Prompted by the observation of marked alkaline phosphatase (AP) elevation in a patient with severe, bilateral pyelonephritis, a retrospective survey was undertaken of the records of patients hospitalized during 1970–1972 under the headings of pyelonephritis, papillary necrosis, hydro- and pyonephrosis. Patients with liver and bone disease or chronic renal failure were excluded. Out of 95 consecutive patients studied, 14 (14.7%) had substantial elevations of serum AP. The common feature of most cases was pyelonephritis with severe systemic manifestations; four patients had gram-negative bacteremia; two patients died of sepsis and uremia and the autopsy findings included bilateral, widespread, nonobstructive pyelonephritis with papillary necrosis in one case and multiple renal abscesses in the other. Eight patients had associated uni- or bilateral hydronephrosis. It is postulated that inflammatory tubular damage and extra- or intrarenal obstruction can result in release of AP into the circulation. Elevation of serum AP in pyelonephritis may be used as an indicator of extensive paren-chymal destruction and/or urinary tract obstruction.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.