collagen synthesis. Using cell counting and a modified MTT assay, it was shown that dipyridamole, pentoxifylline, dicentrine, prazosin and doxazosin all caused a dose-dependent inhibition of serum-stimulated rat mesangial cell proliferation. Platelet-derived growth...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1995) 71 (2): 197–202.
Published Online: 18 December 2008
... matrix protein synthesis by cultured rat mesangial cells. Mensangial cells were metabolically labeled with 35 S-methionine and specific extracellular matrix proteins were immunoprecipitated from supernatant and cellular fractions. The following extracellular proteins were assayed: type I collagen, type...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1995) 69 (2): 155–158.
Published Online: 17 December 2008
...M. Marx; G. Trittenwein; C. Aufricht; H. Hoeger; B. Lubec In the present study, we tested the hypothesis whether agmatine and spermidine, metabolites of arginine metabolism, share the pharmacological activities of argi- nine reducing collagen accumulation in the diabetic kidney. Eleven db/db mice...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1994) 66 (3): 333–336.
Published Online: 16 December 2008
...Barbara Lubec; A. Rokitansky; M. Hayde; C. Aufricht; U. Wagner; W.R. Mallinger; H. Höger; G. Lubec Glomerular basement membrane thickening and mesangial expansion are the main pathological features in diabetic nephropathy – glomerulosclerosis with the biochemical correlate of increased collagen...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1990) 56 (3): 281–284.
Published Online: 10 December 2008
... and thinner glomerular basement membrane thickness of 2,520 ± 252 Å (p < 0.01). The experimental animals showed in addition a lower mean kidney weight. Glomerular but not tubular proteinuria was reduced in the treated group. Basement membrane collagen type IV isolated from kidneys of experimental animals...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1988) 50 (4): 332–337.
Published Online: 09 December 2008
... of collagen type III by the affected kidney itself. 10 02 1988 9 12 2008 © 1988 S. Karger AG, Basel 1988 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1981) 29 (5-6): 205–208.
Published Online: 03 December 2008
... includes collagen, predominantly but not exclusively type IV, which is present as procollagen. Two glycoproteins, laminin and fibronectin, are either intrinsic components of the GBM or intimately associated with the membrane. Heparan sulfate, a glycosaminoglycan, is contained within the substance...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (1978) 21 (4): 230–235.
Published Online: 02 December 2008
...Karl Tryggvason; Kari I. Kivirikko The collagen component of isolated glomerular basement membrane was solubilized by limited pepsin digestion and further purified. The amino acid and carbohydrate composition of the final material was very similar to that described for the α 1 -chains of type IV...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2002) 92 (3): 693–698.
Published Online: 26 September 2002
...Jun Soma; Takashi Sugawara; Yee-Der Huang; Jun Nakajima; Minoru Kawamura Background: Tranilast, N-(3,4-dimethoxycinnamoyl) anthranilic acid, suppresses collagen synthesis by various cells, including macrophages and fibroblasts, by interfering with the actions of transforming growth factor-beta 1...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2002) 91 (4): 701–709.
Published Online: 15 July 2002
...Kristen J. Kelynack; Tim D. Hewitson; Marina Martic; Steven McTaggart; Gavin J. Becker Interstitial fibrosis is recognised as the best histological predictor of progressive renal disease. Myofibroblasts contribute to this process through several functions including hyperproliferation, collagen...
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2001) 88 (4): 347–353.
Published Online: 25 July 2001
... collagen production and matrix degradation. The aim of this study was to examine whether normal rat renal fibroblasts were capable of HA synthesis and to determine the effect of HA on in vitro collagen production in a series of normal rat cortical fibroblast cultures. Fibroblast cultures from both renal...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Journal: Nephron
Nephron (2000) 86 (3): 339–341.
Published Online: 08 November 2000
...M.S. Razzaque; N. Ahsan; T. Taguchi Heat shock protein 47 (HSP47) is a collagen-binding protein, thought to play an essential mechanistic role in the assembly and processing of procollagens. HSP47 is increasingly being implicated in the pathogenesis of several human and experimental fibrotic...
Journal Articles
Journal Articles