Abstract
To determine whether chronic saline ingestion is required for protection against acute renal failure, we examined the effect of the time at which saline was offered. Water-drinking rats developed severe azotemia (BUN 115 ± 6mg/dl; 41 ± 2 mmol/l) 24 h after 50% glycerol i.m. Chronic saline ingestion for 30 days conferred protection only if continued after the insult (BUN 49 ± 4 mg/dl; 18· ± 1 mmol/l; p < 0.0l) but not if saline was withdrawn (BUN 110 ± 8 mg/dl; 38 ± 3 mmol/l). Moreover, saline offered only after the insult conferred equivalent protection (BUN 57 ± 6 mg/dl; 21 ± 2 mmol/l). Fluid intake, arterial blood pressure and plasma volume were better sustained in saline-drinking rats.
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© 1982 S. Karger AG, Basel
1982
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