... on barrier integrity as indicated by ZO-1 downregulation. Fibrosis Cytokine Inflammation Tubulointerstitial fibrosis has been shown to play a critical role in the pathogenesis of renal injury to end-stage renal failure and the proximal tubule cell has been revealed as a central mediator [ 1, 2...

...Yasuhiko Ito; Jan Aten; Tri Q. Nguyen; Jaap A. Joles; Seiichi Matsuo; Jan J. Weening; Roel Goldschmeding Background/Aims: Connective tissue growth factor (CTGF; CCN2) has been implicated as a marker and mediator of fibrosis in human and experimental renal disease. Methods: We performed...

... function in CRF rats after 8 weeks which was accompanied by decreased collagen deposition, renal fibrosis and interstitial macrophage infiltration. Remarkably, these renoprotective effects did not show the same dose dependency as compared to that seen for the hematopoietic response and were also seen...

... and progressive renal fibrosis. This study was designed to explore if exogenous all- trans retinoic acid (tRA) prevents renal fibrosis in this animal model. Methods: The retinoid profile in kidney and liver of wild-type and Alb/TGF-β 1 transgenic mice was examined by high-performance liquid chromatography...

... conventional and biocompatible PD solutions with different glucose concentrations affect morphological and functional signs of peritoneal fibrosis as well as the TGF-β1/Smad signaling pathway in a chronic PD rat model. Methods: Non-uremic male Wistar rats (n = 28) were dialyzed thrice daily for 28 days with 20...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2008 Bone marrow Bone marrow-derived stem cells Embryonic stem cells Fibrosis Native renal stem cells Renal regeneration Stem cells In the 20th century...

..., Georgetown University Medical Center, Washington, D.C., USA Key Words Warm ischemia Reperfusion injury Peripheral-type benzodiazepine receptor Fibrosis Renal regeneration Abstract The peripheral benzodiazepine receptor (PBR) is located mainly in the outer mitochondrial membrane and many functions...

.... The pathologic lesions of diabetic nephropathy include glomerular fibrosis and mesangial expansion, which result from ECM accumulation. These lesions, once established, were formerly thought to be irreversible [ 15 ]; however, the ECM does undergo remodeling and its quantity is determined by the rates...

.... 2006 Mouse models Diabetic nephropathy C57BL/6 Streptozotocin db/db Advanced glycation end products Oxidative stress Fibrosis Diabetic nephropathy is the single major cause of end-stage renal failure in the USA and Europe [ 1 ]. Despite current treatments, involving glycaemic...

...Nurit Haran; Ludmila Leschinski; Mark Pines; Jayson Rapoport Background/Aim: Interstitial fibrosis is the final common pathway of renal damage and represents an important therapeutic target. Halofuginone is a nontoxic alkaloid, used as a coccidiostat, and is a potent inhibitor of collagen α 1 (I...

... levels varied over time in culture and with exposure to TGF-β 1 . Thus, depending on which reference gene was used, TGF-β 1 appeared to have different effects on expression of MKL1 and αSMA. Conclusions: RTC converting to myofibroblasts in primary culture is a valuable system to study renal fibrosis...

...Mysore K. Phanish; Nadia A. Wahab; Bruce M. Hendry; Mark E.C. Dockrell Background: Connective tissue growth factor (CTGF, CCN2) plays a fundamental role in the development of tissue fibrosis by stimulating matrix deposition and mediating many of the pro-fibrotic effects of transforming growth...

...Bo Kyung Sun; Can Li; Sun Woo Lim; Bum Soon Choi; Suk Hee Lee; In San Kim; Yong Soo Kim; Byung Kee Bang; Chul Woo Yang Background: We recently demonstrated that upregulation of the transforming growth factor (TGF)-β1 inducible gene-h3 (βig-h3) is associated with tubulointerstitial fibrosis (TIF...

..., fibrosis, and intrarenal vasoconstriction. Possible strategies for such modulation could include the use of RNA-interacting agents such as antisense DNA and si-RNA and the use of small molecules acting on Ras directly or on related signalling molecules such as Rho kinase and Raf kinase. Ras Rho...

... dedifferentiation and detachment from TBM with matrix production in concert with FLC activation, resulting in tubulointerstitial damage characterized by tubular atrophy and renal fibrosis. Proximal tubule Matrix production Fibrosis Tubular basement membrane Chronic renal ischemia is considered as one...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2004 cAMP cGMP Connective tissue growth factor Fibrosis...

... is associated with the loss of peritubular capillaries, impairing blood delivery. Associated interstitial fibrosis further impairs oxygen diffusion and supply to tubular and interstitial cells. This in turn exacerbates chronic hypoxia in this compartment, resulting in a vicious cycle. Both singly or together...

... kidneys activates the renin-angiotensin system and increases renin expression in the kidneys and serum. Calcium oxalate Nephrolithiasis Reactive oxygen species Fibrosis Formation of calcium oxalate (CaOx) kidney stones is the result of cellular as well as extracellular events...

...Timothy S. Johnson; John L. Haylor; Graham L. Thomas; Marie Fisher; A. Meguid El Nahas Renal fibrosis is characterised by an excessive accumulation of extracellular matrix (ECM) proteins. Evidence suggests that this results from both increased ECM synthesis and a reduced degradation. Here, we...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Urokinase receptor Glomerulonephritis Fibrosis Fibrinolysis Fibrin deposition combined with glomerular cell proliferation and monocyte-macrophage infiltration is the hallmark of immune...