Objective: This study aimed to investigate whether mortality is higher for individuals suffering from Mild Cognitive Impairment (MCI). Methods: A community sample of 1,045 dementia-free individuals aged 75 years and over was examined using neuropsychological tests over a 4.5-year period. Data were analyzed with the Cox proportional hazards model after having been adjusted for age, gender, and incident dementia. Results: Association between MCI and mortality was examined subject to varied diagnostic criteria of MCI. We found an increased risk of death that was about 1.5 times higher for individuals with MCI when a cognitive performance of more than 1.5 standard deviation below the mean of age- and education-matched controls was required and the criterion of a cognitive complaint was excluded. Males were at about a 40% increased risk of death. Risk also increased with age by about 8% per year. Incident dementia showed a significant influence on mortality only if it became manifest by 1.5 years after the baseline measurement (follow-up 1). Conclusion: MCI is associated with increased mortality when certain diagnostic criteria are applied.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.