Background: There is lack of knowledge on the epidemiological characteristics of brain tumors in Middle Eastern countries. The objective of this study was to study the epidemiological features of primary brain tumors in Jordan. Methods: We conducted a prospective cohort study incorporating data from 16 hospitals in Jordan during a 1 year period (May 1, 2011-April 30, 2012). All primary brain tumors diagnosed in Jordan during the study period were identified. The following parameters were retrieved from patients' files: age, gender, histological type, and location. The demographic data of the country was obtained from the National Department of Statistics. Results: A total of 313 primary brain tumors were identified during the study period. The incidence of primary brain tumors in Jordan among the general population was 5.01 per 100,000 person-years (5.38 in females and 4.65 in males). The incidence in pediatric, adult, and elderly patients was 2.09, 7.29, and 14.38 per 100,000 person-years, respectively. The most common histological types were meningioma (26.2%), glioblastoma (18.9%), astrocytoma (14.1%), and pituitary adenoma (9.3%). Conclusions: The incidence of primary brain tumors in the Jordanian population is relatively low, in part due to the young age of the general population.

1.
de Robles P, Fiest KM, Frolkis AD, Pringsheim T, Atta C, St Germaine-Smith C, Day L, Lam D, Jette N: The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis. Neuro Oncol 2015;17:776-783.
2.
World Health Organization: World Cancer Report, 2014, pp Chapter 5.16.
3.
GLOBOCAN 2012: Cancer Incidence and Mortality Worldwide. IARC Cancerbase No. 11, 2013, 2015.
4.
Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il'yasova D, Kruchko C, McCarthy BJ, Rajaraman P, Schwartzbaum JA, Sadetzki S, Schlehofer B, Tihan T, Wiemels JL, Wrensch M, Buffler PA: Brain tumor epidemiology: consensus from the brain tumor epidemiology consortium. Cancer 2008;113(7 suppl):1953-1968.
5.
Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG: Descriptive epidemiology of primary brain and CNS tumors: results from the central brain tumor registry of the United States, 1990-1994. Neuro Oncol 1999;1:14-25.
6.
Andersson U, Wibom C, Cederquist K, Aradottir S, Borg A, Armstrong GN, Shete S, Lau CC, Bainbridge MN, Claus EB, Barnholtz-Sloan J, Lai R, Il'yasova D, Houlston RS, Schildkraut J, Bernstein JL, Olson SH, Jenkins RB, Lachance DH, Wrensch M, Davis FG, Merrell R, Johansen C, Sadetzki S, Bondy ML, Melin BS: Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer. Neuro Oncol 2014;16:1333-1340.
7.
Bailony MR, Hararah MK, Salhab AR, Ghannam I, Abdeen Z, Ghannam J: Cancer registration and healthcare access in West Bank, Palestine: a GIS analysis of childhood cancer, 1998-2007. Int J Cancer 2011;129:1180-1189.
8.
Jones LA, Chilton JA, Hajek RA, Iammarino NK, Laufman L: Between and within: international perspectives on cancer and health disparities. J Clin Oncol 2006;24:2204-2208.
9.
Rastogi T, Hildesheim A, Sinha R: Opportunities for cancer epidemiology in developing countries. Nat Rev Cancer 2004;4:909-917.
10.
Faleh A, Tamimi S, Almaani W, Kamal F, Tarawnih M: Tumores cerebrales. Análisis de 302 casos. Neurocirugia 1995;6:311-314.
11.
Kadri H, Mawla AA, Murad L: Incidence of childhood brain tumors in Syria (1993-2002). Pediatr Neurosurg 2005;41:173-177.
12.
El-Gaidi MA: Descriptive epidemiology of pediatric intracranial neoplasms in Egypt. Pediatr Neurosurg 2011;47:385-395.
13.
Ibrahim AW: C.N.S. tumors in eastern Saudi Arabia. Neurosurg Rev 1992;15:295-302.
14.
