... EGP-2 molecule EpCAM molecule Kidney development Cell adhesion molecules Transgenic mouse Epithelial cell adhesion molecule (EpCAM), also referred to as epithelial glycoprotein-2 (EGP-2, CD326), is a transmembrane cell surface adhesion molecule of 38 kDa which was originallyidentified...

... nephropathy Diabetic glomerulopathy Transgenic mouse TGF-β1 Type IV collagen Diabetic nephropathy is a leading cause of end-stage renal disease and accounts for disabilities and high mortality rates in patients with diabetes [ 1 ]. The mechanisms by which hyperglycemia causes glomerular...

..., instructions or products referred to in the content or advertisements. Water transport Aquaporins Urinary concentrating mechanism Transgenic mouse Water transport across kidney tubular epithelia and microvascular endothelia plays a key role in kidney function. The proximal tubule reabsorbs...

...Peter K. Stricklett; Raoul D. Nelson; Donald E. Kohan The aquaporin-2 promoter has been used to drive Cre recombinase expression in order to achieve renal collecting duct principal cell specific gene deletion. This technique requires two lines of mice: one transgenic mouse line containing a cell...

... allow a podocyte-specific expression of a molecule of interest in kidney. Green fluorescence protein Transgenic mouse Podocyte CMV enhancer β-Actin promoter CX promoter We demonstrated that CX promoter selectively activated the transcription of GFP in podocytes as well as in skeletal...