... advances in the field, including the impact of background strain, hypertension and transcriptomic profiling. While the C57BL/6J strain is relatively resistant to DN, the FVB strain appears more susceptible and Ove26 and db/db mice on this background may be useful in modelling types 1 and 2 DN, respectively...

... a comparative analysis of CTGF expression in hypertensive patients with and without nephrosclerosis, and in uninephrectomized and sham-operated spontaneously hypertensive rats (UNX-SHR and 2K-SHR). Results: Urinary and plasma CTGF were elevated in patients with hypertensive nephrosclerosis, and increased renal...

... from any ideas, methods, instructions or products referred to in the content or advertisements. 2009 Vascular endothelial growth factor Glomerular endothelial cells Glomerulopathy Diabetic nephropathy Pre-eclampsia Hypertension Hypertension often develops early in patients...

...Shai Efrati; Sylvia Berman; Eduard Ilgiyeav; Zhan Averbukh; Joshua Weissgarten Background/Aim: The angiotensin II level is elevated in subjects genetically prone to develop hypertension, triggering renal hypercellularity, cytokine production, and matrix deposition. Angiotensin-converting enzyme...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2004 Telomeres African Americans Caucasians Renal growth Sodium chloride Hypertension Models...

...Anil K. Bidani; Karen A. Griffin; Paul C. Churchill; Monique C. Churchill; Elizabeth St. Lezin; Theodore W. Kurtz Substantial evidence indicates that hypertension plays a predominant role in the progression of most chronic renal diseases including diabetic nephropathy. Nevertheless, significant...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Epithelial Na + channel Hypertension Genetic defects Pathophysiology The content of body fluid Na + is tightly regulated by the epithelial Na + channel (ENaC), which...

... Hypertension Transport Hemodynamics The prostaglandins (PG) are comprised of five major biologically active, naturally occurring cyclooxygenase metabolites of arachidonic acid, including thromboxane A 2 (TXA 2 ), PGE 2 , PGD 2 , PGF 2α , and prostacyclin (PGI 2 ) [ 1 ]. Many of their biologic...

... reached 87% in comparison with 61% in untreated rats. No mortality was observed in rats treated with the combination of verapamil and trandolapril. Trandolapril treatment prevented the development of hypertension. The combination verapamil-trandolapril did not induce further reduction on blood pressure...