Processes which take place in a distinct part of the kidney, such as the proximal tubule, can be investigated in vitro. PAH accumulation, a proximal tubule function, was used to indicate the integrity of a transport system present in this region. Preincubation of rabbit renal cortical slices in Bence Jones protein depressed the ability of the slices to accumulate hippurate when compared to simultaneously run controls. Albumin, in contrast, did not appear to inhibit hippurate transport. Under the condition of these experiments basal oxygen consumption was not affected by Bence Jones protein or albumin; however, both endogenous gluconeogenesis and gluconeogenesis from glutamate were depressed by preincubation in Bence Jones protein. It is concluded that in vitro Bence Jones protein can alter certain proximal tubule activities such as hippurate transport and gluconeogenesis. These results may have a bearing on the reported association of proximal tubule dysfunction with Bence Jones proteinuria.

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