We read the letter by Dr. Olivier Devuyst regarding the origin of cyst-lining cells in the kidneys of ADPKD. Their data confirm our data, which showed that the cyst-lining cells in ADPKD kidneys are well-differentiated in the terms of water channel (AQP-2 in the apical membrane and AQP-3 in the basolateral membrane) and that about 30% of the cyst originate from collecting-duct cells, although they did not examine the immunostaining of AQP-3. In addition to our data, they showed that AQP-1 also maintains its polarized distribution. Taken together, it is unlikely that polarity loss of the tubular epithelium is essential in the ADPKD kidney and that the major role of PKD genes is induction of cell polarity. On the other hand, the origin of about one third of the cysts, which do not express either AQP-1 or AQP2, remains to be determined.

Dear Sir,

We read the letter by Dr. Olivier Devuyst regarding the origin of cyst-lining cells in the kidneys of ADPKD. Their data confirm our data, which showed that the cyst-lining cells in ADPKD kidneys are well-differentiated in the terms of water channel (AQP-2 in the apical membrane and AQP-3 in the basolateral membrane) and that about 30% of the cyst originate from collecting-duct cells, although they did not examine the immunostaining of AQP-3. In addition to our data, they showed that AQP-1 also maintains its polarized distribution. Taken together, it is unlikely that polarity loss of the tubular epithelium is essential in the ADPKD kidney and that the major role of PKD genes is induction of cell polarity. On the other hand, the origin of about one third of the cysts, which do not express either AQP-1 or AQP2, remains to be determined. 

1997
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.