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Keywords: Mesangial cells
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Journal Articles
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2011) 118 (2): e27–e38.
Published Online: 23 December 2010
...Hassan Khammas; Timothy Bowen; John David Williams; Aled Owain Phillips; Robert Steadman; John Martin Background: ADAM15 is a membrane-bound member of the adamalysin family that is up-regulated in areas of tissue remodelling. Previous studies have demonstrated the role of ADAM15 in mesangial cell...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2009) 113 (1): e16–e25.
Published Online: 09 July 2009
...Quancheng Feng; Songming Huang; Aihua Zhang; Qiuxia Chen; Xirong Guo; Ronghua Chen; Tianxin Yang Aims: To investigate the effects of Y-box protein 1 (YB-1) on the mitogen-activated protein kinase pathway to ascertain which signaling pathway is involved in YB-1-induced mesangial cell (MC...
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2008) 109 (1): e1–e7.
Published Online: 15 May 2008
... glomerulonephritis was induced in male Wistar rats with a monoclonal anti-rat Thy-1.1 antibody (OX-7) with rats randomized to receive either tranilast 400 mg/kg/day or vehicle control. Collagen synthesis and proliferation of cultured mesangial cells following incubation with PDGF (50 ng/ml) and tranilast (10–100 µ M...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2006) 103 (3): e103–e108.
Published Online: 22 March 2006
...Aditi A. Kapasi; Saijun Fan; Pravin C. Singhal HIV-1 gp120 protein has been shown to promote mesangial cell (MC) injury. Scatter factor (SF) is a growth factor that plays a reparative role in various experimental models of renal lesions. We hypothesize that SF protects MC against HIV-1 gp120...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Nephrology
Nephron Experimental Nephrology (2003) 93 (1): e23–e26.
Published Online: 17 November 2004
... Mesangial cells Regulation of signal transduction and gene expression is a multifaceted process involving ligands, receptors and second messengers that trigger cascades of protein kinases and phosphatases and propagate the signal to the nucleus to alter gene expression. Reduction-oxidation (redox...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Experimental Nephrology (2002) 10 (4): 241–244.
Published Online: 27 June 2002
... and development. Increased expression of gremlin has recently been demonstrated in several models of diabetic nephropathy. Gremlin arrests the cell cycle in mesangial cells and has also been shown to be upregulated in transdifferentiated renal proximal tubular cells. This review summarizes emerging evidence...
Journal Articles
Subject Area:
Nephrology
Experimental Nephrology (2002) 10 (4): 245–258.
Published Online: 27 June 2002
... dysfunction of GECs and mesangial cells can lead to persistent glomerular perturbations with prolonged phenotypic change of mesangial cells, resulting in end-stage renal deficiency. GEC damage during the acute nephritic phase contributes to the progression of irreversible renal disease. Expression plasmid...
Journal Articles
Journal Articles
Subject Area:
Nephrology
Experimental Nephrology (2001) 9 (6): 366–371.
Published Online: 07 November 2001
...), a component of the IGF system, has been shown to induce apoptosis in cancer cell lines. However, if IGFBP-3 has similar effects in human mesangial cells (HMC) remains unknown. The purpose of this study was to examine the expression of IGFBP-3 and its possible effect on the induction of apoptosis in HMC during...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Nephrology
Experimental Nephrology (2001) 9 (2): 65–70.
Published Online: 11 January 2001
... coinciding with the very early induction of mesangial injury. The present review is focused on apoptosis in relation to this model, and discusses recent findings concerning direct involvement of triggering of Thy-1 as well as deposition of terminal complement complexes in the induction of mesangial cell...
Journal Articles
Subject Area:
Nephrology
Experimental Nephrology (2000) 8 (4-5): 235–243.
Published Online: 31 July 2000
... TSHR transcript in the renal cortex of transgenic animals. TSHR transcript was also detected in mouse mesangial cells in vitro which responded to TSH with significant increases in the formation of three-dimensional hillhocks. Polymerase chain reaction also confirmed the presence of Tg transcript...
Journal Articles