... lacking. In chronic renal fibrosis, sympathetic nerve activation was demonstrated to be harmful by unilateral ureteral obstruction and post-ischemia reperfusion injury models. On the other hand, sympathetic nerve activation seemed protective in acute kidney injury models such as ischemia reperfusion...

...Javier A. Neyra; Orson W. Moe Acute kidney injury (AKI) is a highly prevalent condition with multiple acute and chronic consequences. Survivors of AKI are at risk of AKI-to-chronic kidney disease (CKD) transition, which carries significant morbidity and mortality. One retrospective analysis showed...

...Nuttha Lumlertgul; Lynda K. Cameron; Danielle E. Bear; Marlies Ostermann Acute kidney injury impacts the micronutrient status by various mechanisms including decreased enteral absorption, changes in redistribution, altered metabolism, and increased consumption. When renal replacement therapy (RRT...

...Audrey Shi; Sherry G. Mansour Background: Vascular biomarkers may explain the link between acute kidney injury (AKI) and poor long-term outcomes such as cardiovascular disease (CVD). Vessel injury is exceedingly common in AKI and contributes to the development of kidney fibrosis and CVD...

...Nabihah Amatullah; Britney A. Stottlemyer; Isabelle Zerfas; Cole Stevens; Tezcan Ozrazgat-Baslanti; Azra Bihorac; Sandra L. Kane-Gill Background: Drug-associated acute kidney injury (D-AKI) accounts for 19–26% of acute kidney injury (AKI) events in hospitalized patients and results in outcomes...

...Shina Menon; Katja M. Gist Acute kidney injury (AKI) is seen frequently in hospitalized patients and is associated with increased risk of mortality and adverse short- and long-term renal and systemic complications. Emerging data suggest that AKI is a heterogenous syndrome with a variety...

... among patients with CKD and at risk of cardiovascular events, lower tubular secretion was associated with an increased risk of acute kidney injury and metabolic acidosis, independent of baseline eGFR and albuminuria. The kidney tubules also play a crucial role in acid-base homeostasis. Although...

.... 2023 Acute kidney injury Biomaterials Cell therapy Hydrogels Kidney disease NIH While an array of non-injectable biomaterials exist, we have limited this review to injectable hydrogels that have been studied to treat kidney disease. The anatomical locations of both native...

...Lenar Yessayan; H. David Humes; Emily C. Scribe; Sai Prasad N. Iyer; Kevin K. Chung Introduction: NEUTRALIZE-AKI is a pivotal study to evaluate the safety and effectiveness of the selective cytopheretic device (SCD) in adult patients with acute kidney injury (AKI) requiring continuous kidney...

... oxygen species Acute kidney injury Chronic kidney disease DFG In 1955, Christian de Duve discovered and named the “lysosome,” for which he received the Nobel Prize in 1974. The process of transporting cellular cargo into the lysosome for degradation was termed “autophagy” (“self...

..., as well as podocytes. Treatment of acute kidney injury or chronic kidney disease (CKD) is complex due to broad etiopathogenic mechanisms and limited regeneration potential as kidney cells finish their differentiation after 34 weeks of gestation. Despite the ever-increasing prevalence of CKD, very limited...

...Michael Abel Alao; Olayinka Rasheed Ibrahim; Adebowale Dele Ademola; Adanze Onyenunachi Asinobi Introduction: Despite being a leading cause of morbidity and mortality globally, acute kidney injury (AKI) is worse in resource-limited areas. This study explores AKI incidence, inhospital mortality...

...Yu-Hsiang Chou; Tai-Shuan Lai; Yi-Chih Lin; Wen-Chih Chiang; Tzong-Shinn Chu; Shuei-Liong Lin; Yung-Ming Chen Introduction: Old age has been considered as a positive modifier of chronic kidney disease (CKD), but the progression of CKD is often accelerated by acute kidney injury (AKI) in older...

...Sian E. Piret Members of the Krüppel-like family of transcription factors are widely expressed, including in the kidney. Expression of some KLFs changes in acute kidney injury, and this may be adaptive or maladaptive, and result in effects on various cellular pathways. This mini-review...

...Boris Bikbov; Ida Fortino; Olivia Leoni; Alessandro Nobili; Mauro Tettamanti Background: Acute kidney injury (AKI) is a frequent condition, with persistent shortage of large-scale epidemiological studies. We analyzed the population-wide healthcare system of the Italian Lombardy region over the 2000...

...Zulihumaer Abuduwupuer; Qunjuan Lei; Shaoshan Liang; Feng Xu; Dandan Liang; Xue Yang; Xumeng Liu; Caihong Zeng Introduction: Acute kidney injury (AKI) is a group of highly heterogeneous, complicated clinical syndromes. Although kidney biopsy plays an irreplaceable role in evaluating complex AKI...

...Yusuke Takada; Kiyohiko Hotta; Kimihiko Moriya; Hajime Sasaki; Daiji Takamoto; Haruka Higuchi; Tatsu Tanabe; Keita Minami; Sari Iwasaki; Takahiro Tsuji; Hiroshi Tanaka Acute kidney injury (AKI) due to rhabdomyolysis occurs because of renal ischemia or acute tubular necrosis due to the deposition...

...Beatriz Sanchez-Alamo; Clara Cases-Corona; Gema Fernandez-Juarez Background: Acute interstitial nephritis (AIN) is one of the chief causes of acute kidney injury (AKI). AIN might be produced by drugs, infections, autoimmune diseases, or can be idiopathic. Among these etiologies, drug-induced AIN...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Acute kidney injury...

...Hernando Gómez Background: The recognition that sepsis induces acute kidney injury (AKI) in the absence of overt necrosis or apoptosis and even in the presence of increased renal blood flow has led to the consideration that kidney tubular epithelial cells (TECs) may deploy defense mechanisms...