Nephrotoxic antibody rapidly fixes to glomerular basement membrane following systemic injection and immediately initiates histopathologic alterations. We studied the functional changes induced by nephrotoxic serum (NTS) in dogs starting 20 min after injection using three different protocols. By this time the GFR, UNaV and FENa had decreased in each study. Volume expansion resulted in a significantly smaller absolute increase in FENa than in the pre-injection control study (1.1 vs. 2.8%, p < 0.005), while maximum tubular secretion of PAH (TmPAH) and reabsorption of glucose (Tm glucose) stayed constant following NTS; thus, TmPAH/ GFR and Tm glucose/GFR increased significantly. These studies demonstrate that glomerular function is rapidly affected by NTS while absolute tubular function is relatively well maintained. Since histologic and functional changes occurred simultaneously, it seems likely that the functional changes were the direct consequence of the pathologic alterations.

Keywords:
Acute nephrotoxic nephritis, Kidney function, Maximum PAH secretion, Maximum glucose reabsorption
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© 1977 S. Karger AG, Basel
1977
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