... concentrations of glucose as the osmotic agent. Glucose is widely used as the osmotic agent for PDFs because it is effective, inexpensive, easily metabolized, and a natural source of energy. However, long-term exposure to high glucose (HG) concentrations may result in oxidative stress, which damages PMCs and may...

..., are central to the pathogenesis of CKD. The aim here was to use an in vitro model to investigate the separate and cumulative effects of oxidative stress, mitochondrial dysfunction and cell senescence in promoting loss of renal mass. Methods: Human kidney tubular epithelial cells (HK2) were treated...

...: Telmisartan was administered at a dose of 5 mg/kg/day for 3 weeks to db/db (diabetic) and db/m (control) mice. Urinary albumin excretion, renal histology, and the gene expression of oxidative stress and inflammatory markers in renal tissue were determined. To evaluate the effects of telmisartan on reactive...

...Hye Eun Yoon; Sun Woo Lim; Shang Guo Piao; Ji-Hyun Song; Jin Kim; Chul Woo Yang Background: We recently reported that long-term cyclosporine (CsA)-induced oxidative stress is associated with decreased expression of klotho , an anti-aging gene. This study evaluated whether the antioxidant effect...

... increased caspase-3 activity and led to a higher number of apoptotic cells that were prevented by tempol and the PARP-1 inhibitor. Conclusion: In DM, tempol reduces albuminuria associated with reduction of podocyte apoptosis and decreasing oxidative stress via PARP signaling. Western blot assay [ 7...

..., extracellular matrix accumulation, and angiogenesis were evaluated by immunostaining for ED-1, fibronectin, and CD-31, respectively. To observe oxidative stress in the tissue, 4-hydroxy-2-noneal (HNE) accumulation and plasma levels of superoxide dismutase (SOD) activity were detected. As a candidate...

...Bin Sun; Chao Lu; Guo-Ping Zhou; Chang-Ying Xing Background: Oxidative stress is an important inducer of cell apoptosis and plays a key role in the development of renal inflammation. The prostate apoptosis response factor-4 (Par-4) gene was originally identified in prostate cells undergoing...

...Yasmir Quiroz; Atilio Ferrebuz; Nosratola D. Vaziri; Bernardo Rodriguez-Iturbe Oxidative stress and inflammation play a major role in the progression of renal damage and antioxidants are potentially useful therapeutic options in chronic renal disease. We investigated if treatment with tempol...

...Reiko Inagi The endoplasmic reticulum (ER) plays an important role in the maintenance of protein homeostasis through its control of the concentration, conformation, folding, and trafficking of client proteins. Disturbances such as hypoxia, glucose depletion, and oxidative stress may lead to ER...

...Shin-ichiro Yoshida; Tatsuo Hashimoto; Minoru Kihara; Nozomi Imai; Hiroaki Yasuzaki; Kouichirou Nomura; Yoshihiro Kiuchi; Kouichi Tamura; Tomoaki Ishigami; Nobuhito Hirawa; Yoshiyuki Toya; Hitoshi Kitamura; Satoshi Umemura Backgrounds/Aims: It has been reported that urinary oxidative stress markers...

...Jay L. Koyner; Roshan Sher Ali; Patrick T. Murray Over the past several years, advances in our understanding of the pathogenesis of acute kidney injury (AKI) have demonstrated the role of oxidant stress and reactive oxygen metabolites (ROM) in the development of AKI in a variety of clinical...

... by increased carbonyl stress and elevated methylglyoxal (MGO) levels. MGO causes oxidative stress and intracellular calcium accumulation. In the present study, we investigated whether the effect of MGO-induced calcium accumulation in RBCs develops through increased oxidative stress. Furthermore, we studied...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2007 Diabetic nephropathy Genetic susceptibility Gene polymorphism Oxidative stress Diabetic nephropathy is arguably the most serious of the microvascular diabetic...

...Madhu Bhaskaran; Neetu Radhakrishnan; Hitesh Patni; Priyanka Singh; Ahmad N. Chaudhary; Pravin C. Singhal Dialysis membranes have been reported to induce monocyte apoptosis. We studied the role of oxidative stress in the induction of dialysis membrane-induced monocyte apoptosis. Superoxide...

... and utilisation of genetically modified (knockout and transgenic) mice on a C57BL/6 background has provided important insights into the roles of oxidative stress, advanced glycation end products, inflammation and profibrotic mechanisms in the development of type 1 and type 2 diabetic nephropathy. Conclusion...

... (mIMCD3) cell line for the first time, and in the present study we explored the physiological relevance of the regulation of klotho expression in the presence of oxidant stress injury. Methods: Klotho expression was analyzed by real-time PCR, Western blot, and immuocytochemical staining during exposure...

...Bin Zhu; Hanchao Shen; Junfu Zhou; Feili Lin; Ying Hu Aims: To study the effects of simvastatin on oxidative stress in rats with early stage diabetic nephropathy. Methods: 60 male Sprague-Dawley rats were divided into three groups: control group (CN), streptozotocin (STZ)-induced diabetic rats...

.... Iron plays an important part in inflammatory damage since it supplies cytotoxic hydroxyl radicals. The aim of the present study was to examine the direct effects of iron on TGF-β 1 production and the expression of 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative stress, by human renal...

.... 2004 Ischemic preconditioning Subtractive hybridization Hypoxia Oxidative stress Renal failure Although IPC has been observed in renal tissue, the mechanisms involved in renal cell protection are almost entirely unknown. In the present paper, we were particularly interested in exploring...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2004 Diabetes Diabetic kidney Oxidative stress Lipid peroxidation Antioxidant enzymes Vitamin C Vitamin E...