..., about the role of Wnt5a in kidney development, although WNT5A mutations were identified in patients with Robinow syndrome, a genetic disease which includes developmental defects in kidneys. Our goal in this study was to determine the role of Wnt5a in kidney development. Methods: Whole-mount in situ...

...Qiuxia Chen; Songzhou Xu; Songming Huang; Aihua Zhang; Quanchen Feng; Xirong Guo; Mei Guo; Ronghua Chen; Tianxin Yang Background: While early kidney development has been studied exhaustively, the later stages of nephrogenesis that occur after birth in the rodent are relatively poorly understood...

... Kidney development Cell adhesion molecules Transgenic mouse In vitro studies demonstrated that EpCAM is engaged in intercellular and cell-matrix interactions and also mediates cadherin-dependent cell adhesion [ 2, 3 ]. Additionally, EpCAM was shown to be involved in cell proliferation...

... Xenotransplantation Kidney development Xenotransplantation, primarily of pig organs, has been proposed as a possible means to alleviate the shortage in donor organs for kidney transplantation. Xenotransplantation of sterilized pig heart valves, foetal pancreatic islet cells, foetal neural cells, and porcine...

...Larry T. Patterson; S. Steven Potter Rapid determination of the expression levels of all genes can be achieved with microarrays. This technology is beginning to revolutionize the study of kidney development. Genome-wide expression studies of the developing rat, mouse and human kidneys have found...

... insights into normal kidney development as well as aberrations of this normal process that may result in renal dysplasia or pediatric renal malignancy (Wilms’ tumor). 17 11 2004 © 2003 S. Karger AG, Basel 2004 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... during kidney development. We investigated in the present paper whether the SBA-labeled molecules are associated with a new type of fiber or whether they colocalize with known extracellular matrix proteins such as laminin [ 19 ], fibronectin [ 20 ], tenascin [ 21 ]and collagens [ 20 ]. In addition, we...

... epithelial cells Transforming growth factor-β Bone morphogenetic proteins Gremlin drm Transdifferentiation Kidney development Glomerulosclerosis and tubulointerstitial fibrosis are pathological hallmarks of progressive renal disease. The molecular basis for sclerosis and fibrosis...

... of unprecedented scale for researchers of kidney biology and disease. Combined with advanced computational and mathematical approaches for microarray data analysis, microarray applications promise to revolutionize our understanding of molecular mechanisms of kidney development and renal pathogenesis. New knowledge...

...Jamie A. Davies; Carolyn E. Fisher Metanephric kidney development begins with the formation of the metanephrogenic mesenchyme; this event depends on the prior action in the intermediate mesoderm of transcription factors such as Lim-1, Pax-2, Eya-1, and Foxc-1. Once it has formed, the mesenchyme...

... from undifferentiated mesenchyme to the early stages of nephrogenesis. Less is known about the role of PAX8 in kidney development; although PAX8 is expressed in the S-shaped body and early proximal tubule, preliminary data suggest that renal morphogenesis is unaffected by its absence. In this review...