A method is presented for determining effective renal plasma flow in man utilizing a single injection of Hippuran 131I and two plasma samples. The radioactivity remaining in the plasma at 20 and 30 min after injection of the dose is plotted on semi-logarithmic graph paper. The clearance is calculated from the slope of a line connecting these points and the time zero intercept [clearance Dose/Zero intercept × λ (slope)] The method has proved accurate and correlates closely with PAH clearances (correlation coefficient = 0.90, regression coefficient = 1.02). This simplified single injection clearance is recommended for use in clinical situations where it appears desirable to know the effective renal plasma flow in determining the status of the patient’s renal function. It is also of use in clinical studies where it would be unfeasible to perform standard clearances.

This content is only available via PDF.
© 1966 S. Karger AG, Basel
1966
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.