1.
Sandner
P
.
From molecules to patients: exploring the therapeutic role of soluble guanylate cyclase stimulators
.
Biol Chem
.
2018 Jun 27
;
399
(
7
):
679
90
.
2.
Gao
Y
,
Raj
JU
.
Regulation of the pulmonary circulation in the fetus and newborn
.
Physiol Rev
.
2010 Oct
;
90
(
4
):
1291
335
.
3.
Tsai
EJ
,
Kass
DA
.
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
.
Pharmacol Ther
.
2009 Jun
;
122
(
3
):
216
38
.
4.
Friebe
A
,
Koesling
D
.
The function of NO-sensitive guanylyl cyclase: what we can learn from genetic mouse models
.
Nitric Oxide
.
2009 Nov–Dec
;
21
(
3–4
):
149
56
.
5.
Krishnan
SM
,
Kraehling
JR
,
Eitner
F
,
Benardeau
A
,
Sandner
P
.
The impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) signaling cascade on kidney health and disease: a preclinical perspective
.
Int J Mol Sci
.
2018 Jun 9
;
19
(
6
):
1712
.
6.
Terada
Y
,
Tomita
K
,
Nonoguchi
H
,
Marumo
F
.
Polymerase chain reaction localization of constitutive nitric oxide synthase and soluble guanylate cyclase messenger RNAs in microdissected rat nephron segments
.
J Clin Invest
.
1992 Aug
;
90
(
2
):
659
65
.
7.
Stasch
JP
,
Schlossmann
J
,
Hocher
B
.
Renal effects of soluble guanylate cyclase stimulators and activators: a review of the preclinical evidence
.
Curr Opin Pharmacol
.
2015 Apr
;
21
:
95
104
.
8.
Modlinger
PS
,
Wilcox
CS
,
Aslam
S
.
Nitric oxide, oxidative stress, and progression of chronic renal failure
.
Semin Nephrol
.
2004 Jul
;
24
(
4
):
354
65
.
9.
Nossaman
B
,
Pankey
E
,
Kadowitz
P
.
Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications
.
Crit Care Res Pract
.
2012
;
2012
:
290805
.
10.
Prawez
S
,
Ahanger
AA
,
Singh
TU
,
Mishra
SK
,
Sarkar
SN
,
Kumar
D
.
BAY 41-2272 treatment improves acetylcholine-induced aortic relaxation in L-NAME hypertensive rats
.
Int J Angiol
.
2016 Dec
;
25
(
4
):
235
40
.
11.
Stasch
JP
,
Dembowsky
K
,
Perzborn
E
,
Stahl
E
,
Schramm
M
.
Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies
.
Br J Pharmacol
.
2002 Jan
;
135
(
2
):
344
55
.
12.
Geschka
S
,
Kretschmer
A
,
Sharkovska
Y
,
Evgenov
OV
,
Lawrenz
B
,
Hucke
A
,
.
Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats
.
PLoS One
.
2011
;
6
(
7
):
e21853
.
13.
Schinner
E
,
Wetzl
V
,
Schramm
A
,
Kees
F
,
Sandner
P
,
Stasch
JP
,
.
Inhibition of the TGFβ signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis
.
FEBS Open Bio
.
2017 Apr
;
7
(
4
):
550
61
.
14.
Sharkovska
Y
,
Kalk
P
,
Lawrenz
B
,
Godes
M
,
Hoffmann
LS
,
Wellkisch
K
,
.
Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models
.
J Hypertens
.
2010 Aug
;
28
(
8
):
1666
75
.
15.
Follmann
M
,
Ackerstaff
J
,
Redlich
G
,
Wunder
F
,
Lang
D
,
Kern
A
,
.
Discovery of the soluble guanylate cyclase stimulator vericiguat (BAY 1021189) for the treatment of chronic heart failure
.
J Med Chem
.
2017 Jun 22
;
60
(
12
):
5146
61
.
16.
Tobin
JV
,
Zimmer
DP
,
Shea
C
,
Germano
P
,
Bernier
SG
,
Liu
G
,
.
Pharmacological characterization of IW-1973, a novel soluble guanylate cyclase stimulator with extensive tissue distribution, antihypertensive, anti-inflammatory, and antifibrotic effects in preclinical models of disease
.
J Pharmacol Exp Ther
.
2018 Jun
;
365
(
3
):
664
75
.
17.
Peters
H
,
Wang
Y
,
Loof
T
,
Martini
S
,
Kron
S
,
Kramer
S
,
.
Expression and activity of soluble guanylate cyclase in injury and repair of anti-thy1 glomerulonephritis
.
Kidney Int
.
