... that in control gas-treated counterparts. Renal histological analysis revealed that the formation of proteinaceous casts and tubular necrosis was improved by H 2 gas inhalation. Mechanistic analyses showed that inhalation of H 2 gas significantly reduced renal cell apoptosis, expression of cleaved caspase 3...

...Takuya Yoshida; Hiromichi Kumagai; Tetsuya Kohsaka; Naoki Ikegaya Background: Cisplatin (CDDP)-induced acute kidney injury (AKI) involves pro-inflammatory responses, apoptosis of renal tubular epithelial cells and vascular damage. AKI increases the risk of chronic kidney disease. Relaxin (RLX) has...

... were also decreased with LEC pretreatment of mice injected with Gly. Conclusion: These results support the hypothesis that depletion of macrophages prevents renal dysfunction by abrogating apoptosis and attenuating inflammation during AKI. 25 11 2013 10 07 2014 5 11 2014 © 2014 S...

...Yifei Yang; Dingwei Yang; Dingping Yang; Ruhan Jia; Guohua Ding Background: Renal tubular cell apoptosis is a key mechanism of contrast-induced acute kidney injury. It has been reported that endoplasmic reticulum (ER) stress is the underlying mechanism of high osmolar contrast-induced renal tubular...

... by real-time PCR. The levels of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and caspase-3 activity were measured. Results: Exposure of rat PMCs to 2.5% glucose PDFs for 24 h resulted in a significant induction of apoptosis, which was attenuated by NaHS. NaHS also restored the 2.5...

..., its nephrotoxicity is characterized by reduced renal perfusion and a concentrating defect, whereas morphologically, its effect on cell fate is characterized by necrosis of the terminal portion of the proximal tubule and apoptosis, predominantly in the distal nephron [ 3 ]. DDP-induced acute renal...

...David M. Small; Nigel C. Bennett; Sandrine Roy; Brian G. Gabrielli; David W. Johnson; Glenda C. Gobe Background: The incidence and cost of chronic kidney disease (CKD) are increasing. Renal tubular epithelial cell dysfunction and attrition, involving increased apoptosis and cell senescence...

...-polymerase chain reaction (RT-PCR) and Western blotting in RAW264.7 cells and kidney tissues. The levels of serum creatinine and blood urea nitrogen (BUN) and the renal histopathology assessment were determined at 6-, 12-, and 24-hour time points after CLP, and renal cell apoptosis was studied at 24 h. The 4...

... in attenuation of ER stress. We examined whether and how activation of AMPK suppressed the albumin-induced ER stress and apoptosis in tubular epithelial cells. Method: HK-2 cells, a proximal tubular cell line, were used. Protein expressions were measured by Western blot analysis. Intracellular ROS and apoptosis...

... translocation and activation of FoxO target genes [ 10 ]. FoxO protects cells from oxidative stress by upregulating the antioxidant enzyme manganese superoxide dismutase (MnSOD) [ 11 ] and promotes apoptosis signaling by inducing the pro-apoptotic protein Bim [ 12 ] and caspase activation [ 13 ]. Recently...

...Taiko Yoshida; Akira Shimizu; Yukinari Masuda; Akiko Mii; Emiko Fujita; Kaoru Yoshizaki; Seiichiro Higo; Go Kanzaki; Yusuke Kajimoto; Hideki Takano; Yuh Fukuda Background/Aims: Renal tubular cell death in ischemia-reperfusion does not follow the classical apoptosis or necrosis phenotype. We...

...) polymerase (PARP)-1 and podocyte loss by apoptosis contribute to albuminuria in diabetes mellitus (DM). In the present study, we investigated the hypothesis that in DM tempol reduces albuminuria by inhibition of PARP-induced podocyte apoptosis. Methods: DM was induced in 4-week-old spontaneously hypertensive...

...Bin Sun; Chao Lu; Guo-Ping Zhou; Chang-Ying Xing Background: Oxidative stress is an important inducer of cell apoptosis and plays a key role in the development of renal inflammation. The prostate apoptosis response factor-4 (Par-4) gene was originally identified in prostate cells undergoing...

...Young Mo Lee; So Yon Bae; Nam Hee Won; Heui Jung Pyo; Young Joo Kwon Background: Renal tubule cell apoptosis plays a pivotal role in cisplatin-induced nephrotoxicity. α-Lipoic acid (LA), a thiol antioxidant, is well known to be cytoprotective in various cell death models through its involvement...

.... It is, however, unknown whether there is a direct injurious effect of ALD on podocytes. Therefore, in the present study, we evaluated the effect of ALD on podocyte apoptosis and studied the role of phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) and p38 mitogen-activated protein kinase (p38MAPK) signaling pathways...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2008 Acute renal failure Vasodilatation Nitric oxide Apoptosis Glomerulus Tubule Afferent arteriole Efferent arteriole Glomerular filtration rate Severe...

... ± 0.38 vs. 1.07 ± 0.29 l/day, p < 0.01), decreased glomerular cell proliferation (15.8 ± 1.2 vs. 31.2 ± 0.8 nuclei/glomerular cross-section) and mesangial matrix deposition, and an increase in glomerular and tubular apoptosis without inducing any obvious adverse effects. Conclusion: DHMEQ inhibited NF...

... of glomerular injury characterized by proteinuria, protect podocytes from undergoing apoptosis induced by puromycin aminonucleoside (PA). However, the precise mechanisms underlying the beneficial effects of glucocorticoids on podocytes remain to be fully elucidated. Methods: To clarify the role of p53...

... cultured podocytes were subjected to albumin in vitro. We analyzed albumin uptake, podocyte apoptosis, staining for F-actin and nephrin and involvement of TGF-β1 and p38 MAPK cascades. Results: Rats administered albumin exhibited massive proteinuria and podocyte injury manifested by decreased nephrin...

...Jianzhong Wang; Chun Ouyang; Xiangmei Chen; Bo Fu; Yang Lu; Quan Hong Background/Aims: Apoptosis has been implicated in renal ischemic injury, the regulating mechanism of which is still unclear. Signal transducers and activators of transcription (STAT) participate in inflammation, apoptosis...