... Advanced chronic renal failure Overexpression of Kv1.3 channels Tubulointerstitial fibrosis Kv1.3 channel inhibitor Benidipine In situ proliferation of leukocytes Proinflammatory cytokines Chronic renal failure (CRF) progresses relentlessly to end-stage renal disease. In advanced-stage CRF...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2011 Cyclosporine Uric acid Arteriolar hyalinosis Tubulointerstitial fibrosis NIH Cyclosporine...

... the fibrotic process. Methods: We performed unilateral ureteric obstruction (UUO) in wild-type C57BL/6, TLR2 knockout and TLR4 knockout mice. Gene expression of TGF-β and TNF-α within renal tissue was analysed by real-time PCR. Kidneys were also scored for the level of tubulointerstitial fibrosis, collagen...

...Taro Horino; Hiroyuki Ito; Takuya Yamaguchi; Mutsuo Furihata; Kozo Hashimoto Background: TGF-β 1 , which is one of the profibrogenic cytokines, is considered essential for both the tubulointerstitial fibrosis found in chronic kidney diseases and the repair of tissue damage in acute renal injury...

... stress and activate NF-ĸB to upregulate plasminogen activator inhibitor-1 in tubular cells. These mechanisms may promote tubulointerstitial fibrosis. The present study examined whether uremic toxins induce glomerular and tubulointerstitial damage in vivo. Two uremic toxins, hippuric acid (HA...

.... Conclusions: Taken together, it is suggested that fluvastatin may prevent tubulointerstitial fibrosis in a variety of progressive renal diseases by inhibiting proliferation of interstitial fibroblasts and their matrix synthesis. 7 10 2003 18 03 2004 17 11 2004 © 2004 S. Karger AG, Basel...

...), and renal active TGF-β1 concentration (at 14 days; NP = 5.72 ± 2.03 vs. LP = 2.96 ± 0.72; p < 0.01). We conclude that protein restriction may aid the attenuation of progression of tubulointerstitial fibrosis through the reduction in tubulointerstitial expression of TGF-β. Glomerulosclerosis...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hypoxia Tubulointerstitial fibrosis Extracellular matrix Tubular epithelia Interstitial fibroblasts Matrix metalloproteinases Tissue inhibitors of metalloproteinases Gene...

... by semiquantitative scores in a blind fashion. Corpuscular section area, intraglomerular and tubulointerstitial fibrosis were determined by digital image analysis with a specific software (Fibrosis HR ® ) on syrium red-stained renal sections. Trandolapril markedly increased the survival ratio that after 6 months...