2004 Dec
;
66
(
6
):
2224
36
.
18.
Stasch
JP
,
Schmidt
PM
,
Nedvetsky
PI
,
Nedvetskaya
TY
,
Hs
AK
,
Meurer
S
,
.
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
.
J Clin Invest
.
2006 Sep
;
116
(
9
):
2552
61
.
19.
Roelofs
JJ
,
Vogt
L
.
Diabetic nephropathy: pathophysiology and clinical aspects.
Springer
;
2018
.
20.
Zimmer
DP
,
Shea
CM
,
Tobin
JV
,
Tchernychev
B
,
Germano
P
,
Sykes
K
,
.
Olinciguat, an oral sGC stimulator, exhibits diverse pharmacology across preclinical models of cardiovascular, metabolic, renal, and inflammatory disease
.
Front Pharmacol
.
2020
;
11
:
419
.
21.
Straub
A
,
Benet-Buckholz
J
,
Frode
R
,
Kern
A
,
Kohlsdorfer
C
,
Schmitt
P
,
.
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase
.
Bioorg Med Chem
.
2002 Jun
;
10
(
6
):
1711
7
.
22.
Hahn
MG
,
Lampe
T
,
El Sheikh
S
,
Griebenow
N
,
Woltering
E
,
Schlemmer
KH
,
.
Discovery of the soluble guanylate cyclase activator runcaciguat (BAY 1101042)
.
J Med Chem
.
2021 May 13
;
64
(
9
):
5323
44
.
23.
Akash
MS
,
Rehman
K
,
Chen
S
.
Goto-Kakizaki rats: its suitability as non-obese diabetic animal model for spontaneous type 2 diabetes mellitus
.
Curr Diabetes Rev
.
2013 Sep
;
9
(
5
):
387
96
.
24.
Vallon
V
,
Kirschenmann
D
,
Wead
LM
,
Lortie
MJ
,
Satriano
J
,
Blantz
RC
,
.
Effect of chronic salt loading on kidney function in early and established diabetes mellitus in rats
.
J Lab Clin Med
.
1997 Jul
;
130
(
1
):
76
82
.
25.
Birk
C
,
Richter
K
,
Huang
DY
,
Piesch
C
,
Luippold
G
,
Vallon
V
.
The salt paradox of the early diabetic kidney is independent of renal innervation
.
Kidney Blood Press Res
.
2003
;
26
(
5–6
):
344
50
.
26.
Vallon
V
,
Osswald
H
.
Dipyridamole prevents diabetes-induced alterations of kidney function in rats
.
Naunyn Schmiedebergs Arch Pharmacol
.
1994 Feb
;
349
(
2
):
217
22
.
27.
Vallon
V
,
Richter
K
,
Blantz
RC
,
Thomson
S
,
Osswald
H
.
Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption
.
J Am Soc Nephrol
.
1999 Dec
;
10
(
12
):
2569
76
.
28.
Vallon
V
.
Micropuncturing the nephron
.
Pflugers Arch
.
2009 May
;
458
(
1
):
189
201
.
29.
Thomson
SC
,
Rieg
T
,
Miracle
C
,
Mansoury
H
,
Whaley
J
,
Vallon
V
,
.
Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat
.
Am J Physiol Regul Integr Comp Physiol
.
2012 Jan
;
302
(
1
):
R75
83
.
30.
Fu
Y
,
Gerasimova
M
,
Batz
F
,
Kuczkowski
A
,
Alam
Y
,
Sanders
PW
,
.
PPARγ agonist-induced fluid retention depends on αENaC expression in connecting tubules
.
Nephron
.
2015
;
129
(
1
):
68
74
.
31.
Fu
Y
,
Breljak
D
,
Onishi
A
,
Batz
F
,
Patel
R
,
Huang
W
,
.
Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin
.
Am J Physiol Renal Physiol
.
2018 Aug
;
315
(
2
):
F386
94
.
32.
Novikov
A
,
Fu
Y
,
Huang
W
,
Freeman
B
,
Patel
R
,
van Ginkel
C
,
.
SGLT2 inhibition and renal urate excretion: role of luminal glucose, GLUT9, and URAT1
.
Am J Physiol Renal Physiol
.
2019 Jan
;
316
(
1
):
F173
85
.
33.
Yamamoto
T
,
Noiri
E
,
Ono
Y
,
Doi
K
,
Negishi
K
,
Kamijo
A
,
.
Renal L-type fatty acid: binding protein in acute ischemic injury
.
J Am Soc Nephrol
.
2007 Nov
;
18
(
11
):
2894
902
.
34.
Fuhrich
DG
,
Lessey
BA
,
Savaris
RF
.
