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Keywords: Proteinuria
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Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2012) 121 (1-2): e23–e37.
Published Online: 25 October 2012
... nephropathy (passive Heymann nephritis model) and mice with experimental FSGS (anti-glomerular antibody model) following the onset of proteinuria. Immunohistochemistry staining of PAX2 (parietal epithelial cell marker), WT-1 (podocyte cell marker), and Ki-67 (proliferation marker) were performed on kidney...
Journal Articles
Nephron Experimental Nephrology (2012) 120 (2): e69–e80.
Published Online: 30 March 2012
... progressive worsening of podocyte and glomerular damage in both male and female Rab3A KO. Though glomerular lesions, reminiscent of human diabetic nephropathy, were more severe in male mice, overt proteinuria and renal damage were also evident in female mice. The in vitro analysis of Rab3A WT and KO podocytes...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2011) 119 (3): e58–e66.
Published Online: 18 August 2011
...Jeanette Eyre; James O. Burton; Moin A. Saleem; Peter W. Mathieson; Peter S. Topham; Nigel J. Brunskill Background/Aims: Proteinuria is associated with cardiovascular and chronic kidney disease. Microparticles (MPs) are bioactive vesicles shed from activated cells and also linked to cardiovascular...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2011) 117 (1): e9–e20.
Published Online: 04 August 2010
... CTGF expression was mainly localized in podocytes. Accordingly, elevation of urinary, plasma, and tissue CTGF in UNX-SHR coincided and correlated with proteinuria, glomerulosclerosis, and tubulointerstitial fibrosis. Thirty-two weeks after uninephrectomy, mean glomerular CTGF mRNA expression...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2010) 116 (2): e32–e41.
Published Online: 29 June 2010
... Protein overload Kidney failure Proteinuria Cytokines Plasma cell dyscrasias The kidney is the major site of metabolism of light-chain (LC) proteins. Filtered LC proteins are endocytosed by the proximal tubule cells via the tandem megalin/cubilin receptors, and catabolized by lysosomal enzymes...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2010) 116 (1): e3–e10.
Published Online: 21 May 2010
... ameliorates proteinuria in puromycin aminonucleoside (PAN) nephropathy, the effect of MZR on podocytes has not been clarified. In this study, we determined whether MZR directly prevents PAN-induced podocyte injury. Methods: Rats were intravenously injected once on day 0 with 100 mg/kg of PAN and received...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2010) 114 (2): e39–e47.
Published Online: 03 November 2009
...Masaru Motojima; Taiji Matsusaka; Valentina Kon; Iekuni Ichikawa Background: Composition of nonselective proteinuria includes several endogenous ligands of Toll-like receptors (TLRs) not normally present in Bowman’s space, thus raising the possibility that TLRs are involved in proteinuria-mediated...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2009) 113 (2): e45–e56.
Published Online: 10 July 2009
... hybridization Proteinuria Puromycin aminonucleoside nephrosis Western blotting A chemokine fractalkine (FKN/CX3CL1) is the only one member of the CX 3 C chemokine family characterized by its unique structure of N-terminal cysteine residues. The extracellular CX 3 C chemokine domain is attached...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2009) 112 (2): e43–e58.
Published Online: 18 April 2009
... by subepithelial immune deposits, podocyte foot processes effacement and massive proteinuria beginning 4 days following disease induction. Although single genes involved in PHN have been studied, no whole genome-wide expression analysis of kidney tissue has been performed. Methods: Microarray analysis...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2009) 111 (4): e92–e102.
Published Online: 17 March 2009
... to day 28. The reduction in VEGF and phosphorylated nephrin was not a result of podocyte loss. The intervention of prednisone and lisinopril evidently reduced proteinuria, effectively attenuated the severe lesions of podocyte foot processes, and restored the reduction in VEGF and nephrin phosphorylation...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2009) 111 (2): e31–e41.
Published Online: 13 January 2009
... and immunohistochemical staining. Results: Treated animals showed reduction in serum AGEs (p < 0.01), proteinuria (p < 0.01) and systolic blood pressure (p < 0.01). GSPE reduced the expression of RAGE (p < 0.01) and CTGF (p < 0.01) in the kidney, which were contributing to reversal of extracellular matrix...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2008) 110 (3): e73–e81.
Published Online: 27 October 2008
... that disturbances of podocyte biology contribute to proteinuria in women with preeclampsia (PE). Methods: A human podocyte cell line was stimulated with serum from women with PE (patients) and healthy pregnant women (controls); the main changes in 3 important podocyte proteins: podocin, CD2AP and actin were...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2008) 110 (2): e67–e71.
Published Online: 13 October 2008
...Richard J. Baines; Nigel J. Brunskill Proteinuria is associated with progressive chronic kidney disease and poor cardiovascular outcomes. Exposure of proximal tubular epithelial cells to excess proteins leads to the development of proteinuric nephropathy with tubular atrophy, interstitial...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2008) 108 (3): e57–e68.
Published Online: 04 April 2008
...Shigetaka Yoshida; Miki Nagase; Shigeru Shibata; Toshiro Fujita Background: Proteinuria is a well-established exacerbating factor in chronic kidney disease. Although the mechanisms of albumin-induced tubulointerstitial damage have been extensively studied, the influence of proteinuria on podocytes...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2007) 107 (3): e87–e94.
Published Online: 21 September 2007
...Young-Il Jo; Huifang Cheng; Suwan Wang; Gilbert W. Moeckel; Raymond C. Harris Previous studies from our own group and others have demonstrated that cyclooxygenase-2 (COX-2) inhibitors could reduce proteinuria in some experimental models of progressive renal disease. To investigate a possible role...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2006) 104 (4): e158–e168.
Published Online: 11 August 2006
... injury only when combined with ACE inhibitor. We investigated whether in a two-kidney diabetic model the time at which treatment started predicted the response to TGFβ antagonist. Methods: 27 weeks after streptozotocin injection, animals had mild proteinuria and were randomized to receive irrelevant...