Au cours d’une épreuve de Howard, on a étudié chez quatre hypertendus la concentration de divers indicateurs dans des échantillons successifs d’urine pendant la période qui suit leur brusque injection intraveineuse simultanée. L’ordre d’apparition est le suivant: 42K, acide urique 2 14C, P.A.H., inuline (tableau I, fig. 1). L’acide urique 2 14C apparait très près du P.A.H. dans la plupart des expériences. Il est conclu que chez l’homme le tube proximal est perméable à l’acide urique. Les limites de cette technique ont été discutées.

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