.... Estimates of incidence and prevalence of narcolepsy vary between studies, while the contribution of changing diagnostic criteria to the variation remains unclear. We aimed to explore sources of heterogeneity in estimates of incidence and prevalence, with a particular focus on diagnostic criteria. Methods...

... (95% CI 0.58–0.84) with significant heterogeneity between estimates ( I 2 = 93.41%, p = 0.000) for the random-effects model. In subgroup analysis, the greater decreased risk was found in studies from Asia (RR 0.62 95% CI 0.51–0.76), whereas a moderate reduction was observed in studies from North...

... 1.16-1.75). Also, diabetics, hypertension, cardiac disease, and statin drugs were associated with increased risk of dementia but negative association was observed in the case of body mass index. There was significant statistical and clinical heterogeneity among studies for the main analysis and most...

...Elan D. Louis There is accumulating evidence that the entity referred to as ‘essential tremor' (ET) is not a single disease. It may be a family of diseases better referred to as ‘the ETs'. This review will summarize the following evidence: (1) the presence of etiological heterogeneity; (2...

...Lucie Brosseau; Pierre Philippe; Ginette Méthot; Pierre Duquette; Boulos Haraoui The etiology of multiple sclerosis (MS) remains unknown despite considerable research involving a number of disciplines for many decades. Cluster analysis was used to disentangle the possible heterogeneity of MS, based...