Al Sheyyab M, Bateiha A, Kayed SE, Hajjawi B: The incidence of childhood cancer in Jordan: a population-based study. Ann Saudi Med 2003;23:260-263.
15.
Sadetzki S, Zach L, Chetrit A, Nass D, Hoffmann C, Ram Z, Zaaroor M, Umansky F, Rappaport ZH, Cohen A, Wald U, Rothman S, Hadani M: Epidemiology of gliomas in Israel: a nationwide study. Neuroepidemiology 2008;31:264-269.
16.
Jazayeri SB, Rahimi-Movaghar V, Shokraneh F, Saadat S, Ramezani R: Epidemiology of primary cns tumors in Iran: a systematic review. Asian Pac J Cancer Prev 2013;14:3979-3985.
17.
Department of Statistics of Jordan: Estimated population of the kingdom by sex and age group at the end of 2011, 2011.
18.
Ostrom QT, Gittleman H, Liao P, Rouse C, Chen Y, Dowling J, Wolinsky Y, Kruchko C, Barnholtz-Sloan J: CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol 2014;16(suppl 4):iv1-iv63.
19.
Tarawneh M, Nimri O, Arkoob K, Al Zaghal M: Cancer incidence in Jordan; in Registry JC (ed): Ministry of Health Non-Communicable Diseases Directorate, 2009.
20.
Lee CH, Jung KW, Yoo H, Park S, Lee SH: Epidemiology of primary brain and central nervous system tumors in Korea. J Korean Neurosurg Soc 2010;48:145-152.
21.
Bauchet L, Rigau V, Mathieu-Daudé H, Figarella-Branger D, Hugues D, Palusseau L, Bauchet F, Fabbro M, Campello C, Capelle L, Durand A, Trétarre B, Frappaz D, Henin D, Menei P, Honnorat J, Segnarbieux F: French brain tumor data bank: methodology and first results on 10,000 cases. J Neurooncol 2007;84:189-199.
22.
Deltour I, Johansen C, Auvinen A, Feychting M, Klaeboe L, Schüz J: Time trends in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974-2003. J Natl Cancer Inst 2009;101:1721-1724.
23.
Dobes M, Shadbolt B, Khurana VG, Jain S, Smith SF, Smee R, Dexter M, Cook R: A multicenter study of primary brain tumor incidence in Australia (2000-2008). Neuro Oncol 2011;13:783-790.
24.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-2917.
25.
World Bank: Iran: age Structure from 2002 to 2013. Statista, 2015.
26.
World Bank: Age Distribution in the United States from 2003 to 2013. Statista, 2015.
27.
World Bank: South Korea: age Structure between 2003 and 2013. Statista, 2015.
28.
Gousias K, Markou M, Voulgaris S, Goussia A, Voulgari P, Bai M, Polyzoidis K, Kyritsis A, Alamanos Y: Descriptive epidemiology of cerebral gliomas in northwest Greece and study of potential predisposing factors, 2005-2007. Neuroepidemiology 2009;33:89-95.
29.
McLendon RE, Robinson JS Jr, Chambers DB, Grufferman S, Burger PC: The glioblastoma multiforme in Georgia, 1977-1981. Cancer 1985;56:894-897.
30.
Kuratsu J, Takeshima H, Ushio Y: Trends in the incidence of primary intracranial tumors in Kumamoto, Japan. Int J Clin Oncol 2001;6:183-191.
31.
Chakrabarti I, Cockburn M, Cozen W, Wang YP, Preston-Martin S: A population-based description of glioblastoma multiforme in Los Angeles County, 1974-1999. Cancer 2005;104:2798-2806.
32.
Koch HJ, Klinkhammer-Schalke M, Bogdahn U, Hau P: Circannual distribution of glioblastoma and anaplastic astrocytoma diagnoses in men and women. Biol Rhythm Res 2005;36:439-444.
33.
World Bank: Jordan: age structure from 2003 to 2013. Statista, 2015.
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