... in non-diabetic mice. Microarray studies indicated that the accelerated fibrosis and cell infiltration in nephrectomized OVE mice were accompanied by corresponding gene expression changes in canonical pathways for fibrosis and inflammation. Conclusion: Uninephrectomy greatly accelerates all features...

...Lu Yang; Suzana Brozovic; Jianxiang Xu; Yunshi Long; Patricia M. Kralik; Sabine Waigel; Wolfgang Zacharias; Shirong Zheng; Paul N. Epstein Aim: To define renal gene expression during the development of severe albuminuria in OVE26 diabetic mice. Methods: Kidney microarray analysis was performed at 2...

... by subepithelial immune deposits, podocyte foot processes effacement and massive proteinuria beginning 4 days following disease induction. Although single genes involved in PHN have been studied, no whole genome-wide expression analysis of kidney tissue has been performed. Methods: Microarray analysis...

...Michael R. Bennett; Kimberly A. Czech; Lois J. Arend; David P. Witte; Prasad Devarajan; S. Steven Potter Focal segmental glomerulosclerosis (FSGS) is a major cause of end-stage renal disease. In this report we used laser capture microdissection to purify diseased glomeruli, and microarrays...

...Christer Betsholtz; Liqun He; Minoru Takemoto; Jenny Norlin; Ying Sun; Jaakko Patrakka; Karl Tryggvason Histopathology provides the current basis for classification and diagnosis of glomerular disorders. Molecular profiling methods, such as microarray analysis of mRNA expression, have rapidly...

... of parallel processing, robotics, and computer-based informatics, a number of high-throughput methods have been devised. These include DNA microarrays, serial analysis of gene expression, quantitative RT-PCR, differential-display RT-PCR, and massively parallel signature sequencing. Each of these methods has...

...Erwin P. Böttinger; Wenjun Ju; Jiri Zavadil Groundbreaking recent developments, such as the near completion of human and mouse genome sequencing efforts and the emergence of robust microarray (gene chip) technologies, enabling comprehensive analysis of transcriptomes, provide new opportunities...