...Olivia Brancatisano; Megan Reyneke; Jan Cameron; Monique F. Kilkenny; Dawn Harris; Natasha A. Lannin; Dominique A. Cadilhac Objectives: There is limited evidence as to whether knowing a participant’s contact preferences improves completion of telephone assessments in clinical trials. We examined (i...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Intracerebral haemorrhage Ambient temperature Haematoma volume NIHSS score Glasgow Coma Scale score Clinical trials INTERACT Global climate change has elicited...

... elderly patients with ischaemic stroke. On the other hand, upper age limits are frequently used in clinical trials, in part due to safety reasons and logistical concerns. In this study, we model how applying upper age limits will lead to a gender disparity in stroke trials, favouring the inclusion of men...

... of Drug Trial Data1 John F. Kurtzke Departments of Neurology and Community Medicine, Georgetown University School of Medicine, and Neurology Service, Veterans Administration Medical Center, Washington, D.C., USA Key Words. Clinical trials Treatment protocols Statistical testing a and p errors...

... of study results. Methods: We reviewed results from ten antiplatelet stroke prevention clinical trials: CAN TIA, DUTCH TIA, SWED ASA, SALT, UK TIA, CATS, TASS, ESPS, ESPS-2, and CAPRIE to tabulate the frequencies for total subject discontinuation, voluntary withdrawal, and loss to follow-up. Results: Forty...

... (VISP) study is a double-masked, randomized, multicenter clinical trial designed to determine if, in addition to best medical/surgical management, high-dose folic acid, vitamin B 6 , and vitamin B 12 supplements will reduce recurrent stroke compared to lower doses of these vitamins. Patients at least 35...

... Paper Neuroepidemiology 2000;19:100 108 Patterns of Outcome Measurement in Parkinson s Disease Clinical Trials Susan L. Mitchella,b Dan W. Harpera Anita Lau b Rishi Bhalla a aDivision of Geriatric Medicine, bClinical Epidemiology Unit, Loeb Health Research Institute, The Ottawa Hospital, University...

... Evaluation Sciences, University of Virginia, Charlottesville, Va., USA Key Words Surrogate outcome W Clinical trials W Stroke W Cerebral infarct volume Abstract Surrogate outcome measures have been of interest in clinical research for a long time because of their potential ability to save time and cost...

... to in the content or advertisements. Multiple sclerosis Clinical trials Cladribine Interferon beta Optic neuritis Invited Review Neuroepidemiology 1999;18:53 63 Perils and Pitfalls in the Interpretation of Clinical Trials: A Reflection on the Recent Experience in Multiple Sclerosis Douglas S. Goodin...

.... Minority recruitment African Americans Clinical trials Neuroepidemiology Guest Editorial Neuroepidemiology 1997; 16:281-284 Gloria J. Bonnera*b Toni P. M ilesc a Center for Stroke Research, Department of Neurological Sciences, Rush Medical College, Chicago, 111., b Department of Public Health, Mental...

... Measurement Clinical trials Neuroepidemiology O riginal Paper Neuroepidemiology 1996;15:330-338 Kenneth Roclcwood3 Paul Stolee3 b Kellee Howard3 Laurie Mattery3 3 Division of Geriatric Medicine, Dalhousie University, Halifax; b Department of Psychiatry, McMaster University, Hamilton, Canada Use of Goal...

...Ralph L. Sacco The number of clinical trials to evaluate new therapies for stroke treatment and prevention is growing rapidly. Although stroke data banks cannot answer treatment efficacy questions, they can have powerful interactions with the design and conduct of clinical trials. Through data...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Patient selection Clinical trials Migraine Methodological Problems in Migraine Trials Neuroepidemiology 6: 164-171...

... in Migraine Trials Neuroepidemiology 6: 228-233 (1987) Drug Trials in Migraine The Clinician s View on End Points M. G. Bousser, J. C. Baron Clinique des Maladies du Système Nerveux, Hôpital de la Salpêtrière, Paris, France Key Words. Migraine Antimigraine drugs Clinical trials Methodology Abstract...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Migraine Clinical trials Crossover study Parallel study Methodological Problems in Migraine Trials Neuroepidemiology 6: 209-213 (1987) Clinical Trials in Migraine...

...Ian Robinson At present many trials appear to be using subjective data, but using these data in an unsystematic and inappropriate way. In this context it is not surprising that subjective measures have a generally low status amongst investigators in clinical trials in MS. A more careful approach...

...Alastair Compston Since there is no treatment of proven value in patients with MS it is necessary still to select those patients for inclusion in clinical trials who have most to gain and can demonstrate rapidly the effectiveness or not of each new treatment. Experience gained in these trials can...

...David Bates The problems of organising clinical trials in MS include the general aspects relating to clinical trials in any discipline but extend also to specific problems arising in the assessment of a relapsing remitting condition. These factors relating to the clinical characteristics...

... and conduct of clinical trials in acute stroke are discussed in relation to the particular problems posed: need for early initiation of treatment; need for, and difficulties of, diagnostic confirmation; matching of treatment groups by prognostic indicators of uncertain significance, and requirements for large...