...Paolo Cravedi; Giuseppe Remuzzi; Piero Ruggenenti The ideal treatment of patients with primary membranous nephropathy (MN) and persistent nephrotic syndrome (NS) is still a matter of debate. This is a major issue since these patients may progress to end-stage kidney disease (ESKD) in 5-10 years...

...Pierre Ronco; Hanna Debiec Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy (MN), inspired by studies of Heymann nephritis, a faithful experimental model. These studies led to the identification...

...Marios Papasotiriou; Pantelitsa Kalliakmani; Linghong Huang; Miltiadis Gerolymos; Dimitrios S. Goumenos; Timothy S. Johnson Background/Aims: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults. Transglutaminase type 2 (TG2) contributes to renal scarring through...

...) is a major antigen found in patients with idiopathic membranous nephropathy (MN). The relationship of genetic polymorphisms of PLA2R with the susceptibility and clinical outcomes of this disease is unknown. Methods: We studied 199 patients with idiopathic MN followed up for 3.7 ± 3.2 years. We enrolled 33...

... correlated with u-Prot, HbA 1 c and SI. Among biopsy-proven nondiabetic nephropathies, elevation of u-IVc was distinctively observed in membranous nephropathy and anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. Conclusion: u-IVc levels were elevated with the increase in u-Prot, HbA...

...F. Floccari; V. Cosentini; M. Giacobbe; G. Coppolino; S. Campo; D. Bolignano; D. Tripodo; L. Nostro; M. Buemi The treatment of membranous nephropathy is a highly controversial issue. As some patients may have spontaneous remission, in about 50% of cases the risk of treating patients with drugs...

...Detlef Bockenhauer; Hanna Debiec; Neil Sebire; Martin Barratt; Paul Warwicker; Pierre Ronco; Robert Kleta Background: Membranous nephropathy (MN) is the most common histological diagnosis in adults with nephrotic syndrome and a leading cause of end-stage kidney failure from glomerulonephritis...

...Morito Endo; Yoshinobu Fuke; Mariko Tamano; Mutsuko Hidaka; Isao Ohsawa; Takayuki Fujita; Hiroyuki Ohi Background/Aims: The complement system plays an important role in the pathogenesis of membranous nephropathy (MN). In order to elucidate the regulatory mechanism of complement activation, we...

...Keiichi Yoshimoto; Takashi Wada; Kengo Furuichi; Norihiko Sakai; Yasunori Iwata; Hitoshi Yokoyama Background: A considerable diversity of prognosis is seen with idiopathic membranous nephropathy (IMN). The initial factors affecting long-term outcome remain unclear. Methods: We studied...