...F. Nutter; A. Khwaja; J. Haylor Background: 5/6 subtotal nephrectomy (SNx) is a non-immune stimulus used to induce renal fibrosis. The ability of seliciclib, a cyclin-dependent kinase inhibitor, to reduce kidney hypertrophy and extracellular matrix (ECM) deposition has been examined in the SNx rat...

...: Immunohistochemical analyses showed that the expression of Hic-5 was increased in mesangial cells (MCs) in human mesangial proliferative GN. Hic-5 expression was significantly correlated not only with the levels of α-smooth muscle actin (α-SMA) and TGF-β 1 , the accumulation of extracellular matrix, and the number...

...Lynetta M. Phillips; Ying Wang; Tiane Dai; David L. Feldman; Janine LaPage; Sharon G. Adler Background/Aims: Altered extracellular matrix (ECM) remodeling and podocyte apoptosis are characteristic features of diabetic nephropathy (DN). Aliskiren (ALI) inhibits the renin-catalyzed conversion...

...Markus Porst; Christoph Daniel; Christian Plank; Harald O. Schocklmann; Dieter P. Reinhardt; Andrea Hartner Background: Latent transforming growth factor-β-binding protein 1 (LTBP-1) and fibrillin-1 were shown to colocalize and interact in the extracellular matrix of the skin and vasculature...

... the changes in intrarenal pressure in UUO. We sought to determine the effect of meloxicam (a selective cyclooxygenase-2 inhibitor) on extracellular matrix and TGF-β synthesis in stretched renal fibroblasts (NRK-49F). Methods: NRK-49F cells were subject to cyclic stretch (6 cycles/min, 15% elongation) using...

... ]. Shihab et al. [ 16 ]reported that TGF-β1 plays an important role in fibrosis arising from chronic CsA nephrotoxicity, probably by its effects on extracellular matrix (ECM) synthesis and degradation. Indeed, administration of neutralizing anti-TGF-β antibody abrogates CsA-associated structural damage [ 17...

...Ambra Pozzi; Roy Zent Integrins are a large family of transmembrane receptors for extracellular matrix (ECM) molecules. They play a critical role in organ morphogenesis, physiology and pathology, as they can modulate and control different cell functions, including adhesion, shape, polarity, growth...

...S. Morano; R. Cipriani; M.G. Cerrito; C. Santangelo; F. Vasaturo; F. Pantellini; M. Sensi; L. Guidobaldi; S. Scarpa; U. Di Mario Background/Aim: Extracellular matrix alterations are involved in the pathogenesis of diabetic nephropathy. We evaluated the effects of high glucose concentrations...

... of extracellular molecules at this site was carried out. Double labeling showed that the micro-fibers do not correspond to known collagens and other extracellular matrix molecules such as agrin, versican or MMP-9. In addition, it could be demonstrated that the micro-fibers do not contain epithelial or mesenchymal...

... development. In this review we describe our current knowledge of the molecular processes that govern bladder development, with particular emphasis on the role of the extracellular matrix. Finally, we suggest a hypothetical model for bladder development. The only systematic review of integrin expression...

.... Fibrogenesis Hypertrophy Extracellular matrix Mesangial cells Tubule epithelial cells Transforming growth factor-β Bone morphogenetic proteins Gremlin drm Transdifferentiation Kidney development Glomerulosclerosis and tubulointerstitial fibrosis are pathological hallmarks of progressive renal...

...Timothy S. Johnson; John L. Haylor; Graham L. Thomas; Marie Fisher; A. Meguid El Nahas Renal fibrosis is characterised by an excessive accumulation of extracellular matrix (ECM) proteins. Evidence suggests that this results from both increased ECM synthesis and a reduced degradation. Here, we...

... the proangiogenic factors basic fibroblast growth factor [ 15, 16 ]and vascular endothelial growth factor (VEGF) [ 17, 18 ], the extracellular matrix-degrading matrix metalloproteinases (MMP-2 and MMP-9) [ 19, 20 ], angiogenin [ 21 ], and the cell-to-cell adhesion molecule E-cadherin [ 22 ]have been studied...

...M. Carmen Iglesias-de la Cruz; M. Piedad Ruiz-Torres; F. Javier De Lucio-Cazaña; Manuel Rodríguez-Puyol; Diego Rodríguez-Puyol The progression of chronic renal diseases is characterized by the accumulation of extracellular matrix proteins in the glomerulus. The present experiments were designed...

... important cells for the production and degradation of extracellular matrix and are assumed to play a pivotal role in renal interstitial fibrosis, which correlates directly with the decrease in excretory renal function. Renal fibroblasts also have endocrine activity: cortical fibroblasts are supposed...

... of this hypothesis, in vitro studies show that hypoxia (1% O 2 ) induces a fibrogenic phenotype in human renal tubular endothelia, interstitial fibroblasts and microvascular endothelial cells, simultaneously increasing extracellular matrix (ECM) production and decreasing turnover via effectors on matrix-degrading...

...Jill T. Norman; Leon G. Fine Progressive renal disease is characterized by expansion of the tubulo-interstitium and accumulation of extracellular matrix within this tissue compartment. Interstitial fibroblasts are the primary producers of the interstitial matrix, and in the evolution of tubulo...

... and composition of the surrounding extracellular matrix. Conversely, components of the embedding matrix affect the mesangial cell phenotype. These interactions are mediated via specific cell surface receptors, the best studied group of which is the β 1 integrin family. The β 1 integrins play a role in mesangial...

.... The aims of the study were to examine the effects of factors of proximal tubular origin on renal fibroblasts expressing different levels of smooth muscle actin (SMA; a putative marker of fibroblast activation) and to examine the modulation of SMA by extracellular matrix (ECM) proteins and transforming...