Des mesures simultanées des clearances urinaires du complexe 51Cr EDTA et du thiosulfate (valeur référentielle de la filtration glomérulaire) ont été effectuées chez 32 sujets atteints de néphropathies diverses. La clearance de l’EDTA est en moyenne de 91% celle du thiosulfate pour des valeurs normales de la filtration, mais de 99% pour des filtrations comprises entre 10 et 90 ml/min. Cette différence de comportement indépendante des variations de débit urinaire, est liée à la qualité des fonctions lénales; une équation est apportée, qui permet de corriger la valeur observée de la clearance de 51Cr EDTA au dessus de 40 ml/min. La variabilité intra-individuelle de chacune des deux clearances chez les sujets à filtration normale et la variabilité inter-individuelle du rapport des clearances chez les sujets normaux et les sujets pathologiques sont identiques. La variabilité intra-individuelle du rapport des clearances est faible et indépendante de la valeur de la filtration.

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