To evaluate the age-dependent phosphate homeostasis, we studied the serum inorganic phosphate (Pi) concentration in 78 recipients, aged 5–25 years, a year after renal transplantation (RT). The significant age-dependent decline of the serum Pi concentration was observed in recipients (p < 0.0001) as well as in normal children. Our study revealed that a circulating factor may play a central role in the age-dependent change of phosphate regulation in human.

Keywords:
Phosphate, PHEX gene, Development
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© 2002 S. Karger AG, Basel
2002
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