Comparison of HSCORE assessment of endometrial beta3 integrin subunit expression with digital HSCORE using computerized image analysis (ImageJ)
.
Anal Quant Cytopathol Histpathol
.
2013 Aug
;
35
(
4
):
210
6
.
35.
Vallon
V
,
Komers
R
.
Pathophysiology of the diabetic kidney
.
Compr Physiol
.
2011
;
1
(
3
):
1175
232
.
36.
Vallon
V
,
Thomson
SC
.
The tubular hypothesis of nephron filtration and diabetic kidney disease
.
Nat Rev Nephrol
.
2020 Jun
;
16
(
6
):
317
36
.
37.
Carrisoza-Gaytan
R
,
Ray
EC
,
Flores
D
,
Marciszyn
AL
,
Wu
P
,
Liu
L
,
.
Intercalated cell BKα subunit is required for flow-induced K+ secretion
.
JCI Insight
.
2020 Apr 7
;
5
(
8
):
130553
.
38.
Loutzenhiser
R
,
Hayashi
K
,
Epstein
M
.
Atrial natriuretic peptide reverses afferent arteriolar vasoconstriction and potentiates efferent arteriolar vasoconstriction in the isolated perfused rat kidney
.
J Pharmacol Exp Ther
.
1988 Aug
;
246
(
2
):
522
8
.
39.
Veldkamp
PJ
,
Carmines
PK
,
Inscho
EW
,
Navar
LG
.
Direct evaluation of the microvascular actions of ANP in juxtamedullary nephrons
.
Am J Physiol
.
1988 Mar
;
254
(
3 Pt 2
):
F440
4
.
40.
Kimura
K
,
Hirata
Y
,
Nanba
S
,
Tojo
A
,
Matsuoka
H
,
Sugimoto
T
.
Effects of atrial natriuretic peptide on renal arterioles: morphometric analysis using microvascular casts
.
Am J Physiol
.
1990 Dec
;
259
(
6 Pt 2
):
F936
44
.
41.
Thomson
SC
,
Deng
A
.
Cyclic GMP mediates influence of macula densa nitric oxide over tubuloglomerular feedback
.
Kidney Blood Press Res
.
2003 2003
;
26
(
1
):
10
8
.
42.
Lanese
DM
,
Yuan
BH
,
Falk
SA
,
Conger
JD
.
Effects of atriopeptin III on isolated rat afferent and efferent arterioles
.
Am J Physiol
.
1991 Dec
;
261
(
6 Pt 2
):
F1102
9
.
43.
Brenner
BM
,
Ballermann
BJ
,
Gunning
ME
,
Zeidel
ML
.
Diverse biological actions of atrial natriuretic peptide
.
Physiol Rev
.
1990 Jul
;
70
(
3
):
665
99
.
44.
Zatz
R
,
de Nucci
G
.
Effects of acute nitric oxide inhibition on rat glomerular microcirculation
.
Am J Physiol
.
1991 Aug
;
261
(
2 Pt 2
):
F360
3
.
45.
Deng
A
,
Baylis
C
.
Locally produced EDRF controls preglomerular resistance and ultrafiltration coefficient
.
Am J Physiol
.
1993 Feb
;
264
(
2 Pt 2
):
F212
5
.
46.
Denton
KM
,
Anderson
WP
.
Intrarenal haemodynamic and glomerular responses to inhibition of nitric oxide formation in rabbits
.
J Physiol
.
1994 Feb 15
;
475
(
1
):
159
67
.
47.
Kramer
HJ
,
Horacek
V
,
Backer
A
,
Vaneckova
I
,
Heller
J
.
Relative roles of nitric oxide, prostanoids and angiotensin II in the regulation of canine glomerular hemodynamics. A micropuncture study
.
Kidney Blood Press Res
.
2004
;
27
(
1
):
10
7
.
48.
Blantz
RC
,
Konnen
KS
,
Tucker
BJ
.
Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat
.
J Clin Invest
.
1976 Feb
;
57
(
2
):
419
34
.
49.
Thomson
SC
,
Deng
A
,
Komine
N
,
Hammes
JS
,
Blantz
RC
,
Gabbai
FB
.
Early diabetes as a model for testing the regulation of juxtaglomerular NOS I
.
Am J Physiol Renal Physiol
.
2004 Oct
;
287
(
4
):
F732
8
.
50.
Hoffend
J
,
Cavarape
A
,
Endlich
K
,
Steinhausen
M
.
Influence of endothelium-derived relaxing factor on renal microvessels and pressure-dependent vasodilation
.
Am J Physiol
.
1993 Aug
;
265
(
2 Pt 2
):
F285
92
.
51.
Stehle
D
,
Xu
MZ
,
Schomber
T
,
Hahn
MG
,
Schweda
F
,
Feil
S
,
.
Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney
.
Br J Pharmacol
.
2022
;
179
(
11
):
2476
89
.
52.
Dautzenberg
M
,
Kahnert
A
,
Stasch
JP
,
Just
A
.
Role of soluble guanylate cyclase in renal hemodynamics and autoregulation in the rat
.
Am J Physiol Renal Physiol
.
2014 Nov 1
;
307
(
9
):
F1003
12
.
53.
Boerrigter
G
,
Costello-Boerrigter
LC
,
Cataliotti
A
,
Lapp
H
,
Stasch
JP
,
Burnett
JC
Jr
.
Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure
.
Hypertension
.
2007 May
;
49
(
5
):
1128
33
.
54.
Boerrigter
G
,
Costello-Boerrigter
LC
,
Cataliotti
A
,
Tsuruda
T
,
Harty
GJ
,
Lapp
H
,
.
Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure
.
Circulation
.
2003 Feb 11
;
107
(
5
):
686
9
.
55.
Majid
DS
,
Navar
LG
.
Nitric oxide in the control of renal hemodynamics and excretory function
.
Am J Hypertens
.
2001 Jun
;
14
(
6 Pt 2
):
74S
82S
.
56.
Yip
KP
.
Flash photolysis of caged nitric oxide inhibits proximal tubular fluid reabsorption in free-flow nephron
.
Am J Physiol Regul Integr Comp Physiol
.
2005 Aug
;
289
(
2
):
R620
6
.
57.
Potter
LR
,
Yoder
AR
,
Flora
DR
,
Antos
LK
,
Dickey
DM
.
Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications
.
Handb Exp Pharmacol
.
2009
(
191
):
341
66
.
58.
Garvin
JL
,
Herrera
M
,
Ortiz
PA
.
Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications
.
Annu Rev Physiol
.
2011
;
73
:
359
76
.
59.
Gao
Y
,
Stuart
D
,
Takahishi
T
,
Kohan
DE
.
Nephron-specific disruption of nitric oxide synthase 3 causes hypertension and impaired salt excretion
.
J Am Heart Assoc
.
2018 Jul 11
;
7
(
14
):
e009236
.
60.
Gonzalez-Vicente
A
,
Saez
F
,
Monzon
CM
,
Asirwatham
J
,
Garvin
JL
.
Thick ascending limb sodium transport in the pathogenesis of hypertension
.
Physiol Rev
.
2019 Jan 1
;
99
(
1
):
235
309
.
61.
Evans
RG
,
Majid
DSA
,
Eppel
GA
.
Mechanisms mediating pressure natriuresis: what we know and what we need to find out
.
Clin Exp Pharmacol Physiol
.
2005 May–Jun
;
32
(
5–6
):
400
9
.
62.
Shirai
A
,
Yamazaki
O
,
Horita
S
,
Nakamura
M
,
Satoh
N
,
Yamada
H
,
.
Angiotensin II dose-dependently stimulates human renal proximal tubule transport by the nitric oxide/guanosine 3’, 5’-cyclic monophosphate pathway
.
J Am Soc Nephrol
.
2014 Jul
;
25
(
7
):
1523
32
.
63.
Masuyama
H
,
Tsuruda
T
,
Sekita
Y
,
Hatakeyama
K
,
Imamura
T
,
Kato
J
,
.
Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart
.
Hypertens Res
.
2009 Jul
;
32
(
7
):
597
603
.
64.
Shea
CM
,
Price
GM
,
Liu
G
,
Sarno
R
,
Buys
ES
,
Currie
MG
,
.
Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure
.
Am J Physiol Renal Physiol
.
2020 Jan 1
;
318
(
1
):
F148
59
.
65.
Gheorghiade
M
,
Greene
SJ
,
Butler
J
,
Filippatos
G
,
Lam
CSP
,
Maggioni
AP
,
.
Effect of vericiguat, a soluble guanylate cyclase stimulator, on natriuretic peptide levels in patients with worsening chronic heart failure and reduced ejection fraction: the SOCRATES-REDUCED randomized trial
.
JAMA
.
2015 Dec 1
;
314
(
21
):
2251
62
.
66.
Benardeau
A
,
Kahnert
A
,
Schomber
T
,
Meyer
J
,
Pavkovic
M
,
Kretschmer
A
,
.
Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease
.
Naunyn Schmiedebergs Arch Pharmacol
.
2021 Dec
;
394
(
12
):
2363
79
.
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