... investigates the role of p38 mitogen-activated protein (MAP) kinase and Smad pathways in the TGFβ1-induced fibronectin (FN) production. Methods: Transformed human proximal tubular epithelial cells of the line HKC were used. Secreted FN was analyzed by enzyme-linked immunosorbent assay and Smad proteins...

... was inhibited by SC58236 treatment (to 1.84 ± 0.32 fold control). Immunoreactive TGF-β 1 , connective tissue growth factor, HGF receptor, c-Met, and fibronectin all increased in remnant (2.85 ± 0.51, 3.83 ± 0.55, 2.56 ± 0.31, and 2.80 ± 0.39 fold sham respectively, n = 4–8, p < 0.05), and SC58236 blunted...

... of renal damage due to stimulation of extracellular matrix molecule deposition. In fact, the in vitro TGF-β-mediated production of fibronectin, one of the major TGF-β-regulated extracellular components, has recently been correlated with Rho protein signalling molecules. Although a close relationship...

... in the bladder is that of Wilson et al. [ 19 ]; however, only integrin receptors for laminin, and RGD integrins were described. No specific collagen integrins were investigated. We have unpublished data showing that the expression of the fibronectin receptor integrin α 5 β 1 is upregulated antenatally...

... in the modulation of renal proximal tubular type-IV collagen and fibronectin turnover by glucose. Methods: The effect of glucose on type-IV collagen and fibronectin generation was studied by exposure of primary cultures of human renal proximal tubular cells (HPTC) to elevated D -glucose concentrations. Subsequently...