... of COX-2 in podocytes during the course of self-limited glomerular injury, we administered puromycin nucleoside (PAN) on day 1 (15 mg/100 g BW) and day 3 (30 mg/100 g BW) to wild-type and transgenic mice with podocyte-specific COX-2 expression driven by a nephrin promoter. An additional group received...

... transgenic mice expressing enhanced green fluorescent protein under the control of the ORG promoter. Results: ORG mRNA was shown to be expressed in mouse kidneys and in a variety of other tissues. Fusion constructs transfected in opossum kidney cells demonstrated integrity of the open reading frame...

... glycoprotein 130. We investigated the in vivo antinephritic effect of ATRA on IL-6 transgenic mice which had developed mesangial proliferative glomerulonephritis (PGN) as well as its in vitro inhibitory effect on the proliferation of rat mesangial cells. In vivo experiments on IL-6 transgenic mice showed...

... Thrombospondin-1 Transgenic mice Glomerulonephritis Glomerular injury in most forms of glomerulonephritis (GN) is associated with leukocyte infiltration, fibrin and platelet deposition, proliferation of intrinsic cells, mesangial sclerosis, and glomerular basement membrane (GBM) thickening [ 1, 2, 3...

..., especially in transgenic mice. Simple murine models displaying the clinical features of other human renal diseases such as IgA nephropathy, membranous glomerulonephritis, and renal vasculitis are still lacking. Mouse strains that spontaneously develop distinct renal pathologies similar to lupus nephritis...

...A. Vandewalle Targeted oncogenesis in transgenic mice, where an oncogene is placed under the control of the regulatory sequences of a cell-specific gene, has been used to derive several new types of differentiated nonepithelial and epithelial cell lines. This review summarizes the properties...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Gene targeting Transgenic mice Kidney Tissue-specific gene targeting Cre-loxP system Gene targeting to create loss of gene function (knockout) relies...