... hypothesized that uric acid (UA), which can induce endothelial dysfunction in vitro and in vivo, might also alter mitochondrial function. Methods: Human aortic endothelial cells were exposed to soluble UA and measurements of oxidative stress, nitric oxide, mitochondrial density, ATP production, aconitase-2...

... appears to be an important mechanism in the renal disease process, however little is known about the mechanisms involved. Therefore we examined the potential role of nitric oxide (NO) in the regulation of MMP-9 and TIMP-1 by tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) using the human...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2008 Acute renal failure Vasodilatation Nitric oxide Apoptosis Glomerulus Tubule Afferent arteriole Efferent arteriole Glomerular filtration rate Severe...

... factor, change in arterial pressure and activation of sympathetic nerves, as well as direct effects on the kidney [ 16 ]. We and others have shown that opioids also induce nitric oxide synthase (NOS), hemoxygenase-1 (HO-1) and cyclooxygenase-2 (COX-2) [ 17, 18, 19 ] which are potent vasodilators. Further...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2004 Nitric oxide Superoxide Redox signaling Gene expression Inflammation...

...Mari Hoshiyama; Bing Li; Jian Yao; Takashi Harada; Tetsuo Morioka; Takashi Oite Background: Hyperglycemia directly contributes to the development of diabetic nephropathy. Nitric oxide (NO), a potent endothelium-derived vasodilator, has been suggested to participate in the regulation of renal blood...

...Sophie Vandermeersch; Vadislav Stefanovic; Annette Hus-Citharel; Raymond Ardaillou; Jean-Claude Dussaule; Dominique Chansel Chronic inhibition of nitric oxide synthase promotes renin-dependent hypertension and renal injury. The present study examines how renal angiotensin II receptors are expressed...

... ticlopidine lowers the blood pressure in hemodialysis patients is unclear. To elucidate the mechanism of the action of this drug, we investigated cytokine-stimulated nitric oxide (NO) metabolism by ticlopidine in cultured rat vascular smooth muscle cells (VSMC). Methods: Nitrite, a stable metabolite...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Vasa recta Microcirculation Oxygen Nitric oxide Kidney Vasopressin, in our hands, compared to angiotensin and endothelins is a mild DVR vasoconstrictor [ 13 ]. Experiments...

... and the potential role of nitric oxide (NO) and endothelin in these changes. In anesthetized rats endotoxin infusion [lipopolysaccharide (LPS), Escherichia coli serotype 0127:B8; 10 mg/kg/h] resulted in hypotension and a transient enhancement of renal blood flow, with cortical vasodilation and a loss of outer...

... generation for high concentrations are present at inflammatory sites. Regulation occurs through cytokines, substrate competition and products of nitric oxide (NO) metabolism. The functions of arginases at inflammatory sites are unknown, but may include regulation of apoptosis and NO production and generation...

...Prabal K. Chatterjee; Gabrielle M. Hawksworth; James S. McLay Although the importance of the human kidney in a variety of disease states is well recognised, the exact mechanisms involved remain unclear. Animal disease models suggest that while high local concentrations of nitric oxide (NO) may play...

...Karen Mosley; Simon N. Waddington; Hatim Ebrahim; Terence Cook; Victoria Cattell Thy 1 glomerulonephritis (GN) is a rat model of complement-dependent immune mesangial injury with induced glomerular nitric oxide (NO) synthesis. To examine mechanisms of inducible nitric oxide synthase (iNOS...

... was to explore a possible role for altered nitric oxide (NO) production or bioavailability in these hemodynamic responses. Methods: We explored the impact of CM (sodium iothalamate) upon rat renal NO synthase (NOS) activity (citrulline recovery) and NO (using a NO electrode). Results: The cortical NOS activity...

...Raymond J. MacAllister; Patrick Vallance In animals and humans, inhibition of nitric oxide (NO) production has widespread effects. Reduced activity of the NO:cyclic GMP pathway has been documented in disease states, including hypertension, diabetes and certain types of renal disease. Inhibitors...

... Transforming growth factor β Mitosis Apoptosis Neutrophil Macrophage Oxygen radical Nitric oxide During the past decade, numerous studies have been pursued to elucidate biological properties of transforming growth factor β (TGF-β), the pleiotropic and complex cytokine involved in a wide range...

... in the CsA (18±2 vs. 23±3 ng Ang I/ml/h, p < 0.05) and the L -NAME groups (vs. 30±3 ng Ang I/ml/h, p < 0.05). Nitric oxide production in L -Arg group was higher than in the CsA (24.2±1.7 vs. 11.1±1.5 µmol/24 h, p < 0.05) and the L -NAME groups (vs. 8.4±1.0 µmol/24 h, p < 0.05). In conclusion...

...M.P. Gordge Nitric oxide (NO) shows an unusual divergence of action, being utilised both as a physiological signalling molecule, and as a toxic mediator. NO-mediated cellular injury may arise by a variety of mechanisms, including disruption of mitochondrial respiration, enzyme inhibition, lipid...