...Michael E. Ullian; Louis M. Luttrell; Mi-Hye Lee; Thomas A. Morinelli Objective: Since peritoneal dialysis causes peritoneal fibrosis, we examined how glucose (osmotic factor), mannitol (osmotic control), and angiotensin II (AngII) regulate proinflammatory cyclooxygenase 2 (COX-2) in primary rat...

...Waka Hayashi; Yoko Obata; Tomoya Nishino; Shinichi Abe; Kumiko Io; Akira Furusu; Katsushige Abe; Masanobu Miyazaki; Takeshi Sugaya; Takehiko Koji; Shigeru Kohno Background/Aims: To examine the role of the angiotensin II (ATII) type 1a receptor (AT1-R) pathway in renal tissue damage and repair, we...

... and structure, and tubulointerstitial inflammation at 21 days of age that were associated with apoptosis and oxidative stress. Angiotensin II Angiotensin II receptor Lactation Losartan Renal development Fifty-eight 21-day-old male Wistar rats born from 32 pregnant females were housed...

... 28 07 2010 MCs are also known to respond to a wide range of bioactive mediators that play an important role in kidney disease and its progression [ 2, 5 ]. Infiltrating leukocytes, platelets and other glomerular cells secrete a variety of agents that stimulate MCs. PDGF-BB and angiotensin II...

...), angiotensin II (Ang II) or HG. Results: Alpha-SM actin mRNA, protein and promoter activity were reduced to significantly lower levels in 3-D cells compared to cells in 2-D. Up-regulation of α-SM expression was stimulated by ET-1, Ang II and HG. Specific inhibitors of protein kinase C (PKC)-α, -β or -ζ...

...Shai Efrati; Sylvia Berman; Eduard Ilgiyeav; Zhan Averbukh; Joshua Weissgarten Background/Aim: The angiotensin II level is elevated in subjects genetically prone to develop hypertension, triggering renal hypercellularity, cytokine production, and matrix deposition. Angiotensin-converting enzyme...

...Patrick J. Flannery; Robert F. Spurney Background/Aims: Activation of angiotensin II (ANG2) receptors stimulates extracellular signal-regulated kinases (ERKs) that, in some cell systems, are mediated by transactivating the epidermal growth factor (EGF) receptor (EGFR) through mechanisms involving...

... Connective tissue growth factor Angiotensin II Hypertrophy Renal tubular cell Adaptive renal growth is an important feature of many chronic renal diseases such as diabetic nephropathy (DN) and remnant kidney, which has been proposed as a precursor of the development of chronic renal scarring...

... glomerular lesions. Hypoxia-inducible factor (HIF)-1α is a transcriptional factor that induces genes supporting cell survival, but the involvement of HIF-1α in attenuating the progression of GN remains to be elucidated. We developed a new model of rat GN by coadministration of angiotensin II (AII) with Habu...

... as scavenging by superoxide dismutase (SOD) activity. This study was designed to investigate the effects of high glucose (HG) on O 2 ·– accumulation and SOD activity in human mesangial cells (HMC) and to determine if these effects are mediated by angiotensin II (Ang II). Methods: HMC were incubated in media...

...Peter Benöhr; Simone Harsch; Barbara Proksch; Christoph H. Gleiter Background: In humans, infusion of angiotensin II increases erythropoietin (EPO) serum levels in a dose-dependent manner. However, it is not known whether angiotensin II stimulates EPO-producing renal fibroblasts directly via...

...Sophie Vandermeersch; Vadislav Stefanovic; Annette Hus-Citharel; Raymond Ardaillou; Jean-Claude Dussaule; Dominique Chansel Chronic inhibition of nitric oxide synthase promotes renin-dependent hypertension and renal injury. The present study examines how renal angiotensin II receptors are expressed...

... blocked this antiporter activation, the supernatant concentration of endothelin I (ET-I) and angiotensin II (Ang-II) were measured. The ET-I concentration was reduced, but the Ang-II concentration remained unchanged. There was a significant association between a reduction in the ET-I concentration...

.... Angiotensin II Osteopontin Renal failure The renin angiotensin system (RAS) plays a pivotal role in the development of progressive renal injury and hypertension following subtotal nephrectomy (STNx) in rats. Therapeutic approaches including administration of an angiotensin-converting enzyme...

...Fabrice Bonnet; Zemin Cao; Mark E. Cooper Apoptosis plays a key role in the regulation of normal renal structure and kidney remodeling in various renal diseases. Angiotensin II plays a prominent role in renal injury through its receptor subtypes, the type 1 (AT1) receptor and the type 2 (AT2...

... of the c-fos promoter by angiotensin II (AII), transient transfection experiments were performed in CHO cells stably expressing the rat AT 1A receptor. In this system AII activated ERK in 1 min and also increased the transcriptional activity of the c-fos promoter-luciferase reporter gene construct...

...Dirk De Craemer; Emmanuel Lobe; Marina Pauwels; Dierik Verbeelen; Christiane van den Branden Angiotensin II administration to rats during 6 weeks causes decreased activity of catalase and glutathione peroxidase in renal cortex. Rats show mild hypertension, subclinical signs of renal injury...

... functions and to pathological conditions with progression towards sclerosis. The function of endothelin 3 (Et3) at the renal level is debatable, but it could have an important regulatory function in the reabsorption of water through its action on tubular type B receptors. Angiotensin II has recently been...

...Norimoto Yanagawa Recent studies have revealed the existence of intrarenal renin-angiotensin system and broadened our understanding on the role of angiotensin II in the regulation of proximal tubular functions. The aims of the present review are to summarize these recent findings and to highlight...

...-chemoattractant protein-1 (MCP-1) occurs before influx of M/M and a neutralizing anti-MCP-1 antibody reduced this cell infiltrate by one third. The present study was undertaken to test the effect of two angiotensin II type 1 (AT 1 ) receptor antagonists, losartan and irbesartan, on ATS-stimulated MCP-1 expression...