...Mengmeng Pu; Huanhuan Zhao; Silei Xu; Xiaohui Gu; Qiang Feng; Peng Huang Introduction: Sepsis-associated acute kidney injury (SA-AKI) is a common complication of sepsis. miR-340-5p has been identified as an effective biomarker of various human diseases. As the downstream target, the involvement...

...Mingjuan Yan; Ni Zhang; Li Quan; Wei Bin; Jing Xi; Caoshuai Dou; Zhiwen Liu; Yongfeng Gui; Liang-Hong Yin Introduction: Sepsis is the leading contributor to acute kidney injury (AKI), responsible for 45–70% of AKI occurrences. Despite this, septic AKI is a highly multifactorial and complex...

...Joseph Hunter Holthoff; Joseph L. Alge; John M. Arthur; Fatima Ayub; Wadhah Bin Homam; Michael G. Janech; Sreelakshmi Ravula; Nithin Karakala Introduction: Acute kidney injury (AKI) is associated with adverse outcomes, including death and dialysis. The goal of this study was to identify prognostic...

... bacteria. Described first by Adolf Weil in 1886, leptospirosis in Germany is rare, leading to a delayed diagnosis due to diverse symptoms. Most cases are mild, but severe forms, like Weil’s disease, cause life-threatening complications such as fever, jaundice, hemoptysis, and acute kidney injury (AKI...

...Supawadee Suppadungsuk; Charat Thongprayoon; Nasrin Nikravangolsefid; Waryaam Singh; Wisit Cheungpasitporn; Yue Dong; Kianoush B. Kashani Introduction: The association between magnesium level and progression to acute kidney disease (AKD) in acute kidney injury (AKI) patients was not well studied...

...Audrey Casemayou; Alexis Piedrafita; Rémi Engel; Guylène Feuillet; Melinda Alves; Ivan Tack; Julie Klein; Marie Buleon; Joost P. Schanstra; Stanislas Faguer Background: Chemokines orchestrate immune cells activation and infiltration during acute kidney injury (AKI). Objectives: We aim to test...

... that represents patients’ inflammation and nutritional status. Here, we aimed to investigate the prognostic value of CAR in critically ill patients with severe acute kidney injury requiring continuous renal replacement therapy (CRRT). Methods: We retrospectively collected data from eight tertiary hospitals...

... is detrimental [ 17, 18 ]. Excessive activation of mitophagy will cause a crisis of energy synthesis caused by a sharp decrease in the number of mitochondria, and cells will eventually succumb to lack of energy. Acute kidney injury (AKI) is a common clinical emergency characterized by a rapid decline...

...Jun Ge; Xuefeng Zhang; Ye Liu; Hang Liu; Xiaoming Liu Introduction: Acute kidney injury (AKI) is a common clinical disease, especially in the intensive care unit. Identification of reliable biomarker is of great clinical significance and benefit the therapy and prevention of AKI. The clinical...

... lacking. In chronic renal fibrosis, sympathetic nerve activation was demonstrated to be harmful by unilateral ureteral obstruction and post-ischemia reperfusion injury models. On the other hand, sympathetic nerve activation seemed protective in acute kidney injury models such as ischemia reperfusion...

...Javier A. Neyra; Orson W. Moe Acute kidney injury (AKI) is a highly prevalent condition with multiple acute and chronic consequences. Survivors of AKI are at risk of AKI-to-chronic kidney disease (CKD) transition, which carries significant morbidity and mortality. One retrospective analysis showed...

...Nuttha Lumlertgul; Lynda K. Cameron; Danielle E. Bear; Marlies Ostermann Acute kidney injury impacts the micronutrient status by various mechanisms including decreased enteral absorption, changes in redistribution, altered metabolism, and increased consumption. When renal replacement therapy (RRT...

...Audrey Shi; Sherry G. Mansour Background: Vascular biomarkers may explain the link between acute kidney injury (AKI) and poor long-term outcomes such as cardiovascular disease (CVD). Vessel injury is exceedingly common in AKI and contributes to the development of kidney fibrosis and CVD...

...Nabihah Amatullah; Britney A. Stottlemyer; Isabelle Zerfas; Cole Stevens; Tezcan Ozrazgat-Baslanti; Azra Bihorac; Sandra L. Kane-Gill Background: Drug-associated acute kidney injury (D-AKI) accounts for 19–26% of acute kidney injury (AKI) events in hospitalized patients and results in outcomes...

...Shina Menon; Katja M. Gist Acute kidney injury (AKI) is seen frequently in hospitalized patients and is associated with increased risk of mortality and adverse short- and long-term renal and systemic complications. Emerging data suggest that AKI is a heterogenous syndrome with a variety...

... among patients with CKD and at risk of cardiovascular events, lower tubular secretion was associated with an increased risk of acute kidney injury and metabolic acidosis, independent of baseline eGFR and albuminuria. The kidney tubules also play a crucial role in acid-base homeostasis. Although...

.... 2023 Acute kidney injury Biomaterials Cell therapy Hydrogels Kidney disease NIH While an array of non-injectable biomaterials exist, we have limited this review to injectable hydrogels that have been studied to treat kidney disease. The anatomical locations of both native...

...Lenar Yessayan; H. David Humes; Emily C. Scribe; Sai Prasad N. Iyer; Kevin K. Chung Introduction: NEUTRALIZE-AKI is a pivotal study to evaluate the safety and effectiveness of the selective cytopheretic device (SCD) in adult patients with acute kidney injury (AKI) requiring continuous kidney...

... progression. The kidney represents a prime target of age-associated organ damage. Dysregulated autophagy can cause or worsen acute kidney injury (AKI), diabetic nephropathy, polycystic kidney disease, and renal aging [ 6, 7 ]. The efficiency of autophagic cell repair is a direct determinant of cellular...

..., as well as podocytes. Treatment of acute kidney injury or chronic kidney disease (CKD) is complex due to broad etiopathogenic mechanisms and limited regeneration potential as kidney cells finish their differentiation after 34 weeks of gestation. Despite the ever-increasing prevalence of CKD, very limited...