...Jayne Hardy; Brett Hambly; Hongda Ko; Kate Wyburn; Josette Eris; Jianlin Yin Background/Aims: Mesangial cell (MC) hyperplasia is associated with several kidney diseases. Experimental studies confirm upregulation of IL-18 in glomerular disease and renal allograft rejection. We evaluated whether MCs...

...Masaaki Nameta; Eishin Yaoita; Nobutaka Kato; Linning Zhao; Ying Zhang; Hidehiko Fujinaka; Bo Xu; Yutaka Yoshida; Tadashi Yamamoto Background/Aims: Mesangial cells bear the tensional forces generated in the glomerular capillary wall. Not only mesangial cells per se, but also their intercellular...

... profile of differently charged IgA1 from IgAN patients. The binding characteristics of these IgA1 fractions to cultured human mesangial cells (HMC) and hepatoma cell lines (HepG2) were studied. Methods: Differently charged IgA1 were isolated by ion exchange chromatography. The glycosylation profile...

...Takayuki Koyama; Kazuhiko Hora; Shinji Ako; Yuji Kamijo; Makoto Higuchi Background: In pathological states various cytokines are produced by mesangial cells (MC) and contribute to disease progression. It is likely that interactions between monocytes and MC partially regulate these cytokines...

... to injury. This response to injury is largely cell-type specific, and the glomerulus represents a rare microcosm of the larger organism in which one can study the cellular responses of three very distinct cell types: mesangial cells, visceral epithelial cells or podocytes, and endothelial cells. These cells...

... glycoprotein 130. We investigated the in vivo antinephritic effect of ATRA on IL-6 transgenic mice which had developed mesangial proliferative glomerulonephritis (PGN) as well as its in vitro inhibitory effect on the proliferation of rat mesangial cells. In vivo experiments on IL-6 transgenic mice showed...

... Glomerulonephritis Systemic lupus erythematosus Mesangial cell Nephrotoxic nephritis Anti-glomerular basement membrane disease Lupus-prone mice Many forms of glomerulonephritis involve immune complex (IC) localization in the kidney. One of the most important classes of IC-binding receptors are the Fcγ...

... and control rats and in cultured mesangial cells from normal rats. Renal injury was marked in rats receiving L -NAME. Type I angiotensin II (AT 1) receptor number and mRNA expression were decreased (p < 0.05) in glomeruli isolated from L -NAME-treated rats compared with controls, unless they received...

...Jeffrey R. Schelling; Sumita Sinha; Martha Konieczkowski; John R. Sedor Myofibroblast differentiation characterizes a prominent cellular phenotype identified in experimental models of progressive kidney disease and human kidney biopsies. Mesangial cells, tubulointerstitial fibroblasts and, perhaps...

... injury. A typical example is its effect on oxidant-induced apoptosis of mesangial cells. Mesangial cells exposed to hydrogen peroxide undergo apoptosis through activation of the c-Jun N-terminal kinase activator protein 1 pathway. RA dramatically inhibits this process via suppression of c- fos /c- jun...

... of diabetic renal disease. Because the mesangial compartment is central to the fibrogenic response that evolves during the course of diabetic nephropathy, determining the metabolic influence of sulfonylureas on mesangial cells is important. In this article, the current knowledge regarding the metabolic...

... strategies for tracking bone marrow-derived cells, our system is highly sensitive and allows us to take advantage of the rat nephrology. Using this system, we have reported that bone marrow provides mesangial cells during repair process. In this manuscript, we briefly summarize our experiences. In order...

..., the localization of epimorphin protein and the expression of its mRNA were investigated in the developing mouse and adult human kidneys using immunohistochemistry and semiquantitative RT-PCR. The in vitro expression of epimorphin protein and its mRNA was also explored in cultured mouse and human mesangial cells...

...Keisuke Maruyama; Naoki Kashihara; Yasushi Yamasaki; Minoru Sato; Hitoshi Sugiyama; Kazunori Okamoto; Yohei Maeshima; Masahiro Odawara; Junzo Sasaki; Hirofumi Makino Glucocorticoid has long been used to treat patients with glomerulonephritis because it ameliorates mesangial cell proliferation...

...S.J. Mudge; J.L. McRae; R.B. Auwardt; B.F. Murphy; C.-G. Chen; D.A. Power Sublytic complement injury to glomerular mesangial cells, mediated by the terminal membrane attack complex of complement (C5b-9), is a potential initiating mechanism in IgA nephropathy. Sublytic complement injury has been...

... glomerulus include infiltrating leucocytes and mesangial cells, and the predominant isoform expressed is AI (AII predominates under physiological conditions). The recent identification of different isoforms of arginase has been an important step towards understanding the significance of arginase activity...

... two high-molecular-weight CaD (h-CaD) isoforms and four low-molecular-weight CaD (l-CaD) isoforms produced by alternative splicing. Isoformal interconversion is associated with phenotypic modulations of vascular SMC. We investigated the CaD isoform in human and rat glomerular mesangial cells (MC...

... proliferation requires that cyclin-dependent kinases (CDK) be activated by partner cyclins. Inhibiting CDK2 reduces mesangial cell proliferation. Mesangial cell proliferation also requires that levels of specific cyclin kinase inhibitors (CKI) decrease. In contrast, the visceral glomerular epithelial cells...

.... Towards this end, Fouqueray et al. [ 8 ]investigated the utility of IL-10 for the treatment of the autologous phase of antiglomerular basement membrane glomerulonephritis in rats. IL-10 vectors were created by transfection of mesangial cells with IL-10 cDNA. The cells were transferred into the nephritic...

... the renin-angiotensin system (RAS) in cultured rat mesangial cells. Type 1 Ang II receptor (AT 1 R) expression was assessed by 125 I-Ang II binding and quantitative reverse-transcription polymerase chain reaction. Stretch/relaxation increased steady-state AT 1 R mRNA levels as well as specific [ 125 I]Ang...