...Yelixiati Adelibieke; Maimaiti Yisireyili; Hwee-Yeong Ng; Shinichi Saito; Fuyuhiko Nishijima; Toshimitsu Niwa Background/Aims: Interleukin-6 (IL-6) is one of the inflammation biomarkers with highest predictive value for outcome in chronic kidney disease (CKD) patients. The present study aimed...

... were also decreased with LEC pretreatment of mice injected with Gly. Conclusion: These results support the hypothesis that depletion of macrophages prevents renal dysfunction by abrogating apoptosis and attenuating inflammation during AKI. © 2014 S. Karger AG, Basel Copyright / Drug Dosage...

...Xin Wan; Wen Juan Huang; Wen Chen; Hong-Guang Xie; Pan Wei; Xin Chen; Chang-Chun Cao Background: Renal ischemia-reperfusion (IR) injury is a frequent cause of acute kidney injury, which results in high morbidity and mortality. Inflammation is an important factor that is involved in kidney repair...

... cells in the affected area. Conclusion: Aging could play a major role in exaggerating the pathological processes of inflammation to fibrosis in remote organs including the heart and the nonischemic kidney after IR stimulation of the unilateral kidney. 7 06 2013 25 03 2014 3 07 2014...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2013 Oxidative stress Reactive oxygen species Inflammation Diabetic...

... in non-diabetic mice. Microarray studies indicated that the accelerated fibrosis and cell infiltration in nephrectomized OVE mice were accompanied by corresponding gene expression changes in canonical pathways for fibrosis and inflammation. Conclusion: Uninephrectomy greatly accelerates all features...

... to be markers of human advanced diabetic nephropathy and the NF-ĸB_IFN_x promoter module were elevated in the oldest diabetic mice. Vitamin D inhibits diabetic renal inflammation. Vitamin D and mRNA for vitamin D synthetic enzyme CYP2B1 were elevated in kidneys of young OVE26 mice. Conclusions: OVE26 mice...

.../profibrotic gene expression profile from HRPTEpiC isolated from three different donors was examined in response to IL-17A (0.1–100 ng/ml, 24 h) for comparison to the HK-2 human proximal tubule epithelial cell line. IL-17A upregulated the expression of a number of genes associated with inflammation...

... defense Inflammation Peritonitis Dialysis Omentum majus Adipocyte Isolated adipocytes were disseminated in 6- or 12-well plates in DME medium (+10% FCS, heat-inactivated) and were then either left unstimulated or were stimulated with tumor necrosis factor (TNF)-α (20 ng/ml; R&D Systems...

.... Wolfs TG, Buurman WA, van Schadewijk A, de Vries B, Daemen MA, Hiemstra PS, van ’t Veer C: In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. J Immunol 2002;168:1286–1293. 11801667 6...

..., structural injury, inflammation and aldosterone elevation after IR injury. One hour before the end of the 24-hour reflow period, the animals were anesthetized with sodium thiopental (70 mg/kg b.w., i.p.; n = 5–10 per experimental group) and they were prepared for renal clearance studies as previously...

... dysfunction, which can induce ER stress and the subsequent unfolded protein response (UPR). The UPR initially serves as an adaptive response, but will also induce apoptosis in cells under severe or prolonged ER stress. Oxidative stress and inflammation are compounded by ER stress via the UPR, suggesting...

... Cell therapy Tubule cells Tissue engineering Inflammation Nanotechnology Acute renal failure (ARF) is generally defined as an abrupt and sustained decline in the glomerular filtration rate (GFR), which leads to accumulation of nitrogenous waste products and uremic toxins. The term...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2007 Acute kidney injury Acute renal failure Hepatocyte growth factor Hepatocyte growth factor receptor c-met Apoptosis Inflammation Heme oxygenase Acute kidney injury...

... Proliferation, mesangial cells Spontaneously hypertensive rat, mesangial cells Hypertension Inflammation The pathophysiology of essential hypertension depends on a variety of interrelated factors, among which the genetic determinant is extremely important. The renin-angiotensin system (RAS) activity...

.... Libby P: Inflammation in atherosclerosis. Nature 2002;420:868–874. 12490960 10.1038%2Fnature01323 5. Ter Maaten JC, Smit AJ, Gans ROB: Idiopathic retroperitoneal fibrosis: idiopathic or secondary to atherosclerosis? Neth J Med 2000;56:35–37. 10710937 10.1016%2FS0300-2977%2899...

...Bärbel Lange-Sperandio; Michael S. Forbes; Barbara Thornhill; Mark D. Okusa; Joel Linden; Robert L. Chevalier Background: Renal interstitial inflammation is a consequence of unilateral ureteral obstruction (UUO). Following ischemia/reperfusion, adenosine reduces renal inflammation and injury...

... transduced macrophages localise preferentially in the presence of glomerular inflammation in rats and when macrophages are activated with lipopolysaccharide [ 13 ]. Retroviruses transduce rapidly dividing cells by stably incorporating DNA into the host cell genome, however, the transduction efficiency...

... Redox signaling Gene expression Inflammation Mesangial cells Regulation of signal transduction and gene expression is a multifaceted process involving ligands, receptors and second messengers that trigger cascades of protein kinases and phosphatases and propagate the signal to the nucleus...

... from any ideas, methods, instructions or products referred to in the content or advertisements. 2004 FACS Antibody Inflammation CCR2 CCR5 Blocking the interaction between leukocyte surface receptors and their specific ligands is an attractive therapeutic approach to reduce...