... and an increase in CD44+ PECs was associated with reduced expression of synaptopodin and podocin in diseased glomeruli. Furthermore, immunofluorescence staining demonstrated co-expression with osteopontin, a CD44 ligand that plays a significant role in the progression of glomerulosclerosis, thereby suggesting...

...Ashwani Khanna The mechanism of immunosuppression-linked nephrotoxicity in organ transplantation remains to be solved. Expression of osteopontin (OPN), a multifunctional secreted glycoprotein, has been associated with various forms of renal injuries. In this study, using in vitro and in vivo models...

...Dierk J. Hampel; Christine Sansome; Victor I. Romanov; Aaron J. Kowalski; David T. Denhardt; Michael S. Goligorsky Osteopontin (OPN), a secretory RGD-containing phosphoprotein, is induced in acute renal injury where it plays a renoprotective role. To investigate in depth the mode of OPN secretion...

...Seitaro Iguchi; Shinichi Nishi; Mika Ikegame; Kazuto Hoshi; Tatsuya Yoshizawa; Hiroyuki Kawashima; Masaaki Arakawa; Hidehiro Ozawa; Fumitake Gejyo Osteopontin (OPN) is considered as a key protein in cell regeneration. OPN is thought to have many functions in cell-cell binding and cell-matrix...

...Zemin Cao; Alison Cox; Fabrice Bonnet Osteopontin is an extracellular matrix protein that is upregulated in renal injury. The aim of this study was to explore the renal expression of osteopontin in a model of progressive renal injury following subtotal nephrectomy (STNx) in rats and the effects...

...Susan R. Rittling; David T. Denhardt Osteopontin (OPN) is a soluble secreted phosphoprotein that binds with high affinity to several different integrins. While numerous activities have been ascribed to OPN in vitro, and several in vivo functions have been suggested for the molecule, including much...