A 30-year-old white male presented with hematuria, proteinuria and normal renal function following a flu-like illness. IgA was mildly elevated but C3 and C4 levels were normal in serum. Renal biopsy showed a mesangial proliferative nephritis with immunohistochemical features of IgA nephritis but with an unusual pattern and distribution of deposits in glomerular, tubular and Bowman’s capsular basement membranes.

Berger J, Hinglais N: Les dépôts intercapillaires d’IgA-IgG. J Urol Nephrol (Paris) 1968;74:694–695.
Lai K-N, Chan KW, Lai FM-M, Ho CP, Yan KW, Lam CWK, Vallance-Owen J: The immunochemical characterization of the light chains in the mesangial IgA deposits in IgA nephropathy. Am J Clin Pathol 1986;85:548–551.
Rauterberg E, Lieberknecht H, Wingen A, Ritz E: Complement membrane attack (MAC) in idiopathic IgA-glomerulonephritis. Kidney Int 1987;31:820–829.
Davis AE, Schneeberger EE, McCluskey RT, Grupe WE: Mesangial proliferative glomerulonephritis with irregular intramembranous deposits. Another variant of hypocomplementemic nephritis. Am J Med 1977;63:481–487.
Galle P: Mise en évidence au microscope électronique d’une lésion singulière des membranes basales du rein et de la substance hyaline; Thèse Méd, Paris 1962.
Randall RE, Williamson WC Jr, Mullinax F, Tung M, Still WJS: Manifestations of systemic light chain deposition. Am J Med 1976;60:293–299.
Aucouturier P, Khamlichi AA, Touchard G, Justrabo E, Cogne M, Chauffert B, Martin F, Preud’Homme J-L: Brief report. Heavy-chain deposition disease. N Engl J Med 1993;329:1389–1423.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.