The present studies compare clearance (K) for varying molecular weight (MW) solutes, Urea (U), Uric acid (Ua), BSP and B12 in hollow fiber kidneys (HFK) before and in reused hollow fiber kidneys (RHFK) after five hemodialyses. In 10 RHFK, 3 % H2O2 was perfused in the dialysate compartment to clear residual blood. Five RHFK were cleaned with water (W) alone. Fiber bundle volume (FBV) before each use was > 75 ml. RHFK with H2O2 appeared cleaner than with W. KU was 168 ± 6,134 ± 12, and 152 ± 10 ml/min; KUa was 144 ± 11, 89 ± 12, and 101 ± 6 ml/min; KBSP was 50 ± 7, 29 ± 7, and 42 ± 6 ml/min, and KB12 was 15 ± 2,7 ± 2 and 11 ± 2 ml/min with HFK before, RHFK with H2O2, and RHFK with W, respectively. The percentage decrease in K was greater for higher MW solutes. HFK cleaning with H2O2 before dialysis did not change solute transport markedly. The data suggest: (1) there is relatively greater decrease in middle molecule clearance than small molecule in RHFK, and (2) with comparable FBV, clearance is better (p < 0.01) for RHFK with W than RHFK with H2O2.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.