.... So far, they have been ascribed 2 major functions: (1) PECs may act as intrinsic progenitor cells to replenish podocytes and/or proximal tubular cells and (2) a major role of PECs has been proposed in 2 glomerular disease entities [i.e. rapidly progressing glomerulonephritis (RPGN) and focal...

... investigated reversible glomerular injury in a mouse model of habu snake venom (HSV)-induced glomerulonephritis using AT1-R-deficient (AT1a-/-) mice and AT1-R antagonist-treated mice. Methods: Experimental glomerulonephritis was induced by single administration of HSV to AT1a+/+ mice (HSV group) and AT1a...

... for maintaining the myofibroblastic phenotype in pathological scar formation. To investigate the involvement of Hic-5 in the pathogenesis of glomerulonephritis (GN), we examined the glomerular expression of Hic-5 in human and rat GN as well as the regulation of Hic-5 by TGF-β 1 in vitro. Methods and Results...

... macrophages [ 15, 16 ]. Dendritic cells Glomerulonephritis Interstitial inflammation Experimental renal inflammation Dendritic cells (DCs) were first identified in the mouse as a discrete cell type in lymphoid organs (spleen) that were characterized by a large stellate morphology [ 1...

... inflammation. In the 1980s and early 1990s, major histocompatibility complex class II antigen- (HLA-DR) positive DCs were first described in normal human kidneys and in the interstitium of kidneys from patients with glomerulonephritis. Several DC subtypes were subsequently distinguished based...

... of TF (TF CT–/– mice) were used to study its role in physiological albuminuria and pathological proteinuria following induction of glomerulonephritis (GN). Results: Absence of the cytoplasmic domain of TF was associated with increased albuminuria, podocyte effacement, reduced podocyte numbers...

... of MC proliferation. Conclusions: These results demonstrate for the first time an important role for T-CaCN in human MC proliferation. This could potentially lead to a novel therapy in the treatment of proliferative renal diseases. Calcium channel Glomerulonephritis Human mesangial cell...

.... In systemic lupus erythematosus, stimulation of TLR7 and TLR9 by host-derived nucleic acids is important. TLR7 stimulation exacerbates disease, but the role of TLR9 is complex. I also discuss evidence that they are important in other forms of glomerulonephritis, with evidence derived mainly from experimental...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2007 Anti-glomerular basement membrane nephritis Glomerulonephritis...

...Yoshihiro Kudo; Yoshihiko Kakinuma; Mitsuko Iguchi; Takayuki Sato; Tetsuro Sugiura; Mutsuo Furihata; Taro Shuin Background/Aims: We previously demonstrated that angiotensin II (AII) combined with Habu snake venom (HV) induces glomerulonephritis (GN) in rats, with lesions being restricted...

...Fahima Khan; Kazuo Yamakami; Javed Mahmood; Bing Li; Tamami Kikuchi; Naoki Kumagai; Tetsuo Morioka; Nobuyuki Yoshizawa; Takashi Oite Background: Acute post-streptococcal glomerulonephritis (APSGN) is induced by glomerular deposition of nephritogenic streptococcal antigen-antibody complexes...

...Jesus Mosquera; Maritza Romero; Ninoska Viera; Jaimar Rincon; Adriana Pedreáñez Acute poststreptococcal glomerulonephritis (APSGN) is a consequence of the immune response to streptococcal antigens with further in situ antigen-antibody interaction and deposition of circulating immune complexes...

...-ANCA in Brown-Norway rats immunized with human MPO did not appear to induce renal vasculitis [ 23 ]. However, unilateral perfusion of the left kidney with a neutrophil extract, containing MPO, and hydrogen peroxide (H 2 O 2 ), induced severe necrotizing crescentic glomerulonephritis only in MPO...

...-peroxidase complex using a Vectastain ABC kit (Vector Laboratories, Burlingame, Calif., USA). Glomerulonephritis Collagen type IV Gelatinase A The rat kidneys were perfused with 4% paraformaldehyde and 0.1 M phosphate buffer (pH 7.4) and immersed in the same fixative for 2 h. Tissue...

...Patrick H. Maxwell; Yiming Wang IgA nephropathy is the commonest form of glomerulonephritis worldwide, but we still know relatively little about its pathogenesis. Potentially, genetic studies might provide new insights and suggest novel therapeutic approaches to this important cause of chronic...

...Toshiaki Monkawa; Jeffrey Pippin; Yoshikage Yo; Jeffrey B. Kopp; Charles E. Alpers; Stuart J. Shankland Background: Mesangial cell (MC) proliferation underlies increased matrix accumulation in glomerulonephritis (GN), and the resolution of MC proliferation occurs largely through apoptosis...

...Ping Li; Yuewen Gong; Ning Zu; Yajun Li; Bin Wang; Fujio Shimizu Aims: Mesangioproliferative glomerulonephritis is a common kidney disease and at present, there is no effective treatment. Our previous studies have demonstrated that Sairei-to can significantly prevent progression of experimental...

... glycoprotein 130. We investigated the in vivo antinephritic effect of ATRA on IL-6 transgenic mice which had developed mesangial proliferative glomerulonephritis (PGN) as well as its in vitro inhibitory effect on the proliferation of rat mesangial cells. In vivo experiments on IL-6 transgenic mice showed...

...Yoshihiro Kudo; Yoshihiko Kakinuma; Yasukiyo Mori; Norihito Morimoto; Takashi Karashima; Mutsuo Furihata; Takayuki Sato; Taro Shuin; Tetsuro Sugiura Background/Aim: Among various kidney disease models, there are few rat glomerulonephritis (GN) models that develop in a short time, and with mainly...

...Ruth M. Tarzi; H. Terence Cook Many forms of glomerulonephritis involve immune complex localization in the kidney. Fcγ receptors (FcγR) expressed on the surface of leukocytes bind the Fc (constant) portion of IgG. They link immune complex deposition to innate immune responses, including...