..., instructions or products referred to in the content or advertisements. 2012 Acute kidney injury Albuminuria Glomeruli Interleukin-6 Lipocalin Lipopolysaccharides NIH Acute kidney injury (AKI) contributes to significant morbidity and mortality in the intensive care unit (ICU...

...J. Ibrini; S. Fadel; R.S. Chana; N. Brunskill; B. Wagner; T.S. Johnson; A.M. El Nahas Background: Progressive chronic kidney disease is often associated with albuminuria and renal fibrosis linked to the accumulation of myofibroblasts producing extracellular matrix. Renal myofibroblasts are derived...

...Elisa B.M.I. Peixoto; Alexandros Papadimitriou; Jacqueline M. Lopes de Faria; Jose B. Lopes de Faria Background/Aims: In diabetic hypertensive rats, tempol reduces albuminuria by restoring the redox imbalance. Increased formation of reactive oxygen species leading to activation of poly(ADP-ribose...

...Ahmed H. Abdelhafiz; Shameela Ahmed; Meguid El Nahas Advancing age is associated with albuminuria and vascular changes. This review will explore the putative links between the two. Vascular ageing involves endothelial dysfunction as well as increased arterial diameter, wall thickness and stiffness...

... of this project was to produce a more rapid and advanced model of DN. Methods: Uninephrectomy was applied to OVE and FVB mice at 2 months of age. Albuminuria, GFR, glomerulosclerosis, interstitial fibrosis, gene expression and monocyte infiltration were evaluated as a function of diabetes and uninephrectomy...

...Lu Yang; Suzana Brozovic; Jianxiang Xu; Yunshi Long; Patricia M. Kralik; Sabine Waigel; Wolfgang Zacharias; Shirong Zheng; Paul N. Epstein Aim: To define renal gene expression during the development of severe albuminuria in OVE26 diabetic mice. Methods: Kidney microarray analysis was performed at 2...

... and Conclusion: Adcy1 is expressed in the kidney specifically by podocytes. In the kidney, Adcy1 does not have a critical role in normal physiological functioning as kidney histology and function are normal in Adcy1–/– mice. However, albumin overload resulted in severe albuminuria in Adcy1–/– mice, whereas wild...

... of TF (TF CT–/– mice) were used to study its role in physiological albuminuria and pathological proteinuria following induction of glomerulonephritis (GN). Results: Absence of the cytoplasmic domain of TF was associated with increased albuminuria, podocyte effacement, reduced podocyte numbers...

... and Western blot. Phosphorylated Smad2,3 (p-Smad2,3) was also measured by Western blot. Results: Decorin gene transfection mediated by a recombinant adenovirus has antirenal fibrosis and anti-albuminuria effects in STZ-induced diabetic rats. TGF-β 1 mRNA and protein expression in diabetic kidney were reduced...

... are not fully understood. Recent studies from our and other laboratories found that genes that belong to the Notch pathway are regulated in patients and in animal models of renal disease. Genetic studies performed on mice with conditional expression of active Notch1 protein showed massive albuminuria...

... quantitative trait loci (QTLs), Rf-1 to Rf-5 , influence proteinuria (UPV), albuminuria (UAV) and focal glomerulosclerosis (FGS). Here we present data obtained in congenic rats to directly assess the role of the Rf-1 and Rf-5 QTLs. Methods: Renal damage (UPV, UAV, and FGS) was assessed in ACI, ACI.FHH...

...Kazuyoshi Okada; Koichi Matsumoto; Susumu Takahashi Background: AST-120, an oral adsorbent, inhibits progression of diabetic nephropathy by reducing albuminuria. The purpose of the present study was to explore the mechanism underlying the protective effect of AST-120 against albuminuria. Methods...

... an acute massive albuminuria in mice. This albuminuria is neither dependent on systemic mediators of inflammation nor angiotensin II. In this study, we examined the contribution of two individual antibodies, the enzyme-inhibiting antibody ASD-37 and the non-enzyme-inhibiting antibody ASD-41...

...Henry B.P.M. Dijkman; Miriam E. Gerlofs-Nijland; Jeroen A.W.M. van der Laak; Jack F.M. Wetzels; Patricia J.T.A. Groenen; Karel J.M. Assmann Administration of a specific combination of anti-aminopeptidase A (APA) mAb (ASD-37/41) in mice induces an acute albuminuria which is independent...

... and different stages of albuminuria but normal glomerular filtration rate and in a group of healthy controls. The sieving characteristics of the glomerular filter were determined using a mathematical model of log normal pore size distribution. Patients with albuminuria above 200 μg/min exhibited a significant...