The reproducibility of the three parameters used in isotope renography (T/2 = time from the maximum until half the radioactivity over the kidney had been attained; t = time from injection until the maximum value was attained; and the maximum value) was studied in 41 patients by repeat tests in the same position. The influence of patient position to the same three parameters was also studied in 61 patients investigated in sitting and prone position. The values could be reproduced in 70–98% of the patients in the same position with a fairly wide definition of the concept reproducibility. Patient position was of no significance to the reproducibility. When changing from the sitting to the prone position, the maximum value decreased, while T/2 and t did not show any systematic alteration. A disparity between the function of the two kidneys was demonstrated with the same frequency in the sitting and prone position. This disparity between the two sides was more easily reproducible when X-ray examinations revealed unilateral renal disease. It is concluded that the reproducibility in isotope renography is not fully satisfactory. In the event of a disparity between the two sides the test should be repeated, and if there is a clinical or radiological suspicion of unilateral renal disease, one normal isotope renography should not be relied on, but the test repeated.

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