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1-3 of 3
Keywords: Sp1
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Journal Articles
Subject Area:
Nephrology
Hassan Khammas, Timothy Bowen, John David Williams, Aled Owain Phillips, Robert Steadman, John Martin
Journal:
Nephron Experimental Nephrology
Nephron Experimental Nephrology (2011) 118 (2): e27–e38.
Published Online: 23 December 2010
... assembled to examine the transcription start site and characterise the promoter region of this gene. Results: A 145-bp proximal promoter construct showed full activity in unstimulated cells. Analysis of this region identified three potential Sp1-binding sites. Electromobility and supershift assays confirmed...
Journal Articles
Subject Area:
Nephrology
Journal:
Nephron Experimental Nephrology
Nephron Experimental Nephrology (2007) 107 (2): e57–e64.
Published Online: 20 September 2007
... cysts in kidneys. In previous studies, the functional regulatory sequences of Pkd1 promoter region were detected by the use of comparative genome analysis. Methods: To investigate the transcriptional regulation of the Pkd1 gene, the Pkd1 promoter was isolated. This promoter contains three Sp1-binding...
Journal Articles
Subject Area:
Nephrology
Yutaka Kanamaru, Atsuhito Nakao, Yuichi Tanaka, Yutaka Inagaki, Hiroko Ushio, Isao Shirato, Satoshi Horikoshi, Ko Okumura, Hideoki Ogawa, Yasuhiko Tomino
Journal:
Nephron Experimental Nephrology
Nephron Experimental Nephrology (2003) 95 (1): e36–e42.
Published Online: 17 November 2004
... and functional cooperation of Smad proteins and Sp1. A transcriptional coactivator, p300, is also suggested to play an important role in TGF-β1/Smad signal transduction. However, the role of p300 in TGF-β1/Smad-pathway-mediated transcriptional activation of the COL1A2 gene in mesangial cells is still obscure...
