...Yonggui Wu; Yan Wang; Xiangming Qi; Pei Zhang; Chaoqun Zhang; Wei Zhang Background/Aims: Accumulating evidence suggests that macrophage-induced inflammation may be the mechanism of development and progression of diabetic nephropathy. A previous study by our group has shown that tacrolimus, like...

...Boris Betz; Bryan R. Conway Diabetic nephropathy (DN) is the single most common cause of end-stage kidney disease. Therefore, it is imperative that novel therapies are developed. Progress has been hindered, however, by the lack of robust animal models. In the current review we describe recent...

...Hua Jin; Shang Guo Piao; Ji Zhe Jin; Ying Shun Jin; Zhen Hua Cui; Hai Feng Jin; Hai Lan Zheng; Jin Ji Li; Yu Ji Jiang; Chul Woo Yang; Can Li Background: Leflunomide (LEF) and benazepril have renoprotective effects on diabetic nephropathy (DN) through their anti-inflammatory and anti-fibrotic...

... as appropriate. p < 0.05 was considered significant. 22 04 2013 14 01 2014 28 02 2014 Diabetic nephropathy Inflammatory cytokines Mineralocorticoid receptor Obesity Rac1 The prevalence of end-stage renal disease is rapidly increasing worldwide, and this increment...

... effects. In this study, we focused on the effect of PGZ on glomerular hyperfiltration (GHF), resultant glomerular injury and altered macula densa signaling as a cause of sustained GHF through modified tubuloglomerular feedback in rats with diabetic nephropathy. Methods: Kidneys from 24-week-old male OLETF...

...S.N. Verouti; E.C. Tsilibary; E. Fragopoulou; C. Iatrou; C.A. Demopoulos; A.S. Charonis; S.A. Charonis; G.I. Drossopoulou Background: Vitamin D is beneficial in human and experimental chronic kidney disease, the leading cause of which is diabetic nephropathy. Vitamin D through its receptor, VDR...

... diabetic nephropathy, because of its renoprotective effects. However, the mechanism by which telmisartan prevents proteinuria and renal dysfunction in diabetic nephropathy is still unclear. In this study, we examined the effects of telmisartan against diabetic nephropathy in db/db mice. Methods...

... topic of research. Recent evidence indicates that hyperuricemia is associated with increased TGF-β 1 and progressive tubulointerstitial injury. We examined the hypothesis that lowering serum uric acid attenuates TGF-β 1 -induced profibrogenic tubular change in type 2 diabetic nephropathy. Methods: KK...

.... 2012 Tempol Poly(ADP-ribose) polymerase Diabetic nephropathy Albuminuria Oxidative stress Apoptosis Podocyte Podocytes or glomerular visceral epithelial cells are important components of the integrity of the glomerular filtration barrier [ 1, 2, 3 ]. It has been demonstrated...

...Shirong Zheng; Yun Huang; Lu Yang; Teresa Chen; Jianxiang Xu; Paul N. Epstein Background/Aims: OVE26 (OVE) mice provide a valuable model of advanced diabetic nephropathy (DN), but they take 8 months to develop moderate interstitial fibrosis and reduced glomerular filtration rate (GFR). The aim...

... to be markers of human advanced diabetic nephropathy and the NF-ĸB_IFN_x promoter module were elevated in the oldest diabetic mice. Vitamin D inhibits diabetic renal inflammation. Vitamin D and mRNA for vitamin D synthetic enzyme CYP2B1 were elevated in kidneys of young OVE26 mice. Conclusions: OVE26 mice...

... macrophages in other renal diseases such as diabetic nephropathy remains unknown. Methods: Macrophages were separated from splenocytes and polarized with IL-4 and IL-13 into a protective phenotype. Mice underwent adoptive transfer with M2 macrophages, and then diabetes was induced by tail vein injection...

...Lynetta M. Phillips; Ying Wang; Tiane Dai; David L. Feldman; Janine LaPage; Sharon G. Adler Background/Aims: Altered extracellular matrix (ECM) remodeling and podocyte apoptosis are characteristic features of diabetic nephropathy (DN). Aliskiren (ALI) inhibits the renin-catalyzed conversion...

... with diabetic nephropathy, they may induce a compensatory increase in renin. Renin exhibits profibrotic actions independent of angiotensin II, which is regulated by extracellular signal-regulated kinase 1 and 2 (ERK1/2). Calcitriol (1,25(OH) 2 D 3 ) is a negative inhibitor of the renin-angiotensin system...

...Christiane Ruester; Sybille Franke; Tzvetanka Bondeva; Gunter Wolf Background: Podocyte damage and accumulation of advanced glycation end-products (AGEs) are implicated in the development and progression of diabetic nephropathy. We have previously shown that changes in podocyte pathophysiology...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2010 Decorin Transforming growth factor &#946;1 Smad Albuminuria Diabetic nephropathy Diabetic nephropathy (DN) is a major long-term complication...

...) has a protective effect on lipid peroxidation. Adiponectin and AMPK might have a role in the pathogenesis of diabetic nephropathy. Blockade of the renin-angiotensin system (RAS) increases adiponectin levels and reduces oxidative stress. The objective of the present study was to examine lipid...

... from any ideas, methods, instructions or products referred to in the content or advertisements. 2009 Vascular endothelial growth factor Glomerular endothelial cells Glomerulopathy Diabetic nephropathy Pre-eclampsia Hypertension The glomerulus forms the filtering component of each...

...Xianhua Li; Yunling Xiao; Haiqing Gao; Baoying Li; Ling Xu; Mei Cheng; Bei Jiang; Yabing Ma Background: Diabetic nephropathy (DN) is the most common cause of end-stage renal failure. Grape seed proanthocyanidin extracts (GSPE) are powerful antioxidants. However, the role of GSPE on advanced...

...David W. Powell; Clinton C. Bertram; Timothy D. Cummins; Michelle T. Barati; Shirong Zheng; Paul N. Epstein; Jon B. Klein Background/Aims: Tubulointerstitial fibrosis (TIF) is a prominent feature of progressive diabetic nephropathy. The goal of this study was to determine if hallmarks of TIF